Abstract: The lozenge or chewable tablet contains, as the base, at least 30, preferably 50 to 70, percent by weight of an alkali metal and/or alkaline earth metal salt of at least one edible, organic acid, at least 10, preferably 20 to 40, percent by weight of a mixture of at least one unreacted, edible organic acid with at least one unreacted alkali metal or alkaline earth metal carbonate and/or bicarbonate and, if required, a pharmaceutical active substance and/or other conventional tablet assistants, such as flavors and sweeteners, disintegrants, hydrocolloids, etc.

Abstract: Granules, possibly pressed into the form of tablets, contain at least one insoluble, complexed or slightly soluble active substance in powder form which can bind or neutralize acids and which does not react with the acid of the effervescent system, and an effervescent system consisting of at least one organic, edible acid and at least one alkali metal and/or alkaline earth metal carbonate and/or bicarbonate. The active substance is present in an amount of 5 to 50, preferably 8 to 30, in particular 12 to 25%, by weight. It has an acid binding power of 2 to 40, preferably 3.5 to 25, meq/g, does not react with the acid of the effervescent system and increases the pH in 0.1N HCl during 2 min by a maximum of 0.5. It consists in particular of magnesium trisilicate, sucralfate and/or a bismuth salt. Each granule contains at least one acid component, at least one carbonate component and at least one active substance bound to one another.

Abstract: The surface of micronized and hydrophilized powder particles of a hydrophobic or sparingly soluble substance is covered with a cohesive layer of not more than 0.1 part by weight of surfactant in not more than 10 parts by weight of a binder (based on 100 parts by weight of the substance). A sparingly soluble or insoluble antibiotic is converted to instant granules or instant tablets, while a hydrophobic, moderately soluble to readily soluble pharmaceutical substance, such as, for example, acetylsalicylic acid or paracetamol, is converted to effervescent granules or effervescent tablets. The particles are preferably applied to carbohydrate crystals by means of a binder. The preparation is carried out by a method in which a solution which contains at least one surfactant in an amount of 0.01 to 0.

Abstract: An uncoated compressed tablet which is used for the preparation of an orally applicable aqueous suspension or solution of a pharmaceutically active substance contains a mixture of the pharmaceutically active substance, a swelling disintegrant and an effervescent system. The weight ratio of the disintegrant to the effervescent system is from 0.1:1 to 4:1.

Abstract: The present invention relates to the formation of an effervescent granulate which contains carnitine. The granulate is formed by combining an edible organic acid with an alkaline carbonate or an alkaline earth metal carbonate to form a preliminary reaction solution. After the addition of salt, the crystals are stirred and dried and then finally combined with carnitine.

Abstract: Solid, loose particulate materials are treated with vaporizable agent in a process chamber. The materials are combined with a mixture of hot gas and vapor in order to condense finely subdivided amounts of the treatment agent on the material. After a suitable time of reaction, the condensed material is partially removed from the treated material so that the pressure in the process chamber is reduced at least to the point at which the treatment agent partially evaporates, whereupon the portion which has revaporized is extracted from the process chamber. This cycle of introduction and removal of the treating agent is preferably repeated in a program-controlled operation until the desired result is achieved and a product which is suitably agglomerated is obtained.

Abstract: The invention relates to a pharmaceutical preparation that contains at least one pharmaceutically active substance at least one granular carrier material and a layer enveloping the carrier material that contains other components.

Abstract: Solid, loose particulate materials are treated with vaporizable agent in a process chamber. The materials are combined with a mixture of hot gas and vapor in order to condense finely subdivided amounts of the treatment agent on the material. After a suitable time of reaction, the condensed material is partially removed from the treated material so that the pressure in the process chamber is reduced at least to the point at which the treatment agent partially evaporates, whereupon the portion which has revaporized is extracted from the process chamber. This cycle of introduction and removal of the treating agent is preferably repeated in a program-controlled operation until the desired result is achieved and a product which is suitably agglomerated is obtained.

Abstract: Process for the preparation of an effervescent granular material containing at least one solid, crystalline, edible organic acid, particularly citric acid and at least one alkali metal or alkaline earth metal carbonate splitting off CO.sub.

Abstract: A desintegration tablet contains the filler material in a form and/or size which when coming in contact with water at ambient temperature dissolves so slowly that the water absorption and the action of the desintegration agent are not affected. The grains are either coated with a layer of slowly dissolving substance, in particular a colloid or pseudo-colloid, or consist of a crushed melted substance having a grain size preferably of between 0.2 and 0.6 mm, e.g. mannitol, sorbital and/or xylitol.

Abstract: A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.

Abstract: A chewing gum which consists of a chewing gum base, fats or waxes, fillers, additives and active substances, the chewing gum base being present in a particle size of 0.2 to 1 mm, together with the fillers, additives and active substances, in the matrix of fats and waxes. The tablet form is preferably coated with a tablet coating. Production is effected by separately comminuting the chewing gum base on the one hand and the matrix on the other hand at low temperatures, mixing the two types of granules and then pressing the mixture on a cooled tableting press. Finally, the tablets are coated with a covering layer and slowly heated to 40.degree.-45.degree. C.

Abstract: Effervescent granulates, particularly for the manufacture of effervescent tablets, comprising at least one solid, crystalline edible organic acid and at least one carbonate which releases carbon dioxide upon reaction with the organic acid, the acid crystals comprising a coating which contains calcium carbonate adhering to the surface of the acid crystals by means of a bonding layer formed by a reaction at the interface with the crystal of a calcium carbonate coating material. The coating is built up in multi-layers and includes at least two carbonate layers, the layer which is bonded essentially to the acid crystal being composed of calcium carbonate with the succeeding layers adhering to the carbonate layer by means of a bonding layer formed by reaction of the acid and the carbonate. The invention also deals with methods of manufacture as well as fields of use for the new effervescent granulates.

Abstract: The present invention is directed to a sifting device that is attached to a granulating apparatus. The sifting device includes a disk valve which can be shut, allowing the sifting device to be cleaned apart from the granulating apparatus, without detaching the sifting device from the granulating apparatus.

Abstract: The present invention is directed to a confectionery product, especially a chewing gum, having prolonged, extended delivery of flavoring, aroma, and/or active pharmaceutical ingredient. This is accomplished by providing the flavoring, aroma, or active pharmaceutical ingredient in a solid solution or mixture within a wax containing functional groups, said wax forming a homogeneous mixture or solid solution with a wax not containing any functional groups and substantially immiscible with the flavoring, aroma, or active pharmaceutical ingredient.

Abstract: The present invention is directed to an effervescent tablet for cleansing dental prostheses comprising an acidic component and an alkaline component, wherein one of said two components dissolves more slowly than the other component, with the more slowly dissolving component present in stoichiometric excess within the tablet, so that an initial acidic or alkaline pH is provided within the cleansing solution, with the pH gradually adjusting to the opposite alkaline or acidic region as the tablet effervesces.

Abstract: A cleaning pad comprises a porous flexible substrate impregnated with detergent, adhesive, a gas-generating compound and a compound to trigger release of gas by the gas-generating compound.

Abstract: A cleaning pad comprises a porous flexible substrate impregnated with detergent, adhesive, a gas-generating compound and a compound to trigger release of gas by the gas-generating compound.

Abstract: Apparatus for mixing and granulating a finely divided solid material, preferably including a screening of the final granular product, said apparatus including a mixing drum or cylindrical vessel with closable feed and discharge means, a rotatably driven shaft on the drum axis carrying conveyance means for mixing, stirring and conveying the solid material being treated, and pivotal support means to adjustably tilt the drum such that the drum axis and the rotatable shaft are pivoted within a substantially vertical plane. There is preferably a tubular discharge member at one end of the drum to provide a suitable sieve or screening means at the point where the final granular product is withdrawn from the drum. The apparatus is particularly useful in the mixing and granulation steps required to form a multi-component powdery material into granules which can be directly pressed and shaped into tablets, pellets, pills or the like.