Abstract: A method and apparatus for influencing a biological material, both being intended to influence such characteristics are correlated with the occurrence of natural atmospherics, i.e., the proliferation rate of C6-glioma cells and the survival time of Yoshida-ascites-hepatoma rats. For this purpose, signals representing the time history of the magnetic field of certain natural atmospherics are stored, which are identified by means of distinctly pronounced frequency fractions, e.g., 10 kHz. Using these signals, corresponding magnetic field variations are reproduced as artificial atmospherics. Reproduction is effected, e.g., in a Helmholtz coil. The biological material is exposed to this magnetic field.

Abstract: A process for determining the pH value in the interior of a cell is descrd. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.

Abstract: A method for alerting patients with diseases affected by climate, such as epilepsy and myocordial infarction, according to which sinusoidal spheric pulses having a frequency of 28 kHz and sinusoidal spheric pulses having a frequency of 10 kHz are measured by a spheric selector circuit. The pulse rate of these spheric pulses is ascertained over a predetermined period of time and the difference between the pulse rates of the spheric pulses at 28 kHz and those at 10 kHz is ascertained. If the spheric pulses having a frequency of 28 kHz predominate, then the patient is alerted by means of a signal generated by a circuit which includes the spheric selector circuit for carrying out the method.

Abstract: A process for determining the pH value in the interior of a cell is described. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.

Abstract: A process for determining the pH value in the interior of a cell is described. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.

Abstract: A process for making factor for stimulating the rate of proliferation of liver cells comprising homogenizing animal Peyer's glands, adjusting pH to about 5.5, thermally denaturing the product and recovering the desired factor in the supernatant by centrifugation.

Abstract: A factor which causes an increase in the number of liver cells through increased cell division activity, obtained by homogenizing the remaining livers of partially hepatectomized animals, subjecting the homogenate to acidification to pH=5.5 and then heat treatment at 95.degree. C., and centrifuging said homogenate. After such treatment, the factor is contained in the supernatant. The factor is a neuraminic-acid-free protein with a molecular weight of approximately 30,000 to 50,000 D. An extract containing the factor also can be obtained from the blood plasma of hepatectomized animals, when the plasma in addition to the described steps further is treated with neuraminidase. Similarly, an extract containing the factor can be obtained from the livers or the plasma of non-hepatectomized fetal or very young animals.

Abstract: A drug for stimulating the rate of proliferation of liver cells having as s active ingredient a blood plasma extract (NP) and a method of preparing such a drug wherein blood plasma is first acidified to a pH of 5.5, then heat denatured at approximately 95.degree. C. and subsequently centrifuged to provide the extract.

Abstract: The increase in concentration of one or several plasma-proteins in the blood is specific for various pathological processes, especially inflammations. A medicament which in a typical way, exactly contains increasingly available plasma-proteins for a pathological process, attenuates the progress of the pathological process, as by this means, the defence system of the body itself is strengthened, which reacts in a specific way on such pathological processes, with the increased formation of one or several plasma-proteins specific for this. This effect is especially demonstrated in regard to Fibrinogen. It demonstrates further that the effect of the Fibrinogen is thereupon to be traced back in that, in regard to reaction with Thrombin at the point of the inflammation, the fibrinopeptides A and B are formed.

Abstract: A method for simultaneous qualitative and quantitative analysis of antigens r antigen-effective substances in a sample provides placing the sample in a carrier medium through which it migrates toward a plurality of physically separate carrier strips. The medium on each strip contains a quantity of a specific ingredient, for example an antibody, which is expected to undergo a specific immunoreaction with one of the constituents in the sample, thereby producing a visible precipitate. The dimensions of the final precipitate then permit a direct measurement of the identified substance. A known concentration of a calibrating substance may be added to the sample to provide for calibration precipitates in the various strips. The apparatus for practicing the method includes a base plate on which the neutral, antibody-free carrier medium as well as the various strips containing media with antibodies or other immunoreactive ingredients are located.

Abstract: A method for simultaneous qualitative and quantitative analysis of antigens r antigen-effective substances in a sample provides placing the sample in a carrier medium through which it migrates toward a plurality of physically separate carrier strips. The medium on each strip contains a quantity of a specific ingredient, for example an antibody, which is expected to undergo a specific immunoreaction with one of the constituents in the sample, thereby producing a visible precipitate. The dimensions of the final precipitate then permit a direct measurement of the identified substance. A known concentration of a calibrating substance may be added to the sample to provide for calibration precipitates in the various strips. The apparatus for practicing the method includes a base plate on which the neutral, antibody-free carrier medium as well as the various strips containing media with antibodies or other immunoreactive ingredients are located.