Patents by Inventor Gerardus Smit

Gerardus Smit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10046038
    Abstract: The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific type of fatty acid: a polyunsaturated C18 fatty acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: August 14, 2018
    Assignee: Intervet Inc.
    Inventors: Christian Theodoor Gerardus Smits, Edwin Kets, Henriette Adriaanse
  • Patent number: 10031132
    Abstract: The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (B) to allow for an incubation of the sample with reagents. A reference measurement may be made during this incubation period (TI), preferably at the end thereof. After incubation, the magnetic particles (1) are allowed to contact the sensing surface (111) where a target measurement can be conducted.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: July 24, 2018
    Assignee: Minicare B.V.
    Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
  • Publication number: 20170023470
    Abstract: The present invention relates to a method for evaluating the start of an assay in a fluidic chamber, wherein said start of the assay is based on the dissolving of a reagent in a region of interest in said fluidic chamber. The method may be based on the detection of an optical effect in the region of interest caused by the dissolving of the reagent, comprising the steps: obtaining an optical signal from one or more sub-sections of said region of interest; processing said optical signal to a Boolean signal; and defining the start of the assay based on said Boolean signal. The present invention also relates to a method for evaluating the start of an assay comprising an electrical detection of a change in the conductivity or permittivity of fluid due to the dissolving of reagent as mentioned above.
    Type: Application
    Filed: February 12, 2015
    Publication date: January 26, 2017
    Inventors: PATRICK BRONNEBERG, ROLAND ANTONIUS JOHANNES GERARDUS SMITS, SYTSKE FOPPEN, FRANCISCUS HENDRIKUS VAN HEESCH, HONG LIU, ALBERT HENDRIK JAN IMMINK
  • Publication number: 20150306199
    Abstract: The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific type of fatty acid: a polyunsaturated C18 fatty acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.
    Type: Application
    Filed: December 20, 2013
    Publication date: October 29, 2015
    Applicant: Intervet Inc.
    Inventors: Christian Theodoor Gerardus Smits, Edwin Kets, Henriette Adriaanse
  • Publication number: 20140329335
    Abstract: The invention relates to a method and a device for the detection of magnetic particles (1) in a sample chamber (112). After introduction of the sample into said sample chamber (112), the magnetic particles (1) are first retained within the sample chamber (112) and kept away from the sensing surface (111) by an appropriate magnetic field (B) to allow for an incubation of the sample with reagents. A reference measurement may be made during this incubation period (TI), preferably at the end thereof. After incubation, the magnetic particles (1) are allowed to contact the sensing surface (111) where a target measurement can be conducted.
    Type: Application
    Filed: October 5, 2012
    Publication date: November 6, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
  • Publication number: 20140323856
    Abstract: A system for providing sensory feedback includes a garment (106) that is configured to flexibly and snuggly fit over a portion of a subject. The garment includes one or more sensors (104) disposed therein to monitor activity of the subject or monitor points of interest of the subject. An interpretation module (115) is coupled with the sensors to receive sensor signals and interpret the sensor signals to determine if conditions are met to provide feedback signals to the garment. A feedback modality (108) is incorporated into the garment and is responsive to the feedback signals such that the feedback modality emits energy from the garment to provide sensory information to assist a physician during a procedure.
    Type: Application
    Filed: October 19, 2012
    Publication date: October 30, 2014
    Inventors: Sytske Foppen, Bernardus Jozef Maria Beerling, Willemina Maria Huijnen-Keur, Hendrik Jan De Graaf, Danielle Walthera Maria Kemper-Van De Wiel, Roland Antonius Johannes Gerardus Smits, Albert Hendrik Jan Immink, Femke Karina De Theije, Wendela Meertens
  • Publication number: 20140178433
    Abstract: The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific fatty acid: linoleic acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 26, 2014
    Inventors: Edwin Kets, Christian Theodoor Gerardus Smits, Henriette Adriaanse
  • Patent number: 8586331
    Abstract: The present invention pertains to a method to produce RTX-toxin Apxl by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, to which medium a calcium salt is added to form calcium ions in the medium, wherein the culturing medium contains borogluconate to form a calcium borogluconate complex in the medium.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: November 19, 2013
    Assignee: Intervet International B.V.
    Inventors: Simen-Jan Slagman, Christian Theodoor Gerardus Smits, Bayram Bulut
  • Patent number: 8445235
    Abstract: The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, characterized in that air is passed through the medium, wherein the air has a carbon dioxide content above normal atmospheric level to increase RTX-toxin production during the production phase of the RTX-toxins.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: May 21, 2013
    Assignee: Intervet International B.V.
    Inventors: Simen-Jan Slagman, Christian Theodoor Gerardus Smits
  • Publication number: 20110229934
    Abstract: The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, characterised in that air is passed through the medium, wherein the air has a carbon dioxide content above normal atmospheric level to increase RTX-toxin production during the production phase of the RTX-toxins.
    Type: Application
    Filed: November 25, 2009
    Publication date: September 22, 2011
    Inventors: Simen-Jan Slagman, Christian Theodoor Gerardus Smits
  • Publication number: 20070249788
    Abstract: Energy absorbing material comprising polyolefin particles having as a continuous phase a copolymer of ethylene or propylene and one or more ?-olefin monomers, the copolymer having a density of at most 910 kg/ms and the particles having been formed by cutting at a temperature above the glass transition temperature of the polyolefin, and use of the energy absorbing material as infill material in synthetic grass structures.
    Type: Application
    Filed: July 20, 2005
    Publication date: October 25, 2007
    Inventors: Francois Buijsch Op Den, Wilhelmus Bruls, Leonardus Welzen, Gerardus Smit, Frederik Gaag Van Der, Marinus Olde Weghuis
  • Publication number: 20040170722
    Abstract: The present invention relates to a clear dairy drink, comprising a milk product as the main ingredient and having an extinction in the range of 400 to 800 nm, in particular at 654 nm of less than 1 and to a method for making such drink. The method for producing the drink comprises provision of a milk product of acid pH, which optionally further comprises a negatively charged polysaccharide; optionally subjecting the milk product or the mixture to a temperature treatment and/or homogenisation, and adjusting the pH of the milk product or the mixture to about neutral.
    Type: Application
    Filed: December 29, 2003
    Publication date: September 2, 2004
    Inventors: William Kloek, Antonius Maria Gerardus Smits, Antien Frances Zuidberg