Patents by Inventor Gerard R. Le Fur
Gerard R. Le Fur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4711890Abstract: Compounds of the formula: ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, phenyl, C.sub.3-6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R.sub.3 and R.sub.4 being H or alkyl, R.sub.5 being alkenyl or alkynyl, and the sum of the carbon atoms in R.sub.3, R.sub.4 and R.sub.5 being 2 to 5, R.sub.2 is as defined for R.sub.1 and may also represent ##STR3## in which n is 0, 1, 2 or 3, it also being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a 5-, 6- or 7-membered heterocyclic radical which can contain another hetero-atom chosen from O and N and which can carry 1 or 2 substituents, Z is phenyl, pyridinyl, thienyl, thiazol-2-yl or substituted phenyl, X and R.sub.0 are H, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro or CF.sub.3, A represents N or CH and E represents N or CH, some of which are known compounds, are therapeutically useful compounds useful in the treatment of anxiety states or of pulmonary, renal, circulatory or cardiovascular disorders.Type: GrantFiled: December 22, 1983Date of Patent: December 8, 1987Assignee: Rhone-Poulenc SanteInventors: Marie-Christine Dubroeucq, Gerard R. Le Fur, Christian L. A. Renault
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Patent number: 4684652Abstract: Compounds of the formula: ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, phenyl, C.sub.3-6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R.sub.3 and R.sub.4 being H or alkyl, R.sub.5 being alkenyl or alkynyl, and the sum of the carbon atoms in R.sub.3, R.sub.4 and R.sub.5 being 2 to 5, R.sub.2 is as defined for R.sub.1 and may also represent ##STR3## in which n is 0, 1, 2 or 3, it also being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a 5-, 6- or 7-membered heterocyclic radical which can contain another hetero-atom chosen from O and N and which can carry 1 or 2 substituents, Z is phenyl, pyridinyl, thienyl, thiazol-2-yl or substituted phenyl, X and R.sub.0 are H, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro or CF.sub.3, A represents N or CH and E represents N or CH, some of which are known compounds, are therapeutically useful compounds useful in the treatment of anxiety states or of pulmonary, renal, circulatory or cardiovascular disorders.Type: GrantFiled: August 8, 1985Date of Patent: August 4, 1987Assignee: Rhone-Poulenc SanteInventors: Marie-Christine Dubroeucq, Gerard R. Le Fur, Christian L. A. Renault
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Patent number: 4535080Abstract: Compounds are disclosed as useful as drugs or as intermediates for the manufacture of drugs, the compounds having the formula: ##STR1## in which X is hydrogen, chlorine, alkyl, alkoxy or alkylthio having 1 to 3 carbon atoms, R.sub.2 is hydrogen or alkyl having 1 to 3 carbon atoms, Y.sub.2 is chlorine and Y.sub.1 is chlorine or ##STR2## in which R.sub.1 is hydrogen, straight or branched chain alkyl having 1 to 7 carbon atoms, cycloalkyl having 3 to 7 carbon atoms or cycloalkylalkyl having 4 to 8 carbon atoms, or Y.sub.2 and Y.sub.1 are both OH. Also disclosed are methods for preparation of the compounds.Type: GrantFiled: August 24, 1983Date of Patent: August 13, 1985Assignee: Pharmuka LaboratoiresInventors: Francois Audiau, Claude G. A. Gueremy, Gerard R. Le Fur
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Patent number: 4505916Abstract: Compounds, useful as medicaments, of the formula: ##STR1## in which R is hydrogen, alkyl, alkenyl or arylalkyl, R.sub.1 is hydrogen, alkyl or alkenyl, R.sub.2 is hydrogen, alkyl, arylalkyl, phenyl, pyridyl, thienyl or substituted phenyl, X is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, nitro, amino or amino substituted by one or two alkyl groups, and A represents a CO or CH.sub.2 group.Type: GrantFiled: September 29, 1982Date of Patent: March 19, 1985Assignee: PharmindustrieInventors: Alain A. Champseix, Gerard R. Le Fur, Christian L. A. Renault
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Patent number: 4493838Abstract: Compounds useful as medicaments, particularly useful as a hypnotic, an anticonvulsant and for the treatment of anxiety states and psychoneurotic states of the formula: ##STR1## in which X is hydrogen, halogen, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms or alkylthio containing 1 to 4 carbon atoms, one of the substituents R.sub.1 and R.sub.2 is hydrogen, alkyl containing 1 to 4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms, alkylthio containing 1 to 4 carbon atoms, trifluoromethyl, nitro, unsubstituted amino or amino substituted by one or two alkyl containing 1 to 2 carbon atoms, and the other of the substituents R.sub.1 and R.sub.2 is a group of the formula: ##STR2## in which n is 1, 2 or 3 and R is hydrogen or alkyl containing 1 to 4 carbon atoms.Type: GrantFiled: September 29, 1982Date of Patent: January 15, 1985Assignee: PharmindustrieInventors: Alain A. Champseix, Gerard R. Le Fur
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Patent number: 4478841Abstract: Compounds of general formula: ##STR1## wherein X represents a hydrogen or halogen atom, R represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and A represents the 1,2,5,6-tetrahydro-4-pyridyl or the 1,2,3,4,5,6-hexahydro-4-pyridyl radical, with the proviso that when A is the 1,2,3,4,5,6-hexahydro-4-pyridyl radical, R is alkyl having 1 to 3 carbon atoms, are disclosed together with methods for their preparation and their use in the treatment of migraines, as antithrombosis agents or as rapid acting thymoanaleptic medicaments.Type: GrantFiled: May 3, 1982Date of Patent: October 23, 1984Assignee: Pharmuka LaboratoiresInventors: Francois Audiau, Gerard R. Le Fur
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Patent number: 4435410Abstract: Compounds of the general formula: ##STR1## in which X represents a hydrogen or halogen atom, for example fluorine or chlorine, and R represents an alkyl group having 1 to 3 carbon atoms or alkenyl group having 2 to 3 carbon atoms are disclosed together with methods for their preparation and their use in the treatment of migraines, as anti-thrombosis agents or as rapid acting thymoanaleptic medicaments.Type: GrantFiled: May 3, 1982Date of Patent: March 6, 1984Assignee: PharmindustrieInventors: Gerard R. Le Fur, Christian L. A. Renault
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Patent number: 4433150Abstract: Compounds, useful as medicaments, of the formula: ##STR1## in which R is hydrogen, alkyl, alkenyl or arylalkyl, R.sub.1 is hydrogen, alkyl or alkenyl, R.sub.2 is hydrogen, alkyl, arylalkyl, phenyl, pyridyl, thienyl or substituted phenyl, X is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, nitro, amino or amino substituted by one or two alkyl groups, and A represents a CO or CH.sub.2 group.Type: GrantFiled: December 2, 1980Date of Patent: February 21, 1984Assignee: PharmindustrieInventors: Alain A. Champseix, Gerard R. Le Fur, Christian L. A. Renault
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Patent number: 4416888Abstract: Compounds of the general formula; ##STR1## wherein R represents an alkyl group having 1 to 3 carbon atoms and X represents a hydrogen or halogen atom are disclosed together with methods for their preparation and their use in the treatment of migraines, as anti-thrombosis agents or as rapid acting thymoanaleptic medicaments.Type: GrantFiled: May 3, 1982Date of Patent: November 22, 1983Assignee: PharmindustrieInventors: Gerard R. Le Fur, Francois Audiau
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Patent number: 4416898Abstract: A method for the treatment of degenerative diseases such as Parkinsonism and aging by the administration of a pharmaceutically effective amount of L-methionine or DL-methionine.Type: GrantFiled: March 1, 1982Date of Patent: November 22, 1983Assignee: Pharmuka LaboratoiresInventor: Gerard R. Le Fur
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Patent number: 4405789Abstract: Compounds useful as medicaments, of the formula: ##STR1## in which X is hydrogen, halogen, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms or alkylthio containing 1 to 4 carbon atoms, one of the substituents R.sub.1 and R.sub.2 is hydrogen, alkyl containing 1 to 4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms, alkylthio containing 1 to 4 carbon atoms, trifluoromethyl, nitro, unsubstituted amino or amino substituted by one or two alkyl containing 1 to 2 carbon atoms, and the other of the substituents R.sub.1 and R.sub.2 is a group of the formula: ##STR2## in which n is 1, 2 or 3 and R is hydrogen or alkyl containing 1 to 4 carbon atoms.Type: GrantFiled: February 24, 1981Date of Patent: September 20, 1983Assignee: PharmindustrieInventors: Alain A. Champseix, Gerard R. Le Fur
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Patent number: 4402961Abstract: Compounds, useful as medicaments, of the formula: ##STR1## in which R is fixed in position 2 or 4 on the cycle of the quinoline and indicates a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, pyridyl, thienyl, phenyl or substituted phenyl group, X is fixed in position 5, 6, 7 or 8 on the cycle of the quinoline and indicates a hydrogen or halogen atom or an alkyl, alkoxy or alkylthio group containing 1 to 4 carbon atoms or CF.sub.3 group, R.sub.1 is a hydrogen atom or an alkyl containing 1 to 4 carbon atoms, alkenyl containing 3 to 4 carbon atoms or arylalkyl group, A is a CO, CHOH, or CH.sub.Type: GrantFiled: June 9, 1981Date of Patent: September 6, 1983Assignee: PharmindustrieInventors: Marie-Christine Dubroeucq, Claude G. A. Gueremy, Gerard R. Le Fur, Jacques Mizoule
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Patent number: 4357337Abstract: Compounds, which can be used as medicaments, of the formula: ##STR1## in which n is 1, 2 ore 3, X is fixed in position 4, 5, 6 or 7 on the cycle ##STR2## and represents a hydrogen atom or a halogen atom or an alkyl, alkoxy or alkylthio group having 1 to 4 carbon atoms, the ##STR3## is fixed in position 2 or 3 on the cycle ##STR4## and the broken line represents a second possible bond, are disclosed for the treatment of states of depression, as analgesics and anti-migraine substances.Type: GrantFiled: June 8, 1981Date of Patent: November 2, 1982Assignee: PharmindustrieInventors: Marie-Christine Dubroeucq, Claude G. A. Gueremy, Christian L. A. Renault, Gerard R. Le Fur
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Patent number: 4299835Abstract: Pharmaceutical preparations containing as active ingredient a compound having the formula: ##STR1## wherein R represents hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; andX represents hydrogen, alkyl, alkoxy or alkylthio, the alkyl groups of each containing 1 to 4 carbon atoms, halogen (chlorine, fluorine, bromine or iodine), trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups or by acyl or alkylsulphonyl, the alkyl groups of each containing 1 to 4 carbon atoms, which are particularly advantageous for the treatment of pathological states caused by a disturbance in the functioning of the serotoninergical systems in mammals. These preparations may also be used as anxiolytics.Type: GrantFiled: November 24, 1980Date of Patent: November 10, 1981Assignee: PharmindustrieInventors: Alain A. Champseix, Claude G. A. Gueremy, Gerard R. Le Fur
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Patent number: 4294841Abstract: A drug useful as antiarhythmic, antidepressant and anxiolytic containing as an active agent a compound of the formula ##STR1## wherein X and Y are the same or different and represent hydrogen or halogen atoms, or 1-4C alkyl groups, 1-4C alkoxy groups, 1-4C alkylthio groups, CF.sub.3, OH, NH.sub.2, 1-4C monoalkylamino or amino groups substituted by a 1-4C alkylsulfonyl group, a 1-5C alkylcarbonyl group or an aroyl group and A is a CO, CHOH or CH.sub.2 group, or a salt of said compound with a pharmaceutically acceptable acid, is disclosed together with methods for the preparation thereof and its use in human therapy.Type: GrantFiled: November 27, 1979Date of Patent: October 13, 1981Assignee: PharmindustrieInventors: Alain A. Champseix, Gerard R. Le Fur
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Patent number: 4237139Abstract: Pharmaceutical preparations containing as active ingredient a compound having the formula: ##STR1## wherein R represents hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; andX represents hydrogen, alkyl, alkoxy or alkylthio, the alkyl groups of each containing 1 to 4 carbon atoms, halogen (chlorine, fluorine, bromine or iodine), trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups or by acyl or alkylsulphonyl, the alkyl groups of each containing 1 to 4 carbon atoms, which are particularly advantageous for the treatment of pathological states caused by a disturbance in the functioning of the serotoninergical systems in mammals. These preparations may also be used as anxiolytics.Type: GrantFiled: December 12, 1978Date of Patent: December 2, 1980Assignee: PharmindustrieInventors: Alain A. Champseix, Claude G. A. Gueremy, Gerard R. Le Fur