Patents by Inventor Gerhard Penn

Gerhard Penn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10851059
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: December 1, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Ives Mafli, Benjamin Martin, Gerhard Penn, Gottfried Sedelmeier, Joerg Sedelmeier, Francesco Venturoni
  • Publication number: 20190308927
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
  • Patent number: 10377697
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 13, 2019
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • Publication number: 20190202785
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Application
    Filed: August 16, 2017
    Publication date: July 4, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Ives MAFLI, Benjamin MARTIN, Gerhard PENN, Gottfried SEDELMEIER, Joerg SEDELMEIER, Francesco VENTURONI
  • Publication number: 20180354889
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 13, 2018
    Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
  • Publication number: 20120220775
    Abstract: A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II wherein M, L, X, R1, R2 and R3 have the meanings as indicated in the specification.
    Type: Application
    Filed: May 1, 2012
    Publication date: August 30, 2012
    Inventors: Olivier Lohse, Caspar Vogel, Gerhard Penn
  • Patent number: 8084487
    Abstract: The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: December 27, 2011
    Assignee: Novartis AG
    Inventors: Ernst Kuesters, Murat Acemoglu, Philipp Lustenberger, Gottfried Sedelmeier, Beat Schmitz, Gerhard Penn
  • Patent number: 7985323
    Abstract: Purification process for the preparation of the allylamine pharmaceutical terbinafine of formula I in free base form or acid addition salt form, by distilling crude terbinafine base, preferably by short path distillation, e.g. at a temperature above 100° C. and reduced pressure, e.g. 0.2 mbar, and recovering the purified product in free base or acid addition salt form.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: July 26, 2011
    Assignee: Novartis AG
    Inventors: Ulrich Beutler, Gerhard Penn
  • Publication number: 20110144352
    Abstract: The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers.
    Type: Application
    Filed: August 10, 2009
    Publication date: June 16, 2011
    Applicant: NOVARTIS AG
    Inventors: Ernst Kuesters, Murat Acemoglu, Philipp Lustenberger, Gottfried Sedelmeier, Beat Schmitz, Gerhard Penn
  • Publication number: 20100087545
    Abstract: Process for the preparation of pure allylamine pharmaceutical terbinafine of formula I in free base form or acid addition salt form, by distilling crude terbinafine base, preferably by short path distillation, e.g. at a temperature above 100° C. and reduced pressure, e.g. 0.2 mbar, and recovering the purified product in free base or acid addition salt form. The process is indicated for use in removal of metal or non-metal contaminants, optionally together with salt formation under simultaneous precipitation of pure trans isomer. Detection of non-metal contaminants such as substance A of formula preferably is effected by RP HPLC analysis with UV detection.
    Type: Application
    Filed: January 16, 2009
    Publication date: April 8, 2010
    Inventors: Ulrich Beutler, Peter Funfschilling, Gerhard Penn, Alfons Roth
  • Patent number: 7605267
    Abstract: The invention relates to a process for preparing 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-ones.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: October 20, 2009
    Assignee: Novartis AG
    Inventors: Olivier Lohse, Gerhard Penn, Hanspeter Schilling
  • Publication number: 20090216047
    Abstract: Purification process for the preparation of the allylamine pharmaceutical terbinafine of formula I in free base form or acid addition salt form, by distilling crude terbinafine base, preferably by short path distillation, e.g. at a temperature above 100° C. and reduced pressure, e.g. 0.2 mbar, and recovering the purified product in free base or acid addition salt form.
    Type: Application
    Filed: November 14, 2008
    Publication date: August 27, 2009
    Inventors: Ulrich Beutler, Gerhard Penn
  • Publication number: 20090054653
    Abstract: A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II wherein M, L, X, R1, R2 and R3 have the meanings as indicated in the specification.
    Type: Application
    Filed: June 21, 2005
    Publication date: February 26, 2009
    Inventors: Olivier Lohse, Caspar Vogel, Gerhard Penn
  • Publication number: 20060189653
    Abstract: The invention relates to a process for preparing 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-ones.
    Type: Application
    Filed: April 1, 2004
    Publication date: August 24, 2006
    Inventors: Olivier Lohse, Gerhard Penn, Hanspeter Schilling
  • Publication number: 20060076227
    Abstract: Purification process for the preparation of the allylamine pharmaceutical terbinafine of formula I in free base form or acid addition salt form, by distilling crude terbinafine base, preferably by short path distillation, e.g. at a temperature above 100° C. and reduced pressure, e.g. 0.2 mbar, and recovering the purified product in free base or acid addition salt form.
    Type: Application
    Filed: August 27, 2004
    Publication date: April 13, 2006
    Inventors: Ulrich Beutler, Gerhard Penn
  • Publication number: 20050197512
    Abstract: Process for the preparation of pure allylamine pharmaceutical terbinafine of formula I in free base form or acid addition salt form, by distilling crude terbinafine base, preferably by short path distillation, e.g. at a temperature above 100° C. and reduced pressure, e.g. 0.2 mbar, and recovering the purified product in free base or acid addition salt form. The process is indicated for use in removal of metal or non-metal contaminants, optionally together with salt formation under simultaneous precipitation of pure trans isomer. Detection of non-metal contaminants such as substance A of formula preferably is effected by RP HPLC analysis with UV detection.
    Type: Application
    Filed: March 8, 2005
    Publication date: September 8, 2005
    Inventors: Ulrich Beutler, Peter Funfschilling, Gerhard Penn, Alfons Roth
  • Patent number: 6706727
    Abstract: The composition of formula I wherein the substituents have various significances, whereby one of R2 to R4 is ethyl. They can be prepared by fermentation, or by replacement of hydroxy with chloro under simultaneous or concomitant epimerization. They are indicated for use as pharmaceuticals in the prevention or treatment of inflammatory conditions and of conditions requiring immunosuppression, optionally in combination or association with further pharmaceutically active and compatible agents, e.g. macrolactam macrolides such as pimecrolimus.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: March 16, 2004
    Assignee: Novartis AG
    Inventors: Gerhard Fleissner, Helmut Häcker, Ernst Küsters, Gerhard Penn
  • Patent number: 6423722
    Abstract: 33-Epichloro-33-desoxyascomycin of formula I and various tautomeric or forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula I, or compound of formula I in other than Form A, or compound of formula I in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively. Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: July 23, 2002
    Assignee: Novartis AG
    Inventors: Cornelia Dosenbach, Maximilian Grassberger, Otto Hartmann, Amarylla Horvath, Jean-Paul Mutz, Gerhard Penn, Sabine Pfeffer, Dierk Wieckhusen