Abstract: The present invention provides SNPs, polymorphic variants, and haplotypes associated with cardiovascular disease. The invention also provides methods for detecting the SNPs, polymorphic variants, and haplotypes. The invention also provides methods for determining an individual's genotype with respect to one or more polymorphisms and/or haplotypes associated with cardiovascular disease. The invention further provides methods of determining whether an individual has or is susceptible to development or occurrence of a cardiovascular disease or event. The methods are useful for providing diagnostic and/or prognostic information, selecting therapeutic regimens, etc. The invention further provides reagents and kits for practicing the methods.

Abstract: The present invention relates to methods for characterizing an individual's risk profile of developing a future cardiovascular disorder by measuring the level of sterols obtained from a individual. The present invention also includes methods of evaluating the likelihood of whether an individual will benefit from treatment with an agent for reducing risk of a future cardiovascular event, such as atherosclerosis, myocardial infarction and stroke.

Abstract: The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly the FHD's such as Tangier Disease

Abstract: The present invention relates to variants of the human apolipoproteine A-I comprising a cystein in position 151, the corresponding nucleic acids and the vectors containing them. It also relates to pharmaceutical compositions comprising said elements and their utilization, particularly in genic therapy.

Abstract: Method of detecting nucleic acids whose nucleotide sequences differ from one another at a position X. The method uses a set of oligonucleotides where the nucleotides found at position X are complementary to a variant nucleic acids only at this position X. However, with respect to the position of another mismatch Y, the nucleotide sequences thereof differ from one another. The invention further addresses reagents for performing the methods as well as reagents and applications of the method.

Abstract: Method of detecting nucleic acids whose nucleotide sequences differ from one another at a position X. The method uses a set of oligonucleotides where the nucleotides found at position X are complementary to a variant nucleic acids only at this position X. However, with respect to the position of another mismatch Y, the nucleotide sequences thereof differ from one another. The invention further addresses reagents for performing the methods as well as reagents and applications of the method.

Abstract: A process and apparatus for the distribution and preparation of samples from primary vessels, especially samples of patients' sera, liquid reagents or the like, which are transferred into fixedly mounted secondary vessels of any desired construction, preferably in accordance with the data from a distribution sheet recorded by a control programming apparatus, where the secondary vessels can be moved into position one after the other by means of a transporting carriage for the primary vessel having an associated diluter, this transporting carriage being movable in the x-y plane by means of two stepping motors, and the primary vessel is brought back into its starting position after each delivery or after delivery of the samples intended for the entire series of samples.

Abstract: A process and apparatus for the distribution and preparation of samples from primary vessels, especially samples of patients' sera, liquid reagents or the like, which are transferred into fixedly mounted secondary vessels of any desired construction, preferably in accordance with the data from a distribution sheet recorded by a control programing apparatus, where the secondary vessels can be moved into position one after the other by means of a transporting carriage for the primary vessel having an associated diluter, this transporting carriage being movable in the x-y plane by means of two stepping motors, and the primary vessel is brought back into its starting position after each delivery or after delivery of the samples intended for the entire series of samples.