Abstract: The present invention describes a method for producing de novo papillae comprising the steps of a) providing isolated dermal papilla fibroblasts (DPF) from at least one dermal papilla (DP) from at least one hair follicle, b) providing isolated connective tissue sheath fibroblasts (CTSF) from at least one hair follicle and c) co-culturing the DPF with the CTSF under substantially non-adherent cell culture conditions to form spheroid cell aggregates.

Abstract: A method for producing a skin equivalent comprising the steps of: a) producing a dermal matrix containing a first layer and a second layer comprises the steps of i) providing the first layer; ii) providing a polymerizable solution comprising a liquid and at least one polymer; iii) adding the polymerizable solution to the first layer; iv) polymerizing the solution to form the second layer; v) compressing the second layer, wherein as a result of the compression the liquid content of the second layer is reduced and the first layer and second layer are joined together to form the dermal matrix; and vi) introducing at least one cavity into the dermal matrix; b) introducing at least one hair follicle and/or hair follicle germ into the at least one cavity of the dermal matrix produced in step a) to produce a skin surrogate; and c) adding at least one further cell population.

Abstract: The present invention describes a method for producing de novo papillae comprising the steps of a) providing isolated dermal papilla fibroblasts (DPF) from at least one dermal papilla (DP) from at least one hair follicle, b) providing isolated connective tissue sheath fibroblasts (CTSF) from at least one hair follicle and c) co-culturing the DPF with the CTSF under substantially non-adherent cell culture conditions to form spheroid cell aggregates.

Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novo papillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novo papillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.

Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.

Abstract: An air conditioning system is provided, particularly for a vehicle having a main air conditioning unit, an auxiliary air conditioning unit, wherein both the main air conditioning unit and the auxiliary air conditioning unit contain a blower, an evaporator and a heater core, a cold pass is attached to the evaporator, a hot pass is affiliated to the heater core and the cold pass is separated from the hot pass by at least one temperature door. By an air conditioning system, especially for a vehicle, which uses the conditioned air in the vehicle cabin for engine cooling, an additional pass is arranged before the heater core in the auxiliary air conditioning unit wherein said hot pass ends in a body exhauster during the cooling mode of said auxiliary air conditioning unit.

Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novo papillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novo papillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.

Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novopapillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novopapillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.

Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.

Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novopapillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novopapillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.

Abstract: A blower assembly for use with an HVAC module is provided. The blower assembly includes a scroll or volute shaped housing having an air inlet in a wall of the housing for receiving air to be blown by an impeller, and an air outlet from which the blown air passes from the housing. A blower wheel is secured to a rotatable motor-driven shaft extending along a central axis of the air inlet. At least one venture is provided adjacent to the air inlet of the housing, the at least one venturi connectable to an aspirator that is in fluid communication with a sensor unit. Wherein, during operation, the blower wheel pulls air both through the air inlet to the housing and through the at least one venturi.

Abstract: A blower scroll comprising a base and a wall extending from an outer edge of the base. The base may include an outlet formed in the base a diverting device extending about at least a portion of the outlet. The diverting device may obstruct the flow of water droplets in the blower scroll into the outlet.