Patents by Inventor Gerd Lüdke
Gerd Lüdke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11447737Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.Type: GrantFiled: April 2, 2018Date of Patent: September 20, 2022Assignee: CURETIS GMBHInventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
-
Publication number: 20180291331Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.Type: ApplicationFiled: April 2, 2018Publication date: October 11, 2018Inventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
-
Patent number: 9963670Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.Type: GrantFiled: July 27, 2011Date of Patent: May 8, 2018Assignee: Curetis GmbHInventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
-
Publication number: 20170100719Abstract: Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part.Type: ApplicationFiled: December 21, 2016Publication date: April 13, 2017Applicant: BIOCARTIS NVInventors: Chris VAN HAAG, Michiel Johannes JONGERIUS, Danny Genius Aldegonda SCHAEFER, Adrianus Wilhelmus Dionisius Maria VAN DEN BIJGAART, Ronald DE GIER, Michiel DE JONG, Gerhard PROSS, Johannes BACHER, Andreas BOOS, Gerd LUEDKE, Jens-Peter SEHER
-
Patent number: 9598721Abstract: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety of different sample types, such as different types of bodily samples relevant for the diagnosis of a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis.Type: GrantFiled: May 9, 2011Date of Patent: March 21, 2017Assignee: Curetis GmbHInventors: Matthias Klein, Gerd Lüdke, Andreas Boos
-
Patent number: 9592511Abstract: The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state.Type: GrantFiled: May 19, 2011Date of Patent: March 14, 2017Assignee: Curetis GmbHInventors: Gerd Lüdke, Andreas Boos, Hassan Motejadded, Johannes Bacher
-
Patent number: 9568424Abstract: Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.Type: GrantFiled: June 16, 2006Date of Patent: February 14, 2017Assignee: BIOCARTIS NVInventors: Chris Van Haag, Michiel Johannes Jongerius, Danny Genius Aldegonda Schaefer, Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart, Ronald De Gier, Michiel De Jong, Gerhard Pross, Johannes Bacher, Andreas Boos, Gerd Luedke, Jens-Peter Seher
-
Publication number: 20140242678Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.Type: ApplicationFiled: July 27, 2011Publication date: August 28, 2014Inventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
-
Publication number: 20130130267Abstract: The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state.Type: ApplicationFiled: May 19, 2011Publication date: May 23, 2013Inventors: Gerd Lüdke, Andreas Boos, Hassan Motejadded, Johannes Bacher
-
Publication number: 20130065223Abstract: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety o different sample types, such as different types of bodily samples relevant for the diagnosis o a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis.Type: ApplicationFiled: May 9, 2011Publication date: March 14, 2013Applicant: CURETIS AGInventors: Matthias Klein, Gerd Lüdke, Andreas Boos
-
Publication number: 20100047774Abstract: Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.Type: ApplicationFiled: June 16, 2006Publication date: February 25, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Chris Van Haag, Michiel Johannes Jongerius, Danny Genius Aldegonda Schaefer, Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart, Ronald De Gier, Michiel De Jong, Gerhard Pross, Johannes Bacher, Andreas Boos, Gerd Luedke, Jens-Peter Seher
-
Publication number: 20080311668Abstract: Disclosed is the detection of a target nucleic acid sequence in a mixture of different nucleic acids having additional binding sites, by: hybridizing the target nucleic acid sequence with a probe in liquid phase, the probe having a first label. The additional binding sites are hybridized with single stranded nucleic acids having random primary sequences in liquid phase, the different nucleic acids are separated, and the target nucleic acid is detected by using the labeled probe.Type: ApplicationFiled: November 17, 2003Publication date: December 18, 2008Inventor: Gerd Luedke
-
Publication number: 20080312105Abstract: Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.Type: ApplicationFiled: December 15, 2006Publication date: December 18, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Johannes Bacher, Andreas Boos, Gerd Luedke
-
Publication number: 20080300144Abstract: Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.Type: ApplicationFiled: December 13, 2006Publication date: December 4, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Johannes Bacher, Andreas Boos, Gerd Luedke
-
Publication number: 20080269069Abstract: Disclosed is a method for performing a microarray assay on one or more sample fluid(s), said fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.Type: ApplicationFiled: December 11, 2006Publication date: October 30, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Johannes Bacher, Andreas Boos, Gerd Luedke
-
Publication number: 20070246362Abstract: A method for processing analytes in a first solution containing charged particles, wherein the first solution is filling a compartment having reservoirs. The compartment is subjected to an electric field, so that the charged particles are mainly moved into the reservoirs, thereby reducing the amount of the charged particles in a part of the first solution, which is located in a section of the compartment. The part of the first solution obtained in A) containing the analytes is then subjected to further processing.Type: ApplicationFiled: February 2, 2004Publication date: October 25, 2007Applicant: AGILENT TECHNOLOGIES INC.Inventor: Gerd Luedke
-
Publication number: 20070161118Abstract: A method for mixing at least two fluids comprising: (a) introducing the at least two fluids into a common first conduit which includes a junction with a second conduit and transporting the fluids to the junction, (b) subjecting the fluids in the first conduit at the junction to a force in order to alternately change the direction of flow of the fluids.Type: ApplicationFiled: January 29, 2004Publication date: July 12, 2007Inventors: Gerd Luedke, Andreas Ruefer
-
Publication number: 20030073136Abstract: Analyte cells with different properties flow through a flow cytometric detector arrangement. The number of analyte cells having the different properties is determined. To compensate for errors due to two or more analyte cells being simultaneously in the cytometric cell, the actual number of analyte cells with a specific property is calculated from the measured values of cells with this specific property by using a statistical model about the probability of simultaneous occurrences of cells in the cytometric cell. A data processing arrangement has a memory including the model and receives as input data the measured analyte cell numbers and uses an experimentally determined coincidence rate for calculating actual analyte cell numbers.Type: ApplicationFiled: October 17, 2002Publication date: April 17, 2003Inventors: Gerd Luedke, Bernd Nawracala
-
Patent number: D683044Type: GrantFiled: December 21, 2011Date of Patent: May 21, 2013Assignee: Curetis AGInventors: Matthias Klein, Gerd Lüdke, Andreas Boos