Abstract: The invention relates to a novel pharmaceutical preparation which can be administered nasally and is based on an aqueous solution, emulsion or the like which comprises at least one mucosally absorbable and/or locally acting active pharmaceutical ingredient, at least one preservative formed by benzalkonium chloride alone or together with other preservative substances, at least one buffer which keeps the pH at 4 to 6, and in addition at least one osmotic agent and/or at least one wetting agent and which is characterized in that the preparation has a substantially improved ciliary tolerability owing to the fact that in the preparation a buffer based on malic acid is present instead of a buffer which has been employed to date in the pharmaceutical preparation and is based on citrate(s), phosphate(s) and/or acetate(s)—partly or completely replacing it (them)—while retaining the composition, concentration and amount ratios, intended in each case for the pharmaceutical preparation, of active ingredient(s), preservat

Abstract: A stable, nasally, orally or sublingually applicable pharmaceutical preparation for administering to patients has an aqueous solution of desmopressin as the active agent. Said solution contains an osmoticum and a buffer which maintains the pH-value in the range of 4 to 6, preferably about 5. The buffer is malic acid, preferably in the form of a racemate. Thereby an improved stability of the desmopressin content in the preparation is obtained.

Abstract: A topically applicable pharmaceutical composition comprises at least one liquid lipid, at least one pharmaceutical active ingredient which is soluble in at least one of the liquid lipids and is re-absorbed by the skin, and a hydrous gel which is the main component of the composition, whereby at least one lipid and at least one active ingredient are worked into the gel and the composition is essentially free of emulsifying agents and solid constituents, with the exception of the necessary gelatinizing agent required to form the hydrous gel. All of the active ingredients are present in dissolved form, whereby at least one active ingredient is dissolved in the liquid lipid, and this lipid containing the dissolved active ingredient is itself the internal phase and is worked into the hydrous gel as the external phase. The composition is also essentially free of surface-active substances.

Abstract: A process for the production of S(+)-ibuprofen-particles having improved flow properties comprises the steps that coarse-crystalline S(+)-ibuprofen is molten and then in a molten condition is finely distributed in a non-solving medium, preferably in cold water, and is chilled therein. This chilling results in a fine-crystalline primary structure that agglomerates to a secondary structure. In this agglomerate form the product is obtained which is filtered out and is dried. Such particles are suitable for direct pressing of tablets, optionally, tableting auxiliary substances being added, also for the production of tablets having a retarded release of the active substance.

Abstract: Stabilization method for 4-methyl-5-(2'-chloroethyl)-thiazol, where the latter is mixed with a nontoxic carrier substance which contains at least one triglyceride of at least one saturated fatty acid with a chain length of C.sub.8 to C.sub.12, preferably an oil.