Patents by Inventor Gerard Ponsinet

Gerard Ponsinet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4999355
    Abstract: Compounds of formula: ##STR1## in which: either R.sub.1 represents 4-phenyl-1,2,3,6-tetrahydro-1-pyridyl or 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-pyridyl, R.sub.2 represents hydrogen, alkoxy of 1 or 2 carbon atoms, hydroxyl, alkyl, alkylthio, alkylcarbonyloxy, phenylalkylcarbonyloxy, phenylalkyl or --NR.sub.4 R.sub.5 in which R.sub.4 represents hydrogen or alkyl and R.sub.5 represents alkyl, phenyl, monohalogenated phenyl or pyridyl, and R.sub.3 represents a hydrogen atom, or else R.sub.2 represent phenyl and R.sub.3 represents hydrogen or hydroxyl;or R.sub.1 represnets 4-phenyl-1-piperazinyl whose phenyl nucleus has a substituent halogen atom or hydroxyl radical in the 4-position, R.sub.2 represents alkoxy and R.sub.3 represents hydrogen;it being understood that when R.sub.1 represents the 4-phenyl-1,2,3,6-tetrahydro-1-pyridyl radical, R.sub.
    Type: Grant
    Filed: March 6, 1989
    Date of Patent: March 12, 1991
    Assignee: Rhone-Poulenc
    Inventors: Marie-Therese Comte, Claude Gueremy, Gerard Ponsinet
  • Patent number: 4971979
    Abstract: Substituted alkadienes of formula: ##STR1## in which R.sub.1 is hydroxy or acetoxy, R.sub.2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, andR.sub.3 is alkylthio or alkoxy and R.sub.4 is naphthoyl or optionally substituted benzoyl,or R.sub.3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R.sub.4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio,or R.sub.3 and R.sub.4 form, with the carbon atom to which they are attached, a ring-system of formula: ##STR2## in which R.sub.5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: November 20, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel
  • Patent number: 4886835
    Abstract: Substituted alkadienes of the formula: ##STR1## in which R.sub.1 is hydroxy or acetoxy, R.sub.2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, andR.sub.3 is alkylthio or alkoxy and R.sub.4 is naphthoyl or optionally substituted benzoyl,or R.sub.3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R.sub.4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio,or R.sub.3 and R.sub.4 form, with the carbon atom to which they are attached, a ring-system of formula: ##STR2## in which R.sub.5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: December 12, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel
  • Patent number: 4831034
    Abstract: Compounds of formula (I) in which the broken line forms a phenyl, naphthyl, pyridyl, indolizine, pyrrolo[1,2-a]pyrazine, pyrrolo[1,2-a]pyrimidine or pyrrolo[1,2-c]pyrimidine ring-system, R=H, halogen, OH, alkyl, alkyloxy or alkylthio, R'=H, halogen, alkyl, alkyloxy, alkylthio, CN or CF.sub.3, n and p=1, 2 or 3, the alkyl radicals having 1 to 4 C in a straight or branched chain.These products are useful as neuroleptics.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: May 16, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Michel Barreau, Marie-Therese Comte, Jean-Luc Malleron, Gerard Ponsinet
  • Patent number: 4826974
    Abstract: Pyrrolo[1,2-a]azepinone derivatives of formula: ##STR1## in which R.sub.3 is H or halogen and either (A) R is benzyl or phenylthio in which the phenyls are optionally substituted by one or more halogens or hydroxy, alkyl, alkyloxy or alkylthio radicals, R.sub.1 and R.sub.2, which may be identical or different, denote alkyl optionally substituted by dialkylamino in which the alkyls are optionally joined to form a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl ring substituted by alkyl, or alternatively R.sub.1 and R.sub.2 form a heterocyclic ring chosen from pyrrolidine, piperidine, morpholine and piperazine, substituted by alkyl, alkenyl (2 to 4 C), benzyl or phenethyl optionally substituted by halogen, alkyl, alkyloxy, alkylthio, CF.sub.
    Type: Grant
    Filed: November 4, 1987
    Date of Patent: May 2, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Michel Barreau, Marie-Therese Comte, Daniel Farge, Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel
  • Patent number: 4769366
    Abstract: Pyrrolo[1,2-a]azepinone derivatives of formula: ##STR1## in which R.sub.3 is H or halogen and either (A) R is benzyl or phenylthio in which the phenyls are optionally substituted by one or more halogens or hydroxy, alkyl, alkyloxy or alkylthio radicals, R.sub.1 and R.sub.2, which may be identical or different, denote alkyl optionally substituted by dialkylamino in which the alkyls are optionally joined to form a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl ring substituted by alkyl, or alternatively R.sub.1 and R.sub.2 form a heterocyclic ring chosen from pyrrolidine, piperidine, morpholine and piperazine, substituted by alkyl, alkenyl (2 to 4 C), benzyl or phenethyl optionally substituted by halogen, alkyl, alkyloxy, alkylthio, CF.sub.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: September 6, 1988
    Assignee: Rhone-Poulenc Sante
    Inventors: Michel Barreau, Marie-Therese Comte, Daniel Farge, Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel
  • Patent number: 4556657
    Abstract: New compounds of the formula: ##STR1## wherein X represents hydrogen, halogen, alkyl (1 to 4 C), alkoxy (1 to 4 C), cyano or nitro, R represents alkyl (1 to 4 C) optionally substituted by hydroxy, or alkenyl (2 to 4 C), and n represents 0 or 1, and one of the symbols m and p represents the figure 0 and the other represents the figure 1.The new compounds are therapeutically useful, more particularly as tranquillizers and anticonvulsants.
    Type: Grant
    Filed: April 21, 1983
    Date of Patent: December 3, 1985
    Assignee: Rhone-Poulenc Sante
    Inventors: Daniel Farge, Andre Leger, Gerard Ponsinet
  • Patent number: 4550110
    Abstract: New compounds of the formula ##STR1## wherein X represents hydrogen, halogen, alkyl (1 to 4 C), alkoxy (1 to 4 C), cyano or nitro, R represents hydrogen, alkyl (1 to 4 C) [unsubstituted or substituted by 1, 2 or 3 halogens, alkenyl (2 to 4 C), alkynyl (2 to 4 C) or alkoxy (1 to 4 C)], phenyl [unsubstituted or substituted by 1, 2 or 3 halogens, alkyl (1 to 4 C), alkoxy (1 to 4 C), nitro or trifluoromethyl] or phenylalkyl (1 to 4 C) or phenylalkynyl (2 to 4 C) in which the phenyl radicals are optionally substituted as indicated above, Z represents an oxygen or sulphur atom, and one of m and p represents the figure O and the other the figure 1.The new compounds are therapeutically useful, more particularly as tranquillizers and anticonvulsants.
    Type: Grant
    Filed: April 21, 1983
    Date of Patent: October 29, 1985
    Assignee: Rhone-Poulenc Sante
    Inventors: Daniel Farge, Andre Leger, Gerard Ponsinet
  • Patent number: 4363909
    Abstract: Isoquinoline derivatives of the formula ##STR1## wherein the symbol A.sub.1 represents an isoquinol-8-yl, 3-methylisoquinol-8-yl, 3-hydroxymethylisoquinol-5-yl, 3-carboxymethylisoquinol-5-yl, quinol-5-yl, thienopyridyl, benzimidazolyl, thienyl or thiazolyl radical, a 4-(or 5-)carboxyalkylthiazol-2-yl radical in which the alkyl moiety is linear or branched and contains 1 to 4 carbon atoms, or a 1,3,4-thiadiazol-2-yl, pyrazolyl, imidazolyl, pyrimidinyl, pyridazinyl or pyrazinyl radical, monocyclic heterocyclic rings within the definition of A.sub.1 being optionally substituted by a linear or branched alkyl radical containing 1 to 4 carbon atoms, in the (S) or (R,S) form or mixtures thereof, and salts thereof possess useful pharmocological properties, in particular antiviral activity.
    Type: Grant
    Filed: December 2, 1980
    Date of Patent: December 14, 1982
    Assignee: Rhone Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4327095
    Abstract: Compounds of the formula: ##STR1## wherein A represents pyrid-2-yl, quinol-2-yl or 1,8-naphthyridin-2-yl, each such radical being optionally substituted by a halogen atom, or an alkyl or alkoxy radical of 1 through 4 carbon atoms, and R represents hydrogen, an alkyl radical of 1 through 4 carbon atoms, an alkenyl radical of 2 through 4 carbon atoms or an alkanoyl radical of 1 through 4 carbon atoms, are new compounds possessing pharmacological properties. They are particularly active as tranquillizers, anti-convulsants, decontracturants and hypnogenic agents.
    Type: Grant
    Filed: March 13, 1980
    Date of Patent: April 27, 1982
    Assignee: Rhone-Poulenc Industries
    Inventors: Daniel Farge, Andre Leger, Gerard Ponsinet
  • Patent number: 4287197
    Abstract: Isoquinoline derivatives of the formula: ##STR1## wherein R.sub.1 represents alkyl of 1 through 8 carbon atoms, and n represents 1 or 2, are new compounds possessing useful pharmacological properties. They are particularly valuable as analgesic, anti-inflammatory, antipyretic or antiviral agents.
    Type: Grant
    Filed: May 6, 1980
    Date of Patent: September 1, 1981
    Assignee: Rhone-Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4271156
    Abstract: Compounds of the general formula: ##STR1## wherein R.sub.1 represents hydrogen or halogen in the 4-, 5- or 6-position of the pyridyl radical and R.sub.2 represents hydrogen, straight- or branched-chain alkyl of 1 to 4 carbon atoms or phenyl, possess anthelmintic activity, having a broad spectrum of activity against nematodes.
    Type: Grant
    Filed: November 14, 1979
    Date of Patent: June 2, 1981
    Assignee: Rhone-Poulenc Industries
    Inventors: Jean-Dominique Bourzat, Daniel Farge, Andre Leger, Gerard Ponsinet
  • Patent number: 4271167
    Abstract: New dithiocarbamates of the formula: ##STR1## in which R.sub.1 is hydrogen or halogen in the 4-, 5- or 6-position, n is equal to 0 or 1, R.sub.2 represents hydrogen or various aliphatic or aromatic radicals which may be substituted, R.sub.3 represents hydrogen or various aliphatic radicals, and R.sub.4 represents a hydrogen atom or an alkyl radical, their optically active forms, and their salts, when such salts exist, are valuable anthelmintic agents. They may be made inter alia by reduction of the corresponding ketones.
    Type: Grant
    Filed: November 14, 1979
    Date of Patent: June 2, 1981
    Assignee: Rhone-Poulenc Industries
    Inventors: Jean-Dominique Bourzat, Daniel Farge, Andre Leger, Gerard Ponsinet
  • Patent number: 4269842
    Abstract: Rhinoviral complaints are treated by administering a product of the general formula: ##STR1## in the (S) form, in which formula A is pyrid-3-yl which is unsubstituted or substituted in the 2-position by chlorine, fluorine or methoxy, isoquinol-5-yl, or 3-methyl-isoquinol-5-yl, or one of its pharmaceutically acceptable salts.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: May 26, 1981
    Assignee: Rhone-Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4261999
    Abstract: Thienopyridine derivatives of the formula: ##STR1## wherein the symbol A represents pyrid-3-yl, isoquinol-5-yl, or a 3-alkylisoquinol-5-yl group in which the alkyl radical is of 1 through 10 carbon atoms, and one of the symbols X and Y represents a single bond and the other represents the vinylene radical, are new compounds possessing useful pharmacological properties. They are particularly useful as anti-viral agents and, in certain cases, as analgesics, anti-inflammatory agents and anti-pyretics.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: April 14, 1981
    Assignee: Rhone-Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4261993
    Abstract: Indole derivatives of the formula: ##STR1## wherein Z represents hydrogen, alkyl of 1 through 10 carbon atoms, or alkoxyalkyl of the formula --(CH.sub.2).sub.n --OR in which R represents alkyl of 1 through 8 carbon atoms and n represents 1 or 2, and their non-toxic pharmaceutically acceptable acid addition salts, are new compunds possessing useful pharmacological properties. They are particularly valuable as analgesic agents; some of them are also useful as anti-inflammatory and antipyretic agents.
    Type: Grant
    Filed: May 6, 1980
    Date of Patent: April 14, 1981
    Assignee: Rhone Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4261992
    Abstract: Isoquinoline derivatives of the formula: ##STR1## wherein R represents alkyl of 1 through 8 carbon atoms, and n represents 1 or 2, and their non-toxic pharmaceutically acceptable acid addition salts, are new compounds possessing useful pharmacological properties. They are particularly valuable as analgesic agents; some of them are also useful as anti-inflammatory and antipyretic agents.
    Type: Grant
    Filed: May 6, 1980
    Date of Patent: April 14, 1981
    Assignee: Rhone Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4225589
    Abstract: Daunorubicin derivatives of the formula: ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## in which (i) X.sub.1 and X.sub.2 both represent oxygen or both represent sulphur and the symbols R.sub.3 each represent alkyl of 1 through 4 carbon atoms, phenyl or phenyl substituted in the para-position by methyl, methoxy or methylthio, or together form an alkylene radical of 2 through 4 carbon atoms, or (ii) one of X.sub.1 and X.sub.2 represents oxygen and the other represents sulphur and the symbols R.sub.3 together form an alkylene radical of 2 through 4 carbon atoms, and R.sub.4 represents hydrogen, alkyl of 1 through 4 carbon atoms or phenyl, and R.sub.2 represents hydrogen or trifluoroacetyl, are new compounds possessing anti-tumour properties.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: September 30, 1980
    Assignee: Rhone-Poulenc Industries
    Inventors: Jean-Bernard Ducep, Daniel Farge, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4189480
    Abstract: Isoquinoline derivatives of the formula: ##STR1## wherein A represents pyrid-3-yl, isoquinol-5-yl or a 3-alkylisoquinol-5-yl radical in which the alkyl moiety contains 1 to 10 carbon atoms, are new compounds, possessing useful pharmacological properties. They are particularly valuable as analgesic, anti-inflammatory and antipyretic agents.
    Type: Grant
    Filed: November 8, 1978
    Date of Patent: February 19, 1980
    Assignee: Rhone-Poulenc Industries
    Inventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
  • Patent number: 4185111
    Abstract: Daunorubicin derivatives of the general formula: ##STR1## wherein each of the symbols R represents a hydrogen atom or a methyl or ethyl radical, are new therapeutically useful compounds possessing anti-tumoral properties.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: January 22, 1980
    Assignee: Rhone-Poulenc Industries
    Inventors: Jean-Bernard Ducep, Daniel Farge, Gerard Ponsinet, Daniel Reisdorf