Patents by Inventor Gerben A. Koning

Gerben A. Koning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INCREASING THE BIOAVAILABILITY AND/OR CELLULAR UPDATE OF DRUGS
    Publication number: 20110150984
    Abstract: This invention pertains to methods of increasing the bioavailability and/or cellular uptake of an amphiphilic drug when administered parenterally, which method comprises the step of parenterally co-administering the drug with a short-chain sphingolipid as described herein.
    Type: Application
    Filed: March 2, 2011
    Publication date: June 23, 2011
    Inventors: Robert J. VELDMAN, Wim J. VAN BLITTERSWIJK, Marcel VERHEIJ, Gerben A. KONING
  • Pharmaceutical formulations employing short-chain sphingolipids and their use
    Patent number: 7915227
    Abstract: Pharmaceutical formulations containing (i) an amphiphilic drug and (ii) a short-chain sphingolipid are described and provided herein along with methods of making and using same.
    Type: Grant
    Filed: November 11, 2004
    Date of Patent: March 29, 2011
    Assignee: Het Nederlands Kanker Instituut
    Inventors: Robert J. Veldman, Wim J. Van Blitterswijk, Marcel Verheij, Gerben A. Koning
  • Pharmaceutical formulations employing short-chain sphingolipids and their use
    Publication number: 20070082855
    Abstract: This invention pertains to pharmaceutical formulations which comprise (i) a drug (e.g., an amphiphilic drug) (e.g., an anthracycline) (e.g., doxorubicin) and (ii) a short-chain sphingolipid (e.g., a short-chain glycosphingolipid or a short-chain sphingomyelin) (e.g., N-octanoyl-glucosylceramide, referred to as C8-GlcCer) (e.g., N-hexanoyl-sphingomyelin, referred to herein as C6-SM), and which provide improved drug delivery and efficacy.
    Type: Application
    Filed: November 11, 2004
    Publication date: April 12, 2007
    Inventors: Robert Veldman, Wim Van Blitterswijk, Marcel Verheij, Gerben Koning