Patents by Inventor Gerhard Bienhaus
Gerhard Bienhaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7537935Abstract: A process and closure arrangement is provided for isolating purified biological material. The process includes placing biological materials in separate lysis vessels, adding lysis liquids to the biological materials in the lysis vessels, and transferring the liquids in the lysis vessels into a matrix unit. The liquids in the matrix vessels of the matrix unit are extracted through outlet openings during which the liquids flow through matrices and the matrix unit is placed on a collecting unit with collecting vessels which are arranged such that at least the outlet openings of the matrix vessels extend into the collecting vessels. The matrix vessels are with elution fluid and elution fluids from the matrix vessels are extracted through their outlet openings during which the elution fluids flow through the matrices and the elution fluids which are enriched with biological material are collected in the collecting vessels.Type: GrantFiled: October 27, 2003Date of Patent: May 26, 2009Assignee: Roche Molecular Systems, Inc.Inventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Thomas Walter
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Patent number: 6919175Abstract: A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.Type: GrantFiled: April 26, 2000Date of Patent: July 19, 2005Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Ulrich Schubert, Uwe Kolb, Burkhard Stolz, Manfred Pasch
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Publication number: 20040092030Abstract: A process and closure arrangement is provided for isolating purified biological material. The process includes placing biological materials in separate lysis vessels, adding lysis liquids to the biological materials in the lysis vessels, and transferring the liquids in the lysis vessels into a matrix unit. The liquids in the matrix vessels of the matrix unit are extracted through outlet openings during which the liquids flow through matrices and the matrix unit is placed on a collecting unit with collecting vessels which are arranged such that at least the outlet openings of the matrix vessels extend into the collecting vessels. The matrix vessels are with elution fluid and elution fluids from the matrix vessels are extracted through their outlet openings during which the elution fluids flow through the matrices and the elution fluids which are enriched with biological material are collected in the collecting vessels.Type: ApplicationFiled: October 27, 2003Publication date: May 13, 2004Inventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Thomas Walter
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Patent number: 6669910Abstract: System and process for isolating purified biological materials with a collecting unit which has collecting vessels that are accessible from above with a matrix unit in which matrix vessels are arranged in a holder as well as a closure unit which can be placed on the collecting unit to close the collecting vessel. In addition the invention also concerns a system having a collecting unit, a matrix unit, and a closure unit as well as a lysis unit and a waste unit. Moreover a new closure arrangement is disclosed which is suitable for closing vessels in which there is excess pressure.Type: GrantFiled: October 2, 2000Date of Patent: December 30, 2003Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Thomas Walter
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Patent number: 6258531Abstract: A method of isolating a biological material by a) providing a biological material which is bound to a porous matrix (C11), and b) compressing the matrix under conditions where the biological material is released from the surface of the matrix into an elution liquid. brings about the advantage that the emission of aerosols into the environment is greatly reduced. It is also possible to obtain highly concentrated and minute amounts of solution. The method is also easy to automate.Type: GrantFiled: March 26, 1996Date of Patent: July 10, 2001Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Michael Fritz, Jürgen Schwab, Edda Geisler, Herbert Harttig, Heinz Macho
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Patent number: 6117398Abstract: An instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.Type: GrantFiled: February 17, 1998Date of Patent: September 12, 2000Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Ulrich Schubert, Uwe Kolb, Burkhard Stolz, Manfred Pasch
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Patent number: 6017698Abstract: Subject matter of the invention is a method of binding a biological material to a solid phase by providing a sample liquid containing the biological material in a sample vessel (A) having an inner contour (A17); then a hollow body (C) which has a contour (C12) that matches the inner contour (A17) is introduced into the sample vessel (A) while being closed with respect to the sample vessel by means of a porous matrix (C11); the sample liquid can enter the structural form (C) through the porous matrix (C11). This method is easy to automate and reduces the generation of aerosols.Type: GrantFiled: April 1, 1996Date of Patent: January 25, 2000Assignee: Roche Diagnostics GmbHInventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Edda Geisler, Herbert Harttig, Heinz Macho
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Patent number: 5957822Abstract: A lid for closing an opening of a vessel includes a lid body configured to engage the opening, with the vessel having a defined shape. The lid body includes an engagement part which engages a corresponding surface of the vessel, thereby closing the opening. A handling element is disposed on an outer portion of the lid, with the handling element extending in parallel with an axis of the vessel. The handling element is for handling the lid for opening and closing the vessel.Type: GrantFiled: April 1, 1996Date of Patent: September 28, 1999Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Edda Geisler, Herbert Harttig, Heinz Macho
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Patent number: 5919622Abstract: A system for the temperature adjustment treatment of liquids, especially during the isolation and amplification of nucleic acids with a reusable thermostat element and a disposable heating element has the advantage of a particularly simple means of conducting temperature adjustment treatments. This system facilitates the execution of sample preparation and amplification in a single vessel.Type: GrantFiled: September 19, 1996Date of Patent: July 6, 1999Assignee: Boehringer Mannheim GmbHInventors: Heinz Macho, Gerhard Bienhaus
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Patent number: 5906947Abstract: A method for the repeated transfer of liquids from one of several storage containers into a transfer container wherein protective tips are placed onto a tip of a pipette in order to avoid contamination.Type: GrantFiled: December 22, 1997Date of Patent: May 25, 1999Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Hans Lange, Thomas Walter
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Patent number: 5855852Abstract: A vessel for reducing contamination of liquids is formed of a vessel body with an inlet opening and an outlet opening therein. A closing device is attached to the vessel body adjacent the outlet opening. The closing device closes the outlet opening, and includes a normally closed one-way valve which is openable by a predetermined pressure from within the vessel body.Type: GrantFiled: March 29, 1996Date of Patent: January 5, 1999Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Michael Fritz, Jurgen Schwab, Edda Geisler, Herbert Harttig, Heinz Macho
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Patent number: 5846489Abstract: System for the automatic operation of reactions using several vessels which can be closed by individual closures using a device for automatically opening the closures.Type: GrantFiled: April 11, 1997Date of Patent: December 8, 1998Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Hans Lange
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Patent number: 5837144Abstract: Method of separating a component of a liquid from other components by immobilizing the component to suspended magnetic particles in a vessel, immersing a magnetic device into the vessel while the device is separated from the liquid by means of a protective sleeve made of a non-magnetic material. Then the non-immobilized components are removed. The invention also addresses a device suitable for implementing this method. With said method and device, resuspension is achieved in a simple and efficient manner.Type: GrantFiled: June 15, 1995Date of Patent: November 17, 1998Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Burkhard Stolz, Ulrich Schubert
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Patent number: 5821436Abstract: A method for the repeated transfer of liquids from one of several storage containers into a transfer container wherein protective tips are placed onto a tip of a pipette in order to avoid contamination.Type: GrantFiled: June 12, 1995Date of Patent: October 13, 1998Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Hans Lange, Thomas Walter
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Patent number: 5746978Abstract: Device for the treatment of nucleic acids from the sample, comprising a first reaction chamber for separating the nucleic acids from other sample components, and a second reaction chamber for the amplification of the nucleic acids, connected to said first reaction chamber via a controllable transport path.Type: GrantFiled: July 17, 1997Date of Patent: May 5, 1998Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Hans Lange
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Patent number: 5576219Abstract: The present invention provides a process for the determination of the thyroxine-binding capacity in serum, wherein, for the calibration, there are used at least two different standard solutions which contain substantially the same amount of thyroxine-binding globulin but a differing content of thyroxine.The present invention also provides a standard solution for the determination of the thyroxine-binding capacity containing thyroxine-binding globulin dissolved in a buffer system.Type: GrantFiled: February 2, 1994Date of Patent: November 19, 1996Assignee: Boehringer Mannheim GmbHInventors: Gerhard Bienhaus, Helmut Jering
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Patent number: 5437981Abstract: Method for the immunological determination of a ligand in which the ligand to be determined is reacted witha) at least 2 molecules of a specifically bindable substance P2 of which at least one of these molecules carries a label andb) a receptor R which consists of a binding partner P1 which is capable of monovalent binding to P2 and a binding site R.sub.1 for the ligand to be determined and then the label is determined,as well as a reagent for the immunological determination of a ligand which contains a specifically bindable substance P2 which is present at least partially in labelled form and a receptor R which consists of a binding partner P1 which is capable of monovalent binding to P2 and a binding site R.sub.1 for the ligand to be determined.Type: GrantFiled: May 20, 1992Date of Patent: August 1, 1995Assignee: Boehringer Mannheim GmbHInventors: Arno Deger, Roland Schenk, Gerhard Bienhaus