Patents by Inventor Gerhard Stocklin

Gerhard Stocklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of .sup.18 F-labeled organic compounds by nucleophilic substitution
    Patent number: 4794178
    Abstract: Organic compounds labeled with no-carrier-added fluorine 18 are processed yield a compound having a formula in the form of .sup.18 F-R through a nucleophilic substitution reaction. The process has a series of steps. The first step of the process relates to providing an organic compound having a formula of X-R. X is the nucleophilic leaving group in the substitution action, and R is a preferred substituted hydrocarbon structure being selected from aliphatic, alicyclic, heterocyclic aliphatic, carbocyclic and heterocyclic aromatic structures. The X-R compounds with acid hydrogen are excluded. The next step is to bring the organic compound X-R into contact with fluoride ions which are present in a solvent. These fluoride ions are essentially carrier free .sup.18 F ions. The organic compound is brought into contact with the fluoride ions in an apparatus to produce a reaction.
    Type: Grant
    Filed: July 5, 1985
    Date of Patent: December 27, 1988
    Assignee: Kernforschungsanlage Julich Gesellschaft mit beschrankter Haftung
    Inventors: Heinrich H. Coenen, Kurt Hamacher, Manfred Schuller, Gerhard Stocklin, Bernd Klatte, Arndt Knochel
  • Labeled fatty acids and method of making and using same
    Patent number: 4323547
    Abstract: Radioactive-halogen labeled fatty acids, especially fatty acids having as an .omega.-terminal or mid-chain substituent 18.sub.F as the labeling atom. The hydrocarbon has more than fifteen carbon atoms in the hydrocarbon chain and is purified by high pressure liquid chromatography for use in investigating the kinetics of material exchange in the heart muscle.
    Type: Grant
    Filed: June 28, 1979
    Date of Patent: April 6, 1982
    Assignee: Kernforschungsanlage Julich GmbH
    Inventors: Ernst J. Knust, Christiane Kupfernagel, Gerhard Stocklin
  • Method of making 1.sup.123 labeled fatty acids
    Patent number: 4290965
    Abstract: A procedure for making .omega.-I.sup.123 labeled fatty acids in which the .omega.-bromo-fatty acid is applied in a thin film or layer to a support and is there contacted in molten state with the I.sup.123 iodide to effect halogen exchange.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: September 22, 1981
    Assignee: Kernforschungsanlage Julich, Gesellschaft mit beschrankter Haftung
    Inventors: Gerhard Stocklin, Peter Laufer, Jurgen Machulla