Abstract: A carrying axle (1) for trailers and a method for the production thereof are provided. The axle (1) includes an axle body (4) having an outer supporting axle tube (10) in which a rocker arm assembly (6), which is bent once or several times, is introduced. The rocker arm assembly (6) is produced as a metal, tubular stamped and bent single piece. The rocker arm assembly is stamped from a platine (21) or a sheet metal strip (23) and is bent in order to form an angled tube (22).

Abstract: A carrying axle (1) for trailers and a method for the production thereof are provided. The axle (1) includes an axle body (4) having an outer supporting axle tube (10) in which a rocker arm assembly (6), which is bent once or several times, is introduced. The rocker arm assembly (6) is produced as a metal, tubular stamped and bent single piece. The rocker arm assembly is stamped from a platine (21) or a sheet metal strip (23) and is bent in order to form an angled tube (22).

Abstract: Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or —NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.

Abstract: In a metering apparatus for the metered introduction of a first medium into an exhaust gas system of an internal combustion engine, which includes a conditioning apparatus in which also a second medium is introduced via a dispensing apparatus which is connected to the conditioning apparatus and via which the first medium and the second medium are introduced into the exhaust gas system, a supply unit for supplying a third medium, which is different from the second medium in its physical properties and/or its chemical composition, is connected to the conditioning apparatus for cleaning of the conditioning apparatus and the dispensing apparatus from constituent parts of the first medium by the third medium or a mixture of the second and the third medium.

Abstract: The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides of the formula I, in which the anions X are physiologically acceptable anions, and their analogs, which are effective inhibitors of the blood coagulation factor Xa and which can be used, for example, for preventing thromboses. The process according to the invention comprises the coupling of 2-[2-acetylamino-3-(4-amidinophenyl)propionylamino]-2-cyclohexylacetic acid, which is obtained from 2-[2-acetylamino-3-(4-cyanophenyl)acryloylamino]-2-cyclohexylacetic acid by asymmetric hydrogenation and conversion of the cyano group into the amidine, or a salt thereof, with a 3-(2-amino-2-carbamoylethyl)-1-methylpyridinium salt or a salt thereof. The invention furthermore provides starting materials and intermediates for this process, processes for their preparation and acetyl-(S)-4-amidiniophenylalanyl-(S)-cyclohexylglycyl-(S)-(1-methyl-3-pyridinio)alaninamide as ditosylate salt.

Abstract: The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides of the formula I, 1

Abstract: A process for the preparation of manganese complexes of salen compounds which comprises carrying out the reaction of a salen compound with a manganese compound in DMF is described. In a preferred embodiment, the salen compound itself is synthesised likewise in DMF and reacted without intermediate isolation to form the manganese complex.

Abstract: A process for the preparation of manganese complexes of salen compounds which comprises carrying out the reaction of a salen compound with a manganese compound in DMF is described. In a preferred embodiment, the salen compound itself is synthesised likewise in DMF and reacted without intermediate isolation to form the manganese complex.

Abstract: The present invention relates to ethyl 3-(2-(4-(4-(amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate salts of the formula I, in which HM is maleic acid, and to their physiologically tolerated salts, thereof, to processes for their preparation and to their use in pharmaceuticals.

Abstract: The present invention relates to a process for the preparation of chiral, nonracemic compounds of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings indicated in claim 1 and which are useful intermediates for the preparation of pharmaceutical active compounds in which, for resolution, a salt is formed from the racemic compound of the formula I and a chiral, nonracemic amino compound. It furthermore relates to compounds of the formula I and esters thereof.

Abstract: Process for the resolution of rac-2-oxotricyclo?2.2.1.0.sup.3,5 !heptane-7-carboxylic acid esters using lipase from candida.Compounds of the formula I ##STR1## in which R.sup.1 has the meanings mentioned, may be obtained in isomerically pure form from enantiomer mixtures or racemic mixtures by reacting the compound of the formula I in the presence of a lipase or esterase from porcine liver, porcine pancreas, bovine pancreas or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus, or proteases from Bacillus in the presence of water and, if desired, a cosolvent and separating from one another the esters and acids present in the solution obtained.

Abstract: Compounds of the formula I ##STR1## can be prepared in a multi-day process starting from the compounds of the formulae II and IIIR.sup.1 --SH, II ##STR2## where the substituents R.sup.1, R.sup.2 and R.sup.3 have the meanings given.

Abstract: Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acidsCompounds of the formula I ##STR1## in which R.sup.1 and R.sup.2 are as defined can be prepared stereoselectively by reaction of acrylic acid or derivatives thereof or propionic acid or derivatives thereof with a chiral auxiliary, reaction with a mercaptan, stereoselective alkylation and subsequent hydrolysis and oxidation.

Abstract: A novel process is described for preparing tert-butyl (3R, 5S ) 6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate of the formula I ##STR1## which is a valuable structural element for preparing inhibitors of HMG-CoA reductase.

Abstract: 4-Hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors.Compounds of the formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings indicated, and also their pharmacologically tolerable salts with bases and their pharmacologically tolerable esters, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. In addition, compounds of the formula III ##STR3## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y have the meanings indicated are described.

Abstract: The invention relates to a process for the preparation of a metal complex dye under production conditions, which comprises reacting at least one dye with a metal donor, adding said metal donor or said dye discontinuously before the end point of the metallizing is reached, and determining the end of the metallizing voltametrically.The process makes it possible to prepare metal complex dyes in good yield and purity.

Abstract: 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II ##STR1## in which R.sup.1 and R.sup.2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

Abstract: Substituted 3-thia- and 3-oxa-alkylflavones of formula I ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.

Abstract: 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds, their use as pharmaceuticals, pharmaceutical preparations and novel phenols and thiophenols Compounds of the general formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y and Z have the meanings given, and pharmacologically tolerated salts thereof with bases and pharmacologically tolerated esters thereof, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z have the meanings given, are also described.

Abstract: 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids, 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyheptanoic acids of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the indicated meanings, and the corresponding .delta.-lactones of the formula II ##STR2## processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.