Patents by Inventor Gerardo Burton

Gerardo Burton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds having antibacterial activity, process for their preparation and pharmaceutical compositions comprising them
    Patent number: 9255071
    Abstract: A pharmaceutically acceptable salt, prodrug or derivative compound of the formula I, wherein R1 is selected from H, a (C1-C5) alkyl group and a COR4 group; R2 is selected from H, a (C1-C5) alkyl group and a COR5 group; R3 is selected from H, a (C1-C5) alkyl group, a (C1-C5)-O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an aryl group, and an aryl (C1-C5) alkyl group wherein the aryl group can be an unsubstituted aryl or substituted with one or more R6 groups and an NHCOR5 group, or the R2 and R3 groups together with N may form a piperidine, morpholine or piperazine group; R4 is selected from H and a (C1-C5)alkyl group; R5 is selected from an aryl group unsubstituted or substituted with one or more R6, linear or branched(C1-C5) alkyl or pyridyne groups and a pyridine group; R6 is selected from (C1-C5)alkyl groups, halogen and nitro.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 9, 2016
    Assignees: Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Laboratorios Richmond Sociedad Anónima Comercial Industrial y Financiera
    Inventors: Gerardo Burton, Fernando Javier Duran, Mario David Martinez, Elvira Zini, Veronica Mora Munoz, Lucila Bertoncello
  • COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
    Publication number: 20140357678
    Abstract: A pharmaceutically acceptable salt, prodrug or derivative compound of the formula I, wherein R1 is selected from H, a (C1-C5) alkyl group and a COR4 group; R2 is selected from H, a (C1-C5) alkyl group and a COR5 group; R3 is selected from H, a (C1-C5) alkyl group, a (C1-C5)-O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an aryl group, and an aryl (C1-C5) alkyl group wherein the aryl group can be an unsubstituted aryl or substituted with one or more R6 groups and an NHCOR5 group, or the R2 and R3 groups together with N may form a piperidine, morpholine or piperazine group; R4 is selected from H and a (C1-C5)alkyl group; R5 is selected from an aryl group unsubstituted or substituted with one or more R6, linear or branched(C1-C5) alkyl or pyridyne groups and a pyridine group; R6 is selected from (C1-C5)alkyl groups, halogen and nitro.
    Type: Application
    Filed: January 10, 2013
    Publication date: December 4, 2014
    Inventors: Gerardo Burton, Javier Duran, David Martinez, Elvira Zini, Veronica Mora Munoz, Lucila Bertoncello
  • METHOD FOR THE PREPARATION OF 21-HYDROXY-6,19-OXIDOPROGESTERONE (21OH-6OP)
    Publication number: 20090216008
    Abstract: A method of preparing 21-hydroxy-6,19-oxidoprogesterone, or an acylated or phosphorlated version thereof.
    Type: Application
    Filed: February 9, 2009
    Publication date: August 27, 2009
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gerardo BURTON, Carlos P. Lantos, Adriana Silvia Veleiro
  • Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
    Patent number: 7479486
    Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: January 20, 2009
    Assignee: Laboratoires Serono SA
    Inventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
  • METHOD FOR THE PREPARATION OF 21-HYDROXY-6,19-OXIDOPROGESTERONE (21OH-6OP)
    Publication number: 20070249826
    Abstract: A 21-Hydroxy-6,19-oxidoprogesterone derivative of Formula (1): where R is —C(O)—CH2CH3, —C(O)—(CH2)2—COOH, —C(O)—(CH2)7—CH?CH—(CH2)7—COOH, or —C(O)—PO3Na2.
    Type: Application
    Filed: April 12, 2007
    Publication date: October 25, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gerardo Burton, Carlos Lantos, Adriana Veleiro
  • Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21 oh-6op)
    Patent number: 7071328
    Abstract: The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate derivatives. 21OH-6OP and its ester derivatives are antiglucocorticoids for the treatment or prophyl axis of diseases associated to an excess of glucocorticoids, in particular for treating Cushing's syndrome, iatrogenic hypercortisolism or depression.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 4, 2006
    Assignee: Applied Research System ARS Holding N.V.
    Inventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
  • Sulfur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
    Patent number: 7053228
    Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: May 30, 2006
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
  • Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP)
    Publication number: 20050277769
    Abstract: A 21-Hydroxy-6,19-oxidoprogesterone derivative of Formula (1): where R is —C(O)—CH2CH3, —C(O)—(CH2)2—COOH, —C(O)—(CH2)7—CH?CH—(CH2)7—COOH, or —C(O)—PO3Na2.
    Type: Application
    Filed: June 1, 2005
    Publication date: December 15, 2005
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gerardo Burton, Carlos Lantos, Adriana Veleiro
  • Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
    Publication number: 20050222104
    Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
    Type: Application
    Filed: May 6, 2005
    Publication date: October 6, 2005
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gerardo Burton, Carlos Lantos, Adriana Veleiro
  • Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
    Publication number: 20040092733
    Abstract: The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate derivatives. 21OH-6OP and its ester derivatives are antiglucocorticoids for the treatment or prophylaxis of diseases associated to an excess of glucocorticoids, in particular for treating Cushing's syndrome, iatrogenic hypercortisolism or depression.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 13, 2004
    Inventors: Gerardo Burton, Carlos P Lantos, Adriana Silvia Veleiro
  • Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op) for treating excess of glucocorticoids
    Publication number: 20040029846
    Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of diseases associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues having the formula FORMULAwherein X is S, SO and SO2, and R is either M or OH, for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
    Type: Application
    Filed: August 20, 2003
    Publication date: February 12, 2004
    Inventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
  • 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) and its use as medicament for treating excess of glucocorticoids
    Patent number: 6303591
    Abstract: The comformationally highly bent steroid 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) has been found to be a selective antiglucocoriticoid virtually lacking mineralococorticoid or glucocorticoid properties as well as affinity for MR or PR and is used for the treating of diseases associated with an excess of glucocordcoids in the body, such as the Cushing's syndrome or depression.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: October 16, 2001
    Assignee: Applied Research Systems ARS Holding NV
    Inventors: Gerardo Burton, Carlos Pedro Lantos