Abstract: The present invention discloses a process for engineering a host cell comprising the steps of; a) integrating a first polynucleotide cassette including a first selection marker flanked by a first pair of recombination sites; b) removing the first selection marker by the action of a recombinase which recognises the first pair of recombination sites; c) integrating a second polynucleotide cassette including a second selection marker flanked by a second pair of recombination sites; and d) removing the second selection marker by the action of a recombinase which recognises the second pair of recombination sites. Also disclosed is a host cell genome polynucleotide comprising a first recombinantly engineered region and a second recombinantly engineered region, wherein a first single recombination site is adjacent to the first recombinantly engineered region, and a second single recombination site is adjacent to the second recombinantly engineered region.

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?. Also provided are conjugates comprising a ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

Abstract: The present invention relates to the field of immunogenic compositions and vaccines, their manufacture, host cells which can be used in their manufacture and the use of such immunogenic compositions and vaccines in medicine. More particularly, it relates to Klebsiella pneumoniae O-antigens, conjugates comprising a K. pneumoniae O-antigen, host cells suitable for their production and immunogenic compositions or vaccines containing at least one Klebsiella pneumoniae O-antigen.

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?. Also provided are conjugates comprising a ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

Abstract: The present invention discloses a process for engineering a host cell comprising the steps of; a) integrating a first polynucleotide cassette including a first selection marker flanked by a first pair of recombination sites; b) removing the first selection marker by the action of a recombinase which recognises the first pair of recombination sites; c) integrating a second polynucleotide cassette including a second selection marker flanked by a second pair of recombination sites; and d) removing the second selection marker by the action of a recombinase which recognises the second pair of recombination sites. Also disclosed is a host cell genome polynucleotide comprising a first recombinantly engineered region and a second recombinantly engineered region, wherein a first single recombination site is adjacent to the first recombinantly engineered region, and a second single recombination site is adjacent to the second recombinantly engineered region.

Abstract: An enterprise system which facilitates synchronization of offline data. Offline data created during an offline session or sessions (collectively an offline session) prior to synchronization is assigned a temporary key. Changes of offline data created during an offline session is assigned the temporary key of the data to which the change is associated. The temporary key is mapped to a new created backend key and stored in a mapping table. Using the mapping table, temporary keys associated with the changes are swapped with backend keys which the temporary keys are mapped. This maintains data persistency of newly created and change data during an offline session.

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s)?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?.Also provided are conjugates comprising a ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

Abstract: Disclosed herein are system, method, and computer program product embodiments for the detection and resolution of conflicts in data synchronization. An embodiment operates by receiving an upload from a user device of one or more changes to a local copy of a master document. A conflict is identified between the one or more uploaded changes and one or more previous changes to the master document. A super user is notified of the conflict. A resolution of the conflict is received. The resolution to resolve the conflict is applied.

Abstract: Disclosed herein are system, method, and computer program product embodiments for the automatic detection, retry, and resolution of errors in data synchronization. An embodiment operates by receiving one or more changes to a local copy of a master document. An error is detected during a synchronization of the one or more changes with the master document. A count is incremented and the synchronization is retried until either the synchronization completes or a threshold has been reached.

Abstract: An enterprise system which facilitates synchronization of offline data. Offline data created during an offline session or sessions (collectively an offline session) prior to synchronization is assigned a temporary key. Changes of offline data created during an offline session is assigned the temporary key of the data to which the change is associated. The temporary key is mapped to a new created backend key and stored in a mapping table. Using the mapping table, temporary keys associated with the changes are swapped with backend keys which the temporary keys are mapped. This maintains data persistency of newly created and change data during an offline session.

Abstract: An enterprise system which facilitates synchronization of offline data. Offline data created during an offline session or sessions (collectively an offline session) prior to synchronization is assigned a temporary key. Changes of offline data created during an offline session is assigned the temporary key of the data to which the change is associated. The temporary key is mapped to a new created backend key and stored in a mapping table. Using the mapping table, temporary keys associated with the changes are swapped with backend keys which the temporary keys are mapped. This maintains data persistency of newly created and change data during an offline session.

Abstract: A bearing arrangement for a driver's cab of a lorry is disclosed. The bearing arrangement has a respective frame-side bracket which is fastened to a laterally associated frame element of a support frame of the lorry and which has a guide, along which an allocated bearing element of a driver's cab bearing can be displaced in the event of an accident-induced application of force. The bearing element is connected to the laterally allocated frame element of the support frame via a weakening device by which the laterally allocated frame element of the support frame can be weakened in a targeted manner in the event of an accident-induced displacement of the bearing element.

Abstract: An enterprise system which facilitates synchronization of offline data. Offline data created during an offline session or sessions (collectively an offline session) prior to synchronization is assigned a temporary key. Changes of offline data created during an offline session is assigned the temporary key of the data to which the change is associated. The temporary key is mapped to a new created backend key and stored in a mapping table. Using the mapping table, temporary keys associated with the changes are swapped with backend keys which the temporary keys are mapped. This maintains data persistency of newly created and change data during an offline session.

Abstract: Disclosed herein are system, method, and computer program product embodiments for the automatic detection, retry, and resolution of errors in data synchronization. An embodiment operates by receiving one or more changes to a local copy of a master document. An error is detected during a synchronization of the one or more changes with the master document. A count is incremented and the synchronization is retried until either the synchronization completes or a threshold has been reached.

Abstract: A packaging machine is disclosed that includes a deep-drawing station, a filling station, a sealing station, or a combination thereof. The deep-drawing station, the sealing station, or both have an upper tool including a supporting top part. The supporting top is pivotable via a pivot mechanism, and the pivot mechanism is detachable from the supporting top part.

Abstract: A computer-implemented system may include an application platform comprising a platform model of a plurality of business objects, each of the business objects comprising a model of data and associated logic, and a public solution model comprising a subset of the platform model. The system may also include a business application, wherein a data model and access logic of the business application are defined based on the public solution model, and wherein the application platform is to provide services to the business application based on the data model, the access logic and the platform model.

Abstract: A computer-implemented system may include reception of a user interface request corresponding to two or more chained operations associated with one or more service calls to a backend service layer, determination of whether to update a backend buffer after execution of each of the one or more service calls, execution, if it is determined to update the backend buffer after execution of each of the one or more service calls, of each of the one or more service calls, and a read service call after execution of each of the one or more service calls, and execution, if it is determined not to update the backend buffer after execution of each of the one or more service calls, of each of the one or more service calls in sequence, and a bulk read service call only after execution of all of the one or more service calls.

Abstract: A computer-implemented system may include a data store to store business data, an application platform, and a business application. The application platform may include a repository to store metadata defining a plurality of business objects, each of the business objects comprising a respective model of data and associated logic, each business object associated with respective business object entities, and a framework in communication with the repository to provide access to the business data. The business application is to access the data via the framework and based on the metadata, wherein the metadata associates a first plurality of the business object entities with a RELEASED release status code, and wherein the metadata associates a second plurality of the business object entities with a DEPRECATED release status code.

Abstract: The invention relates to a method for changing the upper and lower tool of a packaging machine. The invention further relates to a packaging machine.

Abstract: A computer-implemented system may include reception of a user interface request corresponding to two or more chained operations associated with one or more service calls to a backend service layer, determination of whether to update a backend buffer after execution of each of the one or more service calls, execution, if it is determined to update the backend buffer after execution of each of the one or more service calls, of each of the one or more service calls, and a read service call after execution of each of the one or more service calls, and execution, if it is determined not to update the backend buffer after execution of each of the one or more service calls, of each of the one or more service calls in sequence, and a bulk read service call only after execution of all of the one or more service calls.