Patents by Inventor Gerd Luedke

Gerd Luedke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180291331
    Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.
    Type: Application
    Filed: April 2, 2018
    Publication date: October 11, 2018
    Inventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
  • Patent number: 9963670
    Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: May 8, 2018
    Assignee: Curetis GmbH
    Inventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
  • Publication number: 20170100719
    Abstract: Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part.
    Type: Application
    Filed: December 21, 2016
    Publication date: April 13, 2017
    Applicant: BIOCARTIS NV
    Inventors: Chris VAN HAAG, Michiel Johannes JONGERIUS, Danny Genius Aldegonda SCHAEFER, Adrianus Wilhelmus Dionisius Maria VAN DEN BIJGAART, Ronald DE GIER, Michiel DE JONG, Gerhard PROSS, Johannes BACHER, Andreas BOOS, Gerd LUEDKE, Jens-Peter SEHER
  • Patent number: 9598721
    Abstract: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety of different sample types, such as different types of bodily samples relevant for the diagnosis of a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: March 21, 2017
    Assignee: Curetis GmbH
    Inventors: Matthias Klein, Gerd Lüdke, Andreas Boos
  • Patent number: 9592511
    Abstract: The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: March 14, 2017
    Assignee: Curetis GmbH
    Inventors: Gerd Lüdke, Andreas Boos, Hassan Motejadded, Johannes Bacher
  • Patent number: 9568424
    Abstract: Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: February 14, 2017
    Assignee: BIOCARTIS NV
    Inventors: Chris Van Haag, Michiel Johannes Jongerius, Danny Genius Aldegonda Schaefer, Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart, Ronald De Gier, Michiel De Jong, Gerhard Pross, Johannes Bacher, Andreas Boos, Gerd Luedke, Jens-Peter Seher
  • Publication number: 20140242678
    Abstract: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample.
    Type: Application
    Filed: July 27, 2011
    Publication date: August 28, 2014
    Inventors: Andreas Boos, Gerd Lüdke, Johannes Bacher
  • Publication number: 20130130267
    Abstract: The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state.
    Type: Application
    Filed: May 19, 2011
    Publication date: May 23, 2013
    Inventors: Gerd Lüdke, Andreas Boos, Hassan Motejadded, Johannes Bacher
  • Publication number: 20130065223
    Abstract: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety o different sample types, such as different types of bodily samples relevant for the diagnosis o a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis.
    Type: Application
    Filed: May 9, 2011
    Publication date: March 14, 2013
    Applicant: CURETIS AG
    Inventors: Matthias Klein, Gerd Lüdke, Andreas Boos
  • Publication number: 20100047774
    Abstract: Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
    Type: Application
    Filed: June 16, 2006
    Publication date: February 25, 2010
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Chris Van Haag, Michiel Johannes Jongerius, Danny Genius Aldegonda Schaefer, Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart, Ronald De Gier, Michiel De Jong, Gerhard Pross, Johannes Bacher, Andreas Boos, Gerd Luedke, Jens-Peter Seher
  • Publication number: 20080312105
    Abstract: Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
    Type: Application
    Filed: December 15, 2006
    Publication date: December 18, 2008
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Johannes Bacher, Andreas Boos, Gerd Luedke
  • Publication number: 20080311668
    Abstract: Disclosed is the detection of a target nucleic acid sequence in a mixture of different nucleic acids having additional binding sites, by: hybridizing the target nucleic acid sequence with a probe in liquid phase, the probe having a first label. The additional binding sites are hybridized with single stranded nucleic acids having random primary sequences in liquid phase, the different nucleic acids are separated, and the target nucleic acid is detected by using the labeled probe.
    Type: Application
    Filed: November 17, 2003
    Publication date: December 18, 2008
    Inventor: Gerd Luedke
  • Publication number: 20080300144
    Abstract: Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.
    Type: Application
    Filed: December 13, 2006
    Publication date: December 4, 2008
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Johannes Bacher, Andreas Boos, Gerd Luedke
  • Publication number: 20080269069
    Abstract: Disclosed is a method for performing a microarray assay on one or more sample fluid(s), said fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.
    Type: Application
    Filed: December 11, 2006
    Publication date: October 30, 2008
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Johannes Bacher, Andreas Boos, Gerd Luedke
  • Publication number: 20070246362
    Abstract: A method for processing analytes in a first solution containing charged particles, wherein the first solution is filling a compartment having reservoirs. The compartment is subjected to an electric field, so that the charged particles are mainly moved into the reservoirs, thereby reducing the amount of the charged particles in a part of the first solution, which is located in a section of the compartment. The part of the first solution obtained in A) containing the analytes is then subjected to further processing.
    Type: Application
    Filed: February 2, 2004
    Publication date: October 25, 2007
    Applicant: AGILENT TECHNOLOGIES INC.
    Inventor: Gerd Luedke
  • Publication number: 20070161118
    Abstract: A method for mixing at least two fluids comprising: (a) introducing the at least two fluids into a common first conduit which includes a junction with a second conduit and transporting the fluids to the junction, (b) subjecting the fluids in the first conduit at the junction to a force in order to alternately change the direction of flow of the fluids.
    Type: Application
    Filed: January 29, 2004
    Publication date: July 12, 2007
    Inventors: Gerd Luedke, Andreas Ruefer
  • Publication number: 20030073136
    Abstract: Analyte cells with different properties flow through a flow cytometric detector arrangement. The number of analyte cells having the different properties is determined. To compensate for errors due to two or more analyte cells being simultaneously in the cytometric cell, the actual number of analyte cells with a specific property is calculated from the measured values of cells with this specific property by using a statistical model about the probability of simultaneous occurrences of cells in the cytometric cell. A data processing arrangement has a memory including the model and receives as input data the measured analyte cell numbers and uses an experimentally determined coincidence rate for calculating actual analyte cell numbers.
    Type: Application
    Filed: October 17, 2002
    Publication date: April 17, 2003
    Inventors: Gerd Luedke, Bernd Nawracala
  • Patent number: D683044
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: May 21, 2013
    Assignee: Curetis AG
    Inventors: Matthias Klein, Gerd Lüdke, Andreas Boos