Abstract: The method of making borosilicate glass with a surface having reactive SiOH groups on it includes preparing a borosilicate glass melt and dissolving at least 30 mMol per liter of water in the borosilicate glass melt. The borosilicate glass contains from 70 to 87 percent by weight, SiO2; from 7 to 15 percent by weight, B2O3; from 0 to 8 percent by weight, Al2O3; from 0 to 8 percent by weight, Na2O and from 0 to 8 percent by weight of K2O. The borosilicate glass with the easily modified reactive surface can be used as a substrate for chemically covalent immobilization of reactive substances. This substrate can be used to make a biochemical chip, such as a DNA or gene chip, or dirt-proof window glass.

Abstract: The invention relates to a method for the production of borosilicate glass with a surface which can be easily modified, having reactive SiOH-groups. According to said method, a glass melt is produced wherein water is dissolved in quantities of at least 30 mMol of water per litre. Said glass is especially suitable for use as a substrate for sensors and biochips, dirt-proof working glass for windows, reagent glass, laboratory glass, microarrays, electronic noses, artificial nose chips, electronic tongues, chips for the polymerase-chain reaction, DNA-microarray chips, gene chips, protein chips, in addition to biochemical laboratories on a chip.