Abstract: Novel derivatives of PF1022 substance, which are cyclodepsipeptides represented by the general formula (I) shown below or their salts are useful as anthelmintic agent for prevention or treatment of parasitic infections.

Abstract: The present invention relates to cyclic thiodepsipeptides, in particular 18 to 24-membered cyclothiodepsipeptides, their endoparasitical compositions, and methods of making and using the same.

Abstract: The present invention relates to a process for preparing ivermectin by selective hydrogenation of avermectin and subsequent removal of the catalyst.

Abstract: The present invention relates to a new process for the preparation of substituted aryllactic acid-containing cyclodepsipeptides having 24 ring atoms of the formula (I): ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 have the meaning given in the description,with the aid of fungal strains of the species Agonomycetales or enzymatic preparations isolated therefrom.

Abstract: The present invention relates to novel injection and infusion solutions of the following composition:a) 0.1 to 20% by weight of enrofloxacin, based on the total weight of the solution, in the form of its salts with polyhydroxycarboxylic acids or amino acids or mixtures thereof,b) polyhydroxycarboxylic acids, amino acids or mixtures thereof in 0.1 to 5 molar excess, based on enrofloxacin;c) optionally 0.1 to 30% by weight of formulation aids, based on the total weight of the solution;d) water to 100% by weight.

Abstract: The present invention relates to the use of cyclic depsipeptides having 18 ring atoms of the general formula (I) ##STR1## in which R.sup.1 to R.sup.6 have the meaning given in the description, and to their optical isomers and racemates, in medicine and veterinary medicine for combating endoparasites, to their preparation, and to new cyclic depsipeptides having 18 ring atoms.

Abstract: The invention relates to a process for the selective hydrogenation of avermectins with the aid of a rhodium-phosphine complex based on a hydrazine.

Abstract: New cyclic depsipeptides having 18 ring atoms, of the general formula (I) ##STR1## in which R represents hydrogen, straight-chain or branched or cyclic alkyl having up to 8 carbon atoms,and their optical isomers and racemates,and their use for combating endoparasites in the field of medicine and veterinary medicine.

Abstract: Substituted 1,3,4 -oxa- diazolinones of the formula (I) ##STR1## in which X represents O andY represents O or S,are disclosed as useful to combat endoparasites.

Abstract: Substituted 1,3,4-thiadiazolinones of the formula (I), ##STR1## in which X represents O or S,R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,R.sup.2 represents one or more identical or different radicals from the series comprising hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, each of which can, in turn, be substituted as well, andR.sup.3 represents alkyl, alkenyl or alkynyl, each of which can optionally be substituted,with the exception of the compound 5-methylmercapto-3-phenyl-1,3,4-thiadiazol-2-(3H)-one, are disclosed as being useful to combat endoparasites. Compositions containing these compounds, process for preparing them, and novel intermediates are also disclosed.

Abstract: Substituted 1,3,4-oxa- and thiadiazolinones of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,R.sup.2 represents one or more identical or different radicals from among hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be sutstituted,R.sup.3 represents one or more identical or different radicals from among hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.

Abstract: Novel 5-acyloxy-4(5H)-oxazolonium salts of the formula ##STR1## in which R.sup.1 represents an optionally substituted aliphatic group with up to 12 carbon atoms, an optionally substituted cycloalkyl group with 3 to 10 carbon atoms, an optionally substituted phenyl or naphthyl group or an optionally substituted heterocyclic group andR.sup.2 and R.sup.3 are identical or different and represent a hydrogen atom or an optionally substituted aliphatic group with up to 8 carbon atoms or an optionally substituted phenyl group andX.sup..crclbar. represents the anion of an inorganic or organic acid having a pK.sub.a value of less than 2,are obtained in solution when an acyl cyanide of the general formulaR.sup.1 --CO--N (II)is reacted with a carboxylic acid anhydride of the general formulaR.sup.2 --CO--O--CO--R.sup.3 (III)whereinR.sup.1, R.sup.2 and R.sup.3 each have the abovementioned meaning, in the presence of one or more inorganic or organic acids.

Abstract: Method of promoting the yield and growth of animals which comprises administering to such animals a yield and growth promoting effective amount of a benzimidazole derivative of the formula ##STR1## in which R.sup.1 stands for hydrogen, hydroxyl, alkyl or halogenoalkyl,R.sup.2 stands for hydrogen, alkyl, halogen, CN or halogenalkyl,R.sup.3 stands for hydrogen, alkyl or acyl,R.sup.4 stands for hydrogen, alkyl or halogenoalkyl,R.sup.5 stands for alkyl or halogenoalkyl,R.sup.6 stands for alkyl or cycloalkyl, which is optionally substituted by halogen, cycloalkyl, OH, alkoxy, halogenoalkoxy or aryl, which can in turn be substituted by alkyl, halogen, CN or the radicals --COR.sup.7, --O--alkylene--COR.sup.7, --alkylene--R.sup.8 or --O-- alkylene--R.sup.8,R.sup.7 stands for hydroxyl, alkoxy or --NR.sup.9 R.sup.10,R.sup.8 stands for hydroxyl, alkoxy or --NR.sup.9 R.sup.10,R.sup.9 stands for hydrogen or alkyl andR.sup.10 stands for hydrogen or alkyl,or physiologically tolerated salts thereof.

Abstract: Novel pesticidally active cyclic malonylphosphonic diamides of the formula ##STR1## in which X.sup. represents O or S,R.sup.1 represents alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heteroaryl, each of which can be optionally substituted,R.sup.2 represents hydrogen, alkyl, aryl or aralkyl,R.sup.3 represents hydrogen, alkyl, aryl or aralkyl, andR.sup.

Abstract: Novel 5-acyloxy-4(5H)-oxazolonium salts of the formula ##STR1## in which R.sup.1 represents an optionally substituted aliphatic group with up to 12 carbon atoms, an optionally substituted cycloalkyl group with 3 to 10 carbon atoms, an optionally substituted phenyl or naphthyl group or an optionally substituted heterocyclic group andR.sup.2 and R.sup.3 are identical or different and represent a hydrogen atom or an optionally substituted aliphatic group with up to 8 carbon atoms or an optionally substituted phenyl group andX.sup..crclbar. represents the anion of an inorganic or organic acid having a pK.sub.a value of less than 2,are obtained in solution when an acyl cyanide of the general formulaR.sup.1 --CO--CN (II)is reacted with a carboxylic acid anhydride of the general formulaR.sup.2 --CO--O--CO--R.sup.3 (III)whereinR.sup.1, R.sup.2 and R.sup.3 each have the abovementioned meaning,in the presence of one or more inorganic or organic acids having a pK.sub.

Abstract: A novel pest-combating agent of increased duration of action is produced by reacting a pest-combating agent having at least one hydrogen atom active in a Zerewitinoff reaction other than a hydrogen atom which is part of a carbamic acid ester group ##STR1## with a polyether isocyanate, the reaction with the polyether isocyanate taking place on said other hydrogen atom.

Abstract: A process for the preparation of a herbicidally active 1-amino-1,3,5-triazone-2,4 (1H,3H)-dione of the formula ##STR1## comprising in a first stage at a temperature from about 0.degree. to 100.degree. C. reacting an isocyanate of the formulaR.sup.1 - NCO (II)with an isothio semicarbazone of the tautomeric formulas ##STR2## in which R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, cycloalkyl, aralkyl o alkyl, cycloalkyl, aralkyl or aryl,thereby to form a urea derivative of the tautomeric formulas ##STR3## in a second stage at a temperature between about -50.degree. and 0.degree. C. reacting the urea derivative with phosgene (COCl.sub.

Abstract: Carboxylic acids and N-t.-alkylamines can be prepared simultaneously by the alkaline pressure hydrolysis of N-t.-alkyl carboxylic acid amides. A 5 to 50% strength by weight aqueous solution of an alkali metal hydroxide is employed for this purpose in an amount of 1.0 to 1.3 mols per mol of the amide. The process is carried out at 200.degree. to 350.degree. C.

Abstract: A new one-step process for the preparation of hydrazidines of the general formula ##STR1## in which R represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group or an optionally substituted aralkyl group,or their acid addition salts, in high yield comprises reacting iminoalkyl ethers of the general formula ##STR2## in which R has the abovementioned meaning andR.sup.1 represents an optionally substituted alkyl group or an optionally substituted cycloalkyl group,or their acid addition salts, with hydrazine in solvents under reduced pressure and at temperatures between -80.degree. and +100.degree. C., the reaction being effected in the presence of water present in the solvent and/or in the hydrazine by employing it as hydrazine hydrate. The hydrazidines of formula (I) and their salts are valuable intermediates in heterocyclic chemistry, for example for the synthesis of herbicidally active as-triazinones.