Abstract: A method for determining a flow rate and/or a flow velocity of a medium interacting with at least a first and a second temperature sensor element and a heating element, wherein the method comprises the following method steps: heating the medium by means of the heating element for a predetermined heating duration, wherein the medium before the heating is largely in thermal equilibrium with at least the first and second temperature sensor elements; registering at least a first and a second measured value with the assistance of the first temperature sensor element and at least a third and a fourth measured value with the assistance of the second temperature sensor element for characterizing first and second temperature rises of the medium; and ascertaining the flow rate and/or flow velocity of the medium based on the at least two temperature rises.

Abstract: A method for determining a flow rate and/or a flow velocity of a medium interacting with at least a first and a second temperature sensor element and a heating element, wherein the method comprises the following method steps: heating the medium by means of the heating element for a predetermined heating duration, wherein the medium before the heating is largely in thermal equilibrium with at least the first and second temperature sensor elements; registering at least a first and a second measured value with the assistance of the first temperature sensor element and at least a third and a fourth measured value with the assistance of the second temperature sensor element for characterizing first and second temperature rises of the medium; and ascertaining the flow rate and/or flow velocity of the medium based on the at least two temperature rises.

Abstract: A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue comprises a microdialysis probe comprising a microdialysis membrane, the probe being adapted to be placed in blood or in tissue, a flow through sensor for analyzing a fluid having passed the microdialysis probe, a pump for pumping the fluid to and through the microdialysis probe and further to and through the sensor, and tubing connecting the pump to the microdialysis probe and the microdialysis probe to the sensor. The pump effects a flow rate in the system in the interval 0.2-15 microliters per minute. The sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra filtering in the microdialysis membrane.

Abstract: A measuring system (100) for continuously measuring body fluid constituents, said measuring system (100) comprising a microdialysis catheter or probe (110) comprising a microdialysis membrane (116) to be placed in a blood stream or in tissue fluid. The measuring system further comprises a flow through sensor (200) for continuously measuring the concentration of substances present in the fluid that has passed the microdialysis membrane (116). The measuring system (100) further comprises a waste container (126).

Abstract: A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue comprises a microdialysis probe comprising a microdialysis membrane, the probe being adapted to be placed in blood or in tissue, a flow through sensor for analysing a fluid having passed the microdialysis probe, a pump for pumping the fluid to and through the microdialysis probe and further to and through the sensor, and tubing connecting the pump to the microdialysis probe and the microdialysis probe to the sensor. The pump effects a flow rate in the system in the interval 0.2-15 microliters per minute. The sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra filtering in the microdialysis membrane.

Abstract: A sensor for continuous detection of one or more analytes in a liquid flow, comprising an array of electrodes together forming an essentially planar sensing surface and a flow distributor with a flow inlet a flow channel and a flow outlet in order to establish a liquid flow of analytes along the sensing surface. The flow inlet and the flow outlet are located in a plane different to the plane of the sensing surface. The array of electrodes is arranged so that, in the direction from the flow inlet to the flow outlet, the array of electrodes consecutively comprises a first blank electrode, at least one measuring electrode, a second blank electrode, at least one measuring electrode and optionally a third blank electrode.

Abstract: A measuring system (100) for continuously measuring body fluid constituents, said measuring system (100) comprising a microdialysis catheter or probe (110) comprising a microdialysis membrane (116) to be placed in a blood stream or in tissue fluid. The measuring system further comprises a flow through sensor (200) for continuously measuring the concentration of substances present in the fluid that has passed the microdialysis membrane (116). The measuring system (100) further comprises a waste container (126).

Abstract: The present invention relates to a device for performing immuno assays (“biochip” or “lab on chip” respectively), a procedure for its fabrication and the use of the device for performing immuno assays. Furthermore the present invention relates to the use of a photo lithographically patternable dry film photo resist based on a material with functional chemical groups for the immobilization of biomolecules.

Abstract: A reagent matrix composition disposed on an electrically conductive electrode to form an in-vivo sensor for a predefined analyte includes a first hydrogel layer containing an enzyme that is a substrate for the analyte adjacent the electrically conductive electrode and a composite membrane layer disposed onto the first hydrogel layer where the composite layer includes a membrane hydrogel containing a plurality of microspheres. The plurality of microspheres is made of a material having no or little permeability to the analyte and a substantially high permeability to oxygen.

Abstract: An in-vivo sensor assembly includes an assembly body having a body proximal end and a body distal end, a plurality of sensor elements including at least an analyte sensor element containing an enzyme that is a substrate of the analyte to be measured, a reference sensor element and a temperature sensor element disposed at or near the body distal end wherein the at least an analyte sensor element and the reference sensor element are exposed to the sample fluid and the temperature sensor is capable of measuring the temperature of and adjacent to the analyte sensor element, and an electrical coupling means disposed at the body proximal end and configured to couple to the at least an analytical sensor element, the reference sensor element and the temperature sensor element.

Abstract: The present invention relates to a device for performing immuno assays (“biochip” or “lab on chip” respectively), a procedure for its fabrication and the use of the device for performing immuno assays. Furthermore the present invention relates to the use of a photo lithographically patternable dry film photo resist based on a material with functional chemical groups for the immobilization of biomolecules.

Abstract: Sensors that are capable measuring the rate of flow of a fluid that passes over the electrodes of the sensor. In these sensors, an electrode, designated the flow rate-determining electrode, is used in conjunction with the conventional electrodes, e.g., the working electrode, the reference electrode, and the counter electrode, to determine the rate of flow of the fluid. In one aspect, this invention provides a sensor for measuring the concentration of an analyte in a sample of fluid when the sample flows continuously over the electrodes of the sensor, especially when the rate of flow of the sample is relatively low. In another aspect, this invention provides a method for measuring the concentration of an analyte in a sample of fluid, wherein the rate of flow of the sample varies during the period of time that the sensor is in place. In a preferred embodiment, the sensor employs four electrodes, namely, a working electrode, a reference electrode, a counter electrode, and a flow rate-determining electrode.

Abstract: Sensors that are capable measuring the rate of flow of a fluid that passes over the electrodes of the sensor. In these sensors, an electrode, designated the flow rate-determining electrode, is used in conjunction with the conventional electrodes, e.g., the working electrode, the reference electrode, and the counter electrode, to determine the rate of flow of the fluid. In one aspect, this invention provides a sensor for measuring the concentration of an analyte in a sample of fluid when the sample flows continuously over the electrodes of the sensor, especially when the rate of flow of the sample is relatively low. In another aspect, this invention provides a method for measuring the concentration of an analyte in a sample of fluid, wherein the rate of flow of the sample varies during the period of time that the sensor is in place. In a preferred embodiment, the sensor employs four electrodes, namely, a working electrode, a reference electrode, a counter electrode, and a flow rate-determining electrode.