Abstract: ABC multidrug transporters are key players in cancer multidrug resistance and in general xenobiotic elimination, thus their functional assays provide important tools for research and diagnostic applications. It has been found that in cells expressing functional ABCG2, ABCB1, or ABCC1 transporters, cellular PG fluorescence is strongly reduced. The invention relates to methods and uses of fluorescein derivative ester compounds of formula Ia which are analogs of PG for assessing ABC transporter activity of ABC multidrug transporters. The present accumulation assay is a novel tool for the parallel determination of the function of the multidrug transporters, in particular ABCG2, ABCB1, and ABCC1. The assay is applicable for diagnostic purposes and also allows the selection, separation and culturing of selected cell populations expressing such transporters.

Abstract: A technique for handling messages generated in an industrial control procedure by a first device for being transmitted via a communication network towards a second device is presented, wherein the first device is one of a field device and a field device controller and the second device is the other one of the field device and the field device controller. A method implementation of the technique comprises intercepting a first message generated by the first device, wherein the first message is intercepted before the communication network towards the second device, and wherein the first message has a first message content. The method also comprises storing the first message content and forwarding the first message content on the communication network towards the second device.

Abstract: The brake system for motor vehicles has a brake pedal unit having a sensor, which has an intelligence of its own in the form of an electronic processing unit, which directly calculates actuating signals for brake actuators. Furthermore, the brake system has a central electronic control unit, which ascertains actuating signals for the actuators on the basis of an analog or digital signal of the mentioned sensor or of an additional sensor. The actuators have an intelligence of their own in the form of an electronic processing unit, which verifies whether the actuating signal coming from the central electronic control unit is valid. If this is the case, then the actuators are controlled by this signal, otherwise on the basis of the actuating signal calculated by the sensor.

Abstract: A method and system for managing IPsec Security Associations in a Security Association Database (SADB) in an IP network is described. At a key management application, a domain extension header is inserted into a PF_KEY message containing instructions to a key engine unit. The domain extension header identifies a domain within the Security Association Database. The PF_KEY message is sent to the key engine unit, which carries out the instructions only for Security Associations in the domain of the Security Association Database indicated by the domain extension header.

Abstract: A method of handling performance data comprising a set of events is described. An event record for each event is stored as a set of blocks, each block containing one or more attributes of the event. The storage space occupied by each event record in is then reduced in discrete steps, each step including a reduction process that reduces the size of one of the set of blocks. This enables the provision of intermediate records between events and counters so that new event records contain complete details of their event, older event records contain less information, and even older event records may contain only high-level (counter) information.

Abstract: Methods of processing record data are presented, together with a Central Management Node for processing record data, and Management Subsystem DataBases for providing a record data set and matching record data. Triggered by service related network fault event, a key table comprising at least one key type is determined, based on a focus target record and related to the network fault event is determined, which key table is used in the step matching the at least one key with record data sets in determined Management Subsystem DataBases. Matched results are merged, whereafter a service performance indicator may be determined, based on which a multi-layer water flow analysis of subsystem specific performance related indicators can be obtained. This analysis may be successfully used to reveal the location of the service related network fault.

Abstract: A method and system for managing IPsec Security Associations in a Security Association Database (SADB) in an IP network is described. At a key management application, a domain extension header is inserted into a PF_KEY message containing instructions to a key engine unit. The domain extension header identifies a domain within the Security Association Database. The PF_KEY message is sent to the key engine unit, which carries out the instructions only for Security Associations in the domain of the Security Association Database indicated by the domain extension header.

Abstract: A system and method of handling poll-based alarms. The method begins by detecting a high-priority problem in a network. Next, network elements in the network related to the high-priority problem are mapped. The mapping step includes grouping network elements into focus groups wherein each focus group includes network elements having the same alarm. The mapped network elements are then polled for alarms. The polled alarms of the network elements are then correlated and processed.

Abstract: A method and apparatus for querying an IPsec Security Policy Database comprising a plurality of groups of Security Policies that have been assigned a priority value. When a network node receives an IP packet, it determines a priority value and looks for Security Policies in the Security Policy Database having that priority value. If no Security Policies are found, then it looks for Security Policies having a lower priority value. This process is repeated until a Security Policy is found, in which case it is returned and applied to the IP packet, or it is determined that no suitable Security Policy exists.

Abstract: A method of handling performance data comprising a set of events is described. An event record for each event is stored as a set of blocks, each block containing one or more attributes of the event. The storage space occupied by each event record in is then reduced in discrete steps, each step including a reduction process that reduces the size of one of the set of blocks. This enables the provision of intermediate records between events and counters so that new event records contain complete details of their event, older event records contain less information, and even older event records may contain only high-level (counter) information.

Abstract: The brake system for motor vehicles has a brake pedal unit having a sensor, which has an intelligence of its own in the form of an electronic processing unit, which directly calculates actuating signals for brake actuators. Furthermore, the brake system has a central electronic control unit, which ascertains actuating signals for the actuators on the basis of an analog or digital signal of the mentioned sensor or of an additional sensor. The actuators have an intelligence of their own in the form of an electronic processing unit, which verifies whether the actuating signal coming from the central electronic control unit is valid. If this is the case, then the actuators are controlled by this signal, otherwise on the basis of the actuating signal calculated by the sensor.

Abstract: A trailer electronic braking system is provided for a road train having a tractor and a plurality of trailers. The braking system includes a braking ECU on each trailer and a communication interface being provided so that the braking ECU on a first trailer and the braking ECU on a second trailer are able to communicate with one another. In use, the respective braking ECU on the first and second trailer receive an input from a respective sensor on the first and second trailer adapted to detect lateral acceleration and/or wheel speed. In the event that one of the sensors detects lateral acceleration and/or a wheel speed indicative of a loss of stability, the sensor generates a signal for actuating stability control, which signal is passed via the communication interface to the braking ECU on the other trailer, so that the other trailer can actuate stability control.

Abstract: Methods of processing record data are presented, together with a Central Management Node for processing record data, and Management Subsystem DataBases for providing a record data set and matching record data. Triggered by service related network fault event, a key table comprising at least one key type is determined, based on a focus target record and related to the network fault event is determined, which key table is used in the step matching the at least one key with record data sets in determined Management Subsystem Databases. Matched results are merged, whereafter a service performance indicator may be determined, based on which a multi-layer water flow analysis of subsystem specific performance related indicators can be obtained. This analysis may be successfully used to reveal the location of the service related network fault.

Abstract: A system and method of handling poll-based alarms. The method begins by detecting a high-priority problem in a network. Next, network elements in the network related to the high-priority problem are mapped. The mapping step includes grouping network elements into focus groups wherein each focus group includes network elements having the same alarm. The mapped network elements are then polled for alarms. The polled alarms of the network elements are then correlated and processed.

Abstract: A trailer electronic braking system for a road train includes a tractor and a plurality of trailers. The braking system includes a braking ECU on at least one trailer and an ABS system on a further trailer. A communication interface is provided so that the braking ECU on a first trailer and the ABS control unit on a second trailer are able to communicate with one another. In use, the braking ECU on the first trailer receives an input from a respective sensor on the first trailer adapted to detect lateral acceleration anchor wheel speed. In the event that the sensor detects lateral acceleration anchor a wheel speed indicative of a loss of stability, the sensor generates a signal for actuating stability control, which signal is passed via the communication interface to the ABS control unit on the other trailer, so that the other trailer can actuate the brakes on that trailer.

Abstract: A trailer electronic braking system is provided for a road train having a tractor and a plurality of trailers. The braking system includes a braking ECU on each trailer and a communication interface being provided so that the braking ECU on a first trailer and the braking ECU on a second trailer are able to communicate with one another. In use, the respective braking ECU on the first and second trailer receive an input from a respective sensor on the first and second trailer adapted to detect lateral acceleration and/or wheel speed. In the event that one of the sensors detects lateral acceleration and/or a wheel speed indicative of a loss of stability, the sensor generates a signal for actuating stability control, which signal is passed via the communication interface to the braking ECU on the other trailer, so that the other trailer can actuate stability control.

Abstract: The brakes of the front axle of the trailer of a utility vehicle are impinged upon with a brake pressure by way of a single, common ABS valve. Said ABS valve is electrically actuated by an EBS module associated with the rear wheel brakes depending on a differential slip between the front axle and the rear axle.

Abstract: The invention relates to a method for redundantly estimating, i.e. by various sub-methods, the risk of lateral overturn of a vehicle. One sub-method involves estimating the risk of overturn according to the actual braking state of the vehicle—braking or strong braking, or not braking or slight braking—by monitoring the rotational speed behavior of the wheels on the inside of the turn. Another sub-method involves pre-calculating the rolling motion of the vehicle about the longitudinal axis thereof over a short time span of, for example, 0.5 s to 1.5 s on the basis of instantaneous movement parameters and assessing the risk of overturn on the basis of the anticipated rolling motion.

Abstract: The brakes of the front axle of the trailer of a utility vehicle are impinged upon with a brake pressure by way of a single, common ABS valve. Said ABS valve is electrically actuated by an EBS module associated with the rear wheel brakes depending on a differential slip between the front axle and the rear axle.

Abstract: The invention relates to a method for redundantly estimating, i.e. by means of various sub-methods, the risk of lateral overturn of a vehicle. One sub-method involves estimating the risk of overturn according to the actual braking state of the vehicle—braking or strong braking, or not braking or slight braking—by monitoring the rotational speed behavior of the wheels on the inside of the turn. Another sub-method involves pre-calculating the rolling motion of the vehicle about the longitudinal axis thereof over a short time span of, for example, 0.5 s to 1.5 s on the basis of instantaneous movement parameters and assessing the risk of overturn on the basis of the anticipated rolling motion.