Patents by Inventor Gerardo Gutiérrez Fuentes
Gerardo Gutiérrez Fuentes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9296780Abstract: A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17?-ethynyl-17?-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.Type: GrantFiled: December 19, 2012Date of Patent: March 29, 2016Assignees: Crystal Pharma, S.A.U., Population Council Inc.Inventors: Luis Gerardo Gutiérrez Fuentes, Celso Miguel Sandoval Rodriguez
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Patent number: 9000195Abstract: Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, arylalkyl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, arylalkyl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.Type: GrantFiled: July 14, 2009Date of Patent: April 7, 2015Assignee: Crystal Pharma, S.A.U.Inventors: Luis Octavio Silva Guisasola, Lydia Mateos Burón, Antonio Lorente Bonde-Larsen, Luis Gerardo Gutiérrez Fuentes
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Publication number: 20150005518Abstract: A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17?-ethynyl-17?-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.Type: ApplicationFiled: December 19, 2012Publication date: January 1, 2015Applicants: CRYSTAL PHARMA, S.A.U., THE POPULATION COUNCIL INC.Inventors: Luis Gerardo Gutiérrez Fuentes, Celso Miguel Sandoval Rodríguez
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Patent number: 8765785Abstract: The invention concerns fumarate salts of solifenacin, as well as pharmaceutical compositions comprising fumarate salts of solifenacin. The invention furthermore concerns a process for preparing solifenacin and salts thereof. The fumarate salt provides improved properties over the known solifenacin salts, especially in terms of its stability. The novel process for its preparation is furthermore improved over known processes for preparing solifenacin in that it provides a higher yield and recovers a greater amount of starting material.Type: GrantFiled: July 5, 2011Date of Patent: July 1, 2014Assignee: Crystal Pharma, S.A.U.Inventors: Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen, Jaime del Campo López-Bachiller, Celso Sandoval Rodríguez, Yolanda Fernández Sainz
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Patent number: 8722920Abstract: The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group in compounds of general formula (V), wherein R1 is C1-C8 alkyl; and R3 and R4, independently of one another, represent H or C1-C8 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound. The invention also relates to the compounds of formula (V), as well as their enantiomers, solvates and salts.Type: GrantFiled: July 26, 2010Date of Patent: May 13, 2014Assignee: Crystal Pharma S.A.U.Inventors: Antonio Lorente Bonde-Larsen, Pablo Martín Pascual, Mario Laderas Muñoz, Luis Gerardo Gutiérrez Fuentes
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Patent number: 8524693Abstract: The invention relates to processes for obtaining steroids with a spirolactone group in position 17, particularly to industrially obtaining 6?,7?; 15?,16?-dimethylene-3-oxo-17?-pregn-4-ene-21,17-carbolactone, commonly known as Drospirenone, as well as to intermediates useful in said process.Type: GrantFiled: June 16, 2010Date of Patent: September 3, 2013Assignee: Crystal Pharma, S.A.Inventors: Jesús Miguel Iglesias Retuerto, Luis Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen
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Publication number: 20130203804Abstract: The invention concerns fumarate salts of solifenacin, as well as pharmaceutical compositions comprising fumarate salts of solifenacin. The invention furthermore concerns a process for preparing solifenacin and salts thereof. The fumarate salt provides improved properties over the known solifenacin salts, especially in terms of its stability. The novel process for its preparation is furthermore improved over known processes for preparing solifenacin in that it provides a higher yield and recovers a greater amount of starting material.Type: ApplicationFiled: July 5, 2011Publication date: August 8, 2013Applicant: CRYSTAL PHARMA, S.A.U.Inventors: Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen, Jaime del Campo López-Bachiller, Celso Sandoval Rodríguez, Yolanda Fernández Sainz
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Publication number: 20120220797Abstract: The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group in compounds of general formula (V), wherein R1 is C1-C8 alkyl; and R3 and R4, independently of one another, represent H or C1-C8 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound. The invention also relates to the compounds of formula (V), as well as their enantiomers, solvates and salts.Type: ApplicationFiled: July 26, 2010Publication date: August 30, 2012Inventors: Antonio Lorente Bonde-Larsen, Pablo Martín Pascual, Mario Laderas Muñoz, Luis Gerardo Gutiérrez Fuentes
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Publication number: 20120004426Abstract: Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, arylalkyl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, arylalkyl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.Type: ApplicationFiled: July 14, 2009Publication date: January 5, 2012Applicant: RAGACTIVES, S.L.U.Inventors: Luis Octavio Silva Guisasola, Lydia Mateos Burón, Antonio Lorente Bonde-Larsen, Luis Gerardo Gutiérrez Fuentes
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Publication number: 20110144363Abstract: The invention relates to processes for obtaining steroids with a spirolactone group in position 17, particularly to industrially obtaining 6?,7?; 15?,16?-dimethylene-3-oxo-17?-pregn-4-ene-21,17-carbolactone, commonly known as Drospirenone, as well as to intermediates useful in said process.Type: ApplicationFiled: June 16, 2010Publication date: June 16, 2011Applicant: CRYSTAL PHARMA, S.A.Inventors: Jesús Miguel Iglesias Retuerto, Luis Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen
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Publication number: 20110118488Abstract: 6-alkylidenandrost-1,4-dien-3-ones of general formula (I), wherein R is H o alkyl; R1 y R2, independently of one another, represent H, OR3, OC(?O)R4 or O-(GPH), wherein R3 is H; C1-C6 alkyl or aryl; R4 is H or C1-C6 alkyl, and GPH is a hydroxyl protecting group; or R1 and R2, together with the carbon atom to which they are bonded, form a carbonyl group or equivalent or a cyclic ketal; can be obtained by a process comprising subjecting the corresponding 6-alkyliden-4-androsten-3-one to a dehydrogenation reaction in the 1,2 position in the presence of a quinone, a silylating agent and a strong acid.Type: ApplicationFiled: December 12, 2008Publication date: May 19, 2011Applicant: CRYSTAL PHARMA, S.A.Inventors: Francisco Bermejo González, José Andrés Marcos Escribano, Luis Gerardo Gutiérrez Fuentes, Jesús Miguel Iglesias Retuerto, Antonio Lorente Bonde-Larsen