Abstract: A photodynamic therapy (PDT) system includes an elongated interventional device with a bundle of optical fibers forming respective light exit ports which can be individually accessed. The bundle has an optical shape sensing fiber arranged for sensing position and orientation of the light exit ports. A processor is configured to generate a light dose signal to allow generation of light outputs to the optical fibers. The light dose signal is generated in response to the determined position and orientation of the light exit ports, and three-dimensional body anatomy image information obtained by a first image modality. The processor is also configured to take image information regarding distribution of a photo sensitizer in the body tissue as input, as well as take into account image information regarding a concentration of oxygen in the body tissue.

Abstract: A Photodynamic Therapy (PDT) system with an elongated interventional device (IDV) with a bundle of optical fibers (F1, F2, F3) forming respective light exit ports which can be individually accessed. The bundle has an optical shape sensing fiber (OSS), e.g. including Fiber Bragg Gratings, arranged for sensing position and orientation (P_O) of the light exit ports. A processor executes a control algorithm which generate a light dose signal (LDS) to allow generation of light outputs (LD1, LD2, LD3) to the plurality of optical fibers (F1, F2, F3) accordingly. The control algorithm generates the light dose signal (LDS) in response to the determined position and orientation of the light exit ports (P_O), and three-dimensional body anatomy image information obtained by a first image modality (I1), e.g. X-ray, MRI, CT, ultrasound, or PET-CT. This combination allows precise application of a light dose distribution for PDT treatment of a tumor with a minimal destruction of connective tissue.

Abstract: Methods and systems are described suitable to determine the effects of sample matrix on the detection of a label so as to allow correction for these sample matrix effects when using the label in an analytical detection technique. The method is particularly advantageous for use in a disposable molecular diagnosis cartridge.