Abstract: A composition for treating sickle cell disease includes a cGMP exosome having a size range between 60 nm to 120 nm, which may be extracted from a human mesenchymal stem cell (hMSC) or human PBMC at 320,000 g, wherein the cGMP exosome may be loaded with a Hemoglobin Subunit Beta (HBB) DNA plasmid carrying a gene encoding a normal beta chain of hemoglobin and alone or in combination with a short interference RNA (siRNA) that silences the translation of the SNP rs334 (A) mutation of the beta chain of a Hemoglobin A protein.

Abstract: Described is a technique for optimization an image for facial detection. More specifically, described is a process of predicting the location of a face within an image and adjusting image settings based on at least a portion of the predicted location of the face. An image may be adjusted based on the characteristics of a metering region, which may be selected prior to performing facial detection. For example, the metering region may be a specified shape with dimensions equal to a certain percentage of the input image and placed at a specified location. The result of using such a metering region is that the image adjustments may be based on a portion of the face, and therefore, may be optimized for facial detection.

Abstract: A method for directing ultrasound energy toward an organ of a subject, including: determining a location of the organ within the subject's body; and directing ultrasound energy at the location of the organ within the subject's body using a wearable ultrasound device.

Abstract: Described is a technique for optimization an image for facial detection. More specifically, described is a process of predicting the location of a face within an image and adjusting image settings based on at least a portion of the predicted location of the face. An image may be adjusted based on the characteristics of a metering region, which may be selected prior to performing facial detection. For example, the metering region may be a specified shape with dimensions equal to a certain percentage of the input image and placed at a specified location. The result of using such a metering region is that the image adjustments may be based on a portion of the face, and therefore, may be optimized for facial detection.

Abstract: Described is a technique for optimization an image for facial detection. More specifically, described is a process of predicting the location of a face within an image and adjusting image settings based on at least a portion of the predicted location of the face. An image may be adjusted based on the characteristics of a metering region, which may be selected prior to performing facial detection. For example, the metering region may be a specified shape with dimensions equal to a certain percentage of the input image and placed at a specified location. The result of using such a metering region is that the image adjustments may be based on a portion of the face, and therefore, may be optimized for facial detection.

Abstract: A gas-powered oven includes a cooking surface and a heat deflecting frame, such that the cooking surface and heat deflecting frame collectively define at least a portion of a cooking chamber. An outer housing extends around the cooking surface and the heat deflecting frame, with the outer housing having an opening formed therein and in communication with the cooking chamber. A first burner is connectable to a gas source and is located within the outer housing and spaced from the cooking chamber. The first burner is elongate and includes a first array of openings formed therein. A second burner is connectable to the gas source and extends into the cooking chamber toward a portion of the heat deflecting frame. The second burner includes a tapered passageway and an expanding passageway downstream of the tapered passageway to achieve desired flow characteristics of the gas flowing through the second burner.

Abstract: A vehicle mirror control system includes a touchpad including a sensing surface operative to produce signals indicative of a desired movement of a vehicle mirror responsive to a gesture detected by the sensing surface. A vehicle mirror assembly and a method are also disclosed.

Abstract: A cap for sealing a mouth of a crown finish or threaded crown finish glass bottle, the crown cap is formed by a circular wall, a curved wall perimetrical to the circular wall, and a closure skirt that descends radially downward and outward from the curved wall and formed by a plurality of interleaved protrusions and depressions, the curved wall has a radius of curvature from 1.5 mm (0.590551 in) to 1.9 mm (0.748031 in) and an arc less than 86°; the crown cap is formed from a circular sheet cutout with a diameter from 33.4949 mm (1.3187 in) to 35.5346 mm (1.399 in), resulting in a crown cap with an axial height less than the axial height of a crown cap from the state of the art.

Abstract: Described is a technique for optimization an image for facial detection. More specifically, described is a process of predicting the location of a face within an image and adjusting image settings based on at least a portion of the predicted location of the face. An image may be adjusted based on the characteristics of a metering region, which may be selected prior to performing facial detection. For example, the metering region may be a specified shape with dimensions equal to a certain percentage of the input image and placed at a specified location. The result of using such a metering region is that the image adjustments may be based on a portion of the face, and therefore, may be optimized for facial detection.

Abstract: A composition for delivering cargo to cytoplasm of a cell, wherein the cargo treats oncological disorders. In one embodiment the composition comprises: an exosome; and cargo, located within the exosome, comprising at least one plasmid. In another embodiment the composition comprises: an exosome; and cargo, located within the exosome, comprising a at least one plasmid. Wherein the cargo transduces autologous T cells into Chimeric Antigen Receptor T cells (CAR-T cells), which comprise at least one antigenic target.

Abstract: An apparatus (200) for detecting light, comprising a detector (100) and a readout circuit (150). The detector (100) comprises: a substrate (10), a phase change material layer (16) supported by the substrate (10), a first electrode (14) in electrical contact with the phase change material layer (16), and a second electrode (18) in electrical contact with the phase change material layer (16). The first and second electrode (14, 18) are operable to bias the phase change material (16) by passing a current through the phase change material as a result of a bias voltage between the first and second electrode (14, 18).

Abstract: Disclosed is a metallic cover cap for sealing a metallic bottle, comprising a gasket provided with a flat central zone and an annular zone which includes an outer rim and an inner rim that are separated by a notch, such that the outer rim extends axially, continues circumferentially, and includes: a first surface; a second surface with a flat portion and a concave portion radially opposite the notch; and a third flat surface that extends between the first and second surfaces, and the inner rim extends axially, continues circumferentially and spaced radially inwards of the first rim, and includes: a first flat surface opposite and perpendicular to the flat zone; a second concave surface radially opposite the notch; and a third flat surface between the first and second surfaces that is inclined toward the notch.

Abstract: A composition for delivering a cargo to the cytoplasm of a cell, wherein the cargo treats Non-Alcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus Type 1 and Type 2, Atherosclerotic Cardiovascular Disease, and Alpha 1 Antitrypsin Deficiency. In another embodiment, the composition comprises: an exosome; cargo located inside the exosome, wherein the cargo comprises short interference RNA (siRNA) that depletes sodium-glucose linked transporter active sites. In another embodiment, the composition comprises: an exosome; cargo location inside the exosome, wherein the cargo corrects the missense SERPINA1 mutation from ‘Z’ to ‘M’.

Abstract: Systems and methods are disclosed herein relating to a momentary contact switch that can be both manually and electronically actuated. In some embodiments, an electronic module can be added to a manual momentary contact switch to enable electronic control. The momentary contact switch can be transitioned between first, second, and third electrical states based on the rotation of a shaft between first, second, and third rotational positions. Rotary arms are selectively engaged by pull arms connected to a master solenoid to selectively rotate the shaft from the first rotational position to the second and third rotational positions.

Abstract: A composition for delivering cargo to cytoplasm of a cell, wherein the cargo treats sickle cell disease. In one embodiment, the composition comprises; an exosome; and cargo, located within the exosome, wherein the cargo comprises short interference RNA (siRNA) with altered single-nucleotide polymorphism SNP rs334 (A) for expressing normal hemoglobin. In another embodiment, the composition comprises: an exosome; and cargo, located within the exosome, wherein the cargo comprises a viral vector containing at least one sequence encoding normal hemoglobin comprising altered SNP rs334.

Abstract: A composition for delivering cargo to cytoplasm of a cell, wherein the cargo manipulates angiogenesis. In one embodiment the composition comprises: an exosome; and cargo, located within the exosome, comprising at least one plasmid. In another embodiment the composition comprises: an exosome; and cargo, located within the exosome, comprising a DNA plasmid bioengineered specifically to self-produce monoclonal neutralizing antibodies.

Abstract: Described is a technique for optimization an image for facial detection. More specifically, described is a process of predicting the location of a face within an image and adjusting image settings based on at least a portion of the predicted location of the face. An image may be adjusted based on the characteristics of a metering region, which may be selected prior to performing facial detection. For example, the metering region may be a specified shape with dimensions equal to a certain percentage of the input image and placed at a specified location. The result of using such a metering region is that the image adjustments may be based on a portion of the face, and therefore, may be optimized for facial detection.

Abstract: Systems and methods are disclosed herein relating to a momentary contact switch that can be both manually and electronically actuated. In some embodiments, an electronic module can be added to a manual momentary contact switch to enable electronic control. The momentary contact switch can be transitioned between first, second, and third electrical states based on the rotation of a shaft between first, second, and third rotational positions. Rotary arms are selectively engaged by pull arms connected to a master solenoid to selectively rotate the shaft from the first rotational position to the second and third rotational positions.

Abstract: A vehicle mirror control system includes a touchpad including a sensing surface operative to produce signals indicative of a desired movement of a vehicle mirror responsive to a gesture detected by the sensing surface. A vehicle mirror assembly and a method are also disclosed.

Abstract: Described is a technique for optimization an image for facial detection. More specifically, described is a process of predicting the location of a face within an image and adjusting image settings based on at least a portion of the predicted location of the face. An image may be adjusted based on the characteristics of a metering region, which may be selected prior to performing facial detection. For example, the metering region may be a specified shape with dimensions equal to a certain percentage of the input image and placed at a specified location. The result of using such a metering region is that the image adjustments may be based on a portion of the face, and therefore, may be optimized for facial detection.