Abstract: An apparatus is disclosed for filling a molded container and includes an inner filling tube provided with a valve member disposed for sliding engagement within the filling tube. A system is provided for supplying the filling tube with liquid product under pressure and includes a liquid product pressure vessel, a pump for supplying the pressure vessel with liquid product, pressurization means for pressurizing the pressure vessel with a gas such as air, nitrogen, or the like, associated interconnecting conduits, means for controlling the flow of the liquid product under pressure to the filling tube, and means for maintaining a desired amount of liquid product in the pressure vessel. A steam sterilization system and a system integrity testing means are also provided with the liquid product supply system.

Abstract: A method for the sterilization of a machine used in the formation, filling and sealing of plastic containers. A source of sterilizing agent, such as steam, is used to sterilize the various passageways, filters, and components within the machine which, if contaminated, would contaminate the liquid in the filled plastic container. Pressurized air or gas is delivered through sterilized lines having a micro-organism filter. The air flowing out of each filter is sterile and free from bacteria. A series of unique, easy to sterilize, three-position, two-way valves are used to duct pressurized gas and steam to the various components. A special air drop test apparatus is used to operationally check the integrity of the filters without breaching the sterile condition of the various fluid passageways and interconnected components.

Abstract: A blow-molded container is provided with an insert occluding its top opening. A closure structure at least partially encapsulates the insert article and includes a frangible web formed against the insert article. The container can be blow-molded in main mold halves and the closure structure, including the frangible web, can be formed by additional mold halves while the insert article is held in the container opening by an arm that is subsequently retracted or while the insert article is supported on a parison portion that defines the container body. In the latter instance a complete overcap for the insert article can be provided.

Abstract: A hermetically sealed container formed from thermoplastic material is provided with a hollow body having an open end terminating in a tapered wall defining a sealing region about an opening with a decreasing cross-sectional area in the direction toward the interior of the hollow body. A hollow plug insert is provided in the opening and has a peripheral sealing surface generally complementary with the defined sealing region. Over the opening is a closure structure that is unitary with the hollow body, that encloses the plug insert, and that retains the plug insert in the opening. A severable frangible web joins the closure structure to the hollow body outwardly of the opening.

Abstract: A method and apparatus are provided for molding a container such as an ampoule with a hermetically sealed top or closure joined to the upper portion of the container with a peripheral frangible web. Main mold halves defining a cavity are provided with an inwardly projecting portion that defines an upwardly facing bearing surface and a forming edge. A mandrel is provided with at least a downwardly facing first frustoconical sealing surface and with a frustoconical engaging surface extending downwardly and inwardly from the downwardly facing first frustoconical sealing surface. The mandrel is adapted to be positioned in a length of parison extending from the main mold means to temporarily seal the parison opening during vacuum or blow forming of the container.

Abstract: An overcap is provided for use with a hermetically sealed container which includes at least an external thread on a peripheral portion of the container, a cover portion closing the container, and a frangible web joining the cover portion to the container threaded portion. The overcap has a closed end, an open end, and at least a generally cylindrical inner peripheral portion oriented about a longitudinal axis with an internal thread on the interior of the overcap. A plurality of flexible fingers is provided on the interior of the overcap and project from the overcap between the overcap thread and the overcap closed end. Each finger projects inwardly toward the longitudinal axis and toward the closed end to accommodate the screwing of the overcap onto the container so that the overcap is operable upon rotation in the unscrewing direction to exert an axial force against the cover portion to fracture the frangible web for removal of the cover portion.

Abstract: A thermoplastic container is shown having an insert sealing the container. The insert includes a membrane which can be pierced to provide access to the inside of the container to draw off a substance such as a sterile liquid. The insert is held by a retaining structure which receives and seals with the insert.

Abstract: An improved apparatus is described for the sterilization of a machine used in the formation, filling and sealing of plastic containers. A source of sterilizing agent, such as steam, is used to sterilize the various passageways, filters, and components within the machine which, if contaminated, would contaminate the liquid in the filled plastic container. Pressurized air or gas is delivered through sterilized lines having a microorganism filter. The air flowing out of each filter is sterile and free from bacteria. A series of unique, easy to sterilize, three-position, two-way valves are used to duct pressurized gas and steam to the various components. A special air drop test apparatus is used to operationally check the integrity of the filters without breaching the sterile condition of the various fluid passageways and interconnected components.

Abstract: A container which includes body, neck and cover portions of one-piece plastic construction and a line of weakness defined between the neck and cover portions to permit selective separation of the cover from the neck, further includes an inner closure carried by and removable with the cover portion to prevent spillage of the container contents upon opening of the container. The inner closure is disposed to seal the neck below the line of weakness to isolate the contents of the container from the area of the line of weakness. When the container is heat sterilized, means is provided associated with the chamber defined by the cover and closure to prevent collapse of the cover during the post heat-sterilization cooling cycle. The associated means includes structure to provide moist air in the defined chamber during heating of the container without endangering the sterility of the container contents or nullifying the advantage of the inner closure.

Abstract: A cap threadedly receivable on a severable cover of a hermetically sealed container is provided. The cap has a reduced surface area for engaging an annular bearing surface of the container. Screwing the cap further down onto the container transmits oppositely directed forces to the container body and to the container cover, thereby severing the cover from the body.

Abstract: A method for forming a unitary, hermetically sealed dispensing container wherein a first mandrel is provided to blow-mold the container and wherein a second mandrel is provided for subsequently filling the formed container.

Abstract: An apparatus for the sterilization of a machine used in the formation, filling and sealing of plastic containers. A source of sterilizing agent, such as steam, is used to sterilize the various passageways, filters, and components within the machine which, if contaminated, would contaminate the liquid in the filled plastic container. Pressurized air or gas is delivered through sterilized lines having a microorganism filter. The air flowing out of each filter is sterile and free from bacteria. A series of unique, easy to sterilize, three-position, two-way valves are used to duct pressurized gas and steam to the various components. A special air drop test apparatus is used to operationally check the integrity of the filters without breaching the sterile condition of the various fluid passageways and interconnected components.

Abstract: A unitary, hermetically-sealed dispensing container, having plural removable closures and suitable for containing and dispensing sterile solutions, is provided. The removable closures are unitary with the container. The dispensing container comprises a sealed, elongated shell of thermoplastic material provided with at least one access port at each end of the shell, a neck portion unitary with the shell and surrounding each access port, and removable cap means over the access ports and joined to the corresponding neck portions by means of frangible annular webs. The frangible annular webs are unitary with the cap means and with the neck portions. At least one of the neck portions is provided with a bore of predetermined controlled dimensions and is adapted to receive a draining spike or a similar means for withdrawing the contents of the container.

Abstract: A hermetically sealed container is provided with a neck portion having an end wall defining a container contents-dispensing aperture therein. The aperture is closed with a removable cap structure connected with a frangible web unitary with the end wall and cap so as to seal the container contents-dispensing aperture. An overcap is rotatably mounted on the container and has a cage for matingly engaging the cap and is adapted to break the frangible web when the overcap is rotated.

Abstract: A unitary, hermetically-sealed dispensing container, having plural removable closures and suitable for containing and dispensing sterile solutions, is provided. The removable closures are unitary with the container. The dispensing container comprises a sealed, elongated shell of thermoplastic material provided with at least one access port at each end of the shell, a neck portion unitary with the shell and surrounding each access port, and removable cap means over the access ports and joined to the corresponding neck portions by means of frangible annular webs. The frangible annular webs are unitary with the cap means and with the neck portions. At least one of the neck portions is provided with a bore of predetermined controlled dimensions and is adapted to receive a draining spike or a similar means for withdrawing the contents of the container.

Abstract: A stopper is provided which is adapted to be held in place in an opening in a molded thermoplastic container that is molded about the stopper in place. The stopper has a substantially cylindrical body portion with a planar end surface at one end thereof and a unitary skirt portion depending from the other end of the body portion. An annular flange, unitary with the body portion, extends laterally away from the body portion in one end thereof to define first and second peripheral flange surfaces and a lateral flange surface. The first peripheral flange surface is contiguous with the planar end surface and with the lateral flange surface. The first peripheral flange surface further is disposed at an angle with respect to the planar end surface and converges towards the second peripheral flange surface in a direction away from the body portion. The second peripheral flange surface is contiguous with the lateral flange surface and the skirt portion.

Abstract: A hermetically sealed container with plural access ports is provided. The closure includes a severable dome unitary with the container and positioned over the container access opening. The dome is severable from the container by the action of a collar threadedly attached to the container. The dome is further provided with an access aperture that is closed off by a twist-off cap which, upon removal, exposes the dispensing aperture.

Abstract: A unitary, hermetically-sealed but pierceable dispensing container, suitable for packaging parenteral solutions, is made from a flexible, generally tubular body of thermoplastic material utilizing a form, fill and seal technique and a movable, composite mandrel that includes a forming ram member for compression molding from within the container a container wall portion which includes a pierceable membrane. The tubular body is closed at one end and terminates at the other end in a draining region having an access aperture or port sealed by a unitary membrane of predetermined thickness. The membrane permits penetration of a cannula therethrough without coring, and an annular sealing means surrounding the aperture is adapted for frictional and sealing engagement of the cannula after the membrane has been penetrated.

Abstract: A unitary, hermetically sealed but pierceable dispensing container, suitable for packaging parenteral solutions, is made from a flexible, generally tubular body of thermoplastic material utilizing a form, fill and seal technique and a movable, composite mandrel that includes a forming ram member for compression molding from within the container a container wall portion which includes a pierceable membrane. The tubular body is closed at one end and terminates at the other end in a draining region having an access aperture or port sealed by a unitary membrane of predetermined thickness. The membrane permits penetration of a cannula therethrough without coring, and an annular sealing means surrounding the aperture is adapted for frictional and sealing engagement of the cannula after the membrane has been penetrated.