Abstract: The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.

Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.

Abstract: On reaching an approach area to a destination airport, the aircraft is provided with up-to-date topographical information and route information in addition to a destination position on the ground. Wireless communication technologies, such as GSM, GPRS, UMTS, WLan, WiMax, and the like are used to transmit this information. Advantageously, the transmitted information can be displayed on a commercially available navigation system on board the aircraft and can be used for navigation on the ground.

Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.

Abstract: The present invention relates to a pharmaceutical formulation for oral administration of the poorly soluble and therefore hardly bioavailable microtubule polymerization inhibitor Indibulin and a process for its manufacture. In particular, there is provided a pharmaceutical formulation of Indibulin for oral administration comprising a granulate containing micronized Indibulin having a particle size of less than 20 ?m for at least 99% of the volume of particles, at least one hydrophilic surfactant, and at least one capsulation excipient. The present invention also discloses a method of treating hyperproliferative disorders, malignancies and neoplasms with Indibulin.

Abstract: The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.

Abstract: A capacitance diode has a substrate of a first conductivity type, an epitaxial layer of the first conductivity type present thereon, a first zone of the first conductivity type diffused therein and a second surface zone of the second opposite conductivity type over said first zone and forming a p-n junction with the first zone. According to the invention, the doping profile in the first zone varies substantially according to the equation N(x)=N.sub.o e.sup.-.beta.x +N.sub.E, where N.sub.o is the doping concentration of the first zone at the p-n junction, N is the doping concentration of the epitaxial layer, and x is the distance from the p-n junction, and where N.sub.o <24 N.sub.E. As a result, a small frequency deviation is obtained, and this frequency deviation does not change sign.

Abstract: A photosensitive semiconductor resistor has a monocrystalline semiconductor body of one conductivity type which, on two oppositely located surfaces, is provided with an anode contact and with a cathode contact, and is constructed so that the cathode contact is a highly doped zone of the same conductivity type as the semiconductor body. The semiconductor body can be exposed to photon radiation at its surface supporting the cathode contact and the area of the anode contact is at least 1000 times larger than the area of the cathode contact. Such a photosensitive semiconductor resistor is easy to manufacture and has both a low inertia and a good sensitivity.

Abstract: A capacitance diode includes an epitaxial layer of a first conductivity type provided on a substrate in which a doping profile is formed in the epitaxial layer by controlled doping during the epitaxial layer growth, and a surface zone of the second conductivity type which forms a p-n junction with the epitaxial layer. According to the invention, the doping profile in the epitaxial layer varies according to the equation ##EQU1## wherein x is the distance from the p-n junction in .mu.m, x.sub.o is the width of the barrier layer in .mu.m at a voltage -U.sub.D across the p-n junction, U.sub.D is the diffusion voltage of the p-n junction, and k, n and .beta. are constants. As a result of this doping profile, a very low frequency deviation is obtained which does not change sign.