Patents by Inventor Gerd Haberhausen

Gerd Haberhausen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9273361
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: March 1, 2016
    Assignees: FUJIREBIO EUROPE N.V., ROCHE DIAGNOSTICS GMBH
    Inventors: Hilde De Henau, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Patent number: 8945850
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: February 3, 2015
    Assignees: Fujirebio Europe N.V., Roche Diagnostics GmbH
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Publication number: 20130130258
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 23, 2013
    Inventors: Hilde DE HENAU, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Patent number: 7981606
    Abstract: The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the test sample, to a negative control sample, to a positive control sample comprising the target biomolecule and providing a reagent control sample comprising the target biomolecule, determining in each sample a signal, and verifying the signal thereby detecting the target biomolecule. The invention is also related to a method for verifying the determination of a signal indicating the presence of a target biomolecule. The invention is further related to a method for detecting the presence or the absence of a member of a group of target nucleic acids in a sample and a method for verifying the determination of a signal indicating the presence of a member of a group of target nucleic acids.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: July 19, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Thomas Emrich, Gerd Haberhausen, Martin Moczko
  • Patent number: 7718361
    Abstract: The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic acid, total DNA or total RNA, (ii) quantifying the amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen, and (iii) determining whether said amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen exceeds a first predetermined cut off value.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: May 18, 2010
    Assignees: Roche Molecular Systems, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ellen J. Baron, Wolf-Dieter Engel, Gerd Haberhausen, Peter Kaspar, Andreas M. Kogelnik
  • Publication number: 20090191558
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S rRNA genes, to be used for the specific detection and/or identification of Serratia species, in particular of Serratia marcescens, Serratia ficaria and/or Serratia fonticola, in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Serratia species, in particular Serratia marcescens, Serratia ficaria and/or Serratia fonticola, using said new nucleic acid sequences derived from the ITS region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Serratia species in a sample.
    Type: Application
    Filed: December 9, 2008
    Publication date: July 30, 2009
    Applicants: Innogenetics, N.V., Roche Diagnostics GmbH
    Inventors: Geert JANNES, Wouter Mijs, Thomas Emrich, Gerd Haberhausen
  • Publication number: 20090098558
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribionucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
    Type: Application
    Filed: October 16, 2008
    Publication date: April 16, 2009
    Applicants: INNOGENETICS N.V., ROCHE DIAGNOSTICS GmbH
    Inventors: Geert Jannes, Wouter Mijs, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20090017456
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Application
    Filed: March 10, 2008
    Publication date: January 15, 2009
    Applicants: INNOGENETICS N.V., ROCHE DIAGNOSTICS GMBH,
    Inventors: Hilde DE HENAU, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20080199878
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 21, 2008
    Applicants: INNOGENETICS N.V., ROCHE DIAGNOSTICS GMBH
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Publication number: 20070141563
    Abstract: The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the test sample, to a negative control sample, to a positive control sample comprising the target biomolecule and providing a reagent control sample comprising the target biomolecule, determining in each sample a signal, and verifying the signal thereby detecting the target biomolecule. The invention is also related to a method for verifying the determination of a signal indicating the presence of a target biomolecule. The invention is further related to a method for detecting the presence or the absence of a member of a group of target nucleic acids in a sample and a method for verifying the determination of a signal indicating the presence of a member of a group of target nucleic acids.
    Type: Application
    Filed: December 12, 2006
    Publication date: June 21, 2007
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Thomas Emrich, Gerd Haberhausen, Martin Moczko
  • Publication number: 20060269914
    Abstract: The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic acid, total DNA or total RNA, (ii) quantifying the amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen, and (iii) determining whether said amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen exceeds a first predetermined cut off value.
    Type: Application
    Filed: December 5, 2003
    Publication date: November 30, 2006
    Inventors: Ellen Baron, Wolf-Dieter Engel, Gerd Haberhausen, Peter Kaspar, Andreas Kogelnik
  • Publication number: 20060240427
    Abstract: The present invention is directed to a method for identification of a Gram positive pathogenic bacterium comprising an amplification step with at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from a first predetermined sub-group of pathogenic Gram positive bacteria, and a detection step with at least a first hybridization reagent capable of specifically detecting a preselected nucleic acid sequence region from the first predetermined sub-group of pathogenic Gram positive bacteria, said detection step comprising steps monitoring whether hybridization has occurred at a preselected temperature, said occurrence of hybridization being indicative for at least the genus of a pathogenic organism present in the sample, and monitoring temperature dependence of hybridization, said temperature dependence being indicative for at least the species of the pathogenic Gram positive bacterium.
    Type: Application
    Filed: December 2, 2003
    Publication date: October 26, 2006
    Applicants: ROCHE MOLECULAR SYSTEMS, INC., INNOGENETICS, N.V.
    Inventors: Gerd Haberhausen, Thomas Emrich, Rudi Rossasu, Geert Jannes, Daniel Vos
  • Patent number: 7105318
    Abstract: Method for the detection of a nucleic acid comprising the production of a plurality of amplificates of a section of this nucleic acid with the aid of two primers, one of which can bind to a binding sequence A of the nucleic acid and the other can bind to a binding sequence C? which is complementary to a sequence C which is located in the 3? direction from A and does not overlap with A, contacting the amplificates with a probe having a binding sequence D which can bind to a sequence B which is located between the sequences A and C or to the complement thereof, and detecting the formation of a hybrid of the amplificate and probe where the sequence located between the binding sequences A and C contains no nucleotides that do not belong to the binding sequence D of the probe or its complement D?.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: September 12, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Christoph Kessler, Gerd Haberhausen, Knut Bartl, Henrik Orum
  • Publication number: 20060134618
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 22, 2006
    Inventors: Hilde De Henau, Joachim Van Crombruggen, Geert Jannes, Thomas Emrich, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20060115819
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 1, 2006
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Publication number: 20060099596
    Abstract: The present invention is directed to a method for identification of a pathogenic organism from a predetermined group of pathogens, comprising (i) isolating a clinical sample containing at least partially purified nucleic acid, (ii) subjecting at least a first aliquot of said clinical specimen to at least one amplification and detection reaction in one reaction vessel comprising (iia) an amplification step using at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from several or all members of said predetermined group of pathogens, (iib) a detection step using at least 2, 3 or multiple hybridization reagents, said reagents together being capable of specifically detecting a pre-selected nucleic acid sequence region from all members of said group of pathogens, said detection step (iib) comprising steps monitoring hybridization of each of said hybridization reagents at a pre-selected temperature, said hybridization being indicative for at least the genus
    Type: Application
    Filed: December 2, 2003
    Publication date: May 11, 2006
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Gerd Haberhausen, Thomas Emrich, Gregor Sagner, Martin Moczko, Gudrun Schmitz-Agheguian
  • Publication number: 20060099618
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S rRNA genes, to be used for the specific detection and/or identification of Serratia species, in particular of Serratia marcescens, Serratia ficaria and/or Serratia fonticola, in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Serratia species, in particular Serratia marcescens, Serratia ficaria and/or Serratia fonticola, using said new nucleic acid sequences derived from the ITS region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Serratia species in a sample.
    Type: Application
    Filed: September 29, 2005
    Publication date: May 11, 2006
    Applicants: Innogenetics, N.V., Roche Diagnostics GmbH
    Inventors: Geert Jannes, Wouter Mijs, Thomas Emrich, Gerd Haberhausen
  • Publication number: 20050176048
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
    Type: Application
    Filed: February 4, 2005
    Publication date: August 11, 2005
    Inventors: Geert Jannes, Wouter Mijs, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20030175765
    Abstract: Method for the detection of a nucleic acid comprising the production of a plurality of amplificates of a section of this nucleic acid with the aid of two primers, one of which can bind to a binding sequence A of the nucleic acid and the other can bind to a binding sequence C′ which is complementary to a sequence C which is located in the 3′ direction from A and does not overlap with A, contacting the amplificates with a probe having a binding sequence D which can bind to a sequence B which is located between the sequences A and C or to the complement thereof, and detecting the formation of a hybrid of the amplificate and probe where the sequence located between the binding sequences A and C contains no nucleotides that do not belong to the binding sequence D of the probe or its complement D′.
    Type: Application
    Filed: December 17, 2002
    Publication date: September 18, 2003
    Inventors: Christoph Kessler, Gerd Haberhausen, Knut Bartl, Henrik Orum
  • Patent number: 6248522
    Abstract: The invention concerns a method for the amplification of nucleic acids using a reagent which prevents reactivation of degradation enzymes. This enables a simpler prevention of contaminations.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: June 19, 2001
    Assignee: Roche Diagnostics GmbH
    Inventors: Gerd Haberhausen, Stephan J├Ąger, Harald Sobek