Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: A method and an apparatus for testing the adhesive strength of overlays attached to the inside of plain bearing bushings. The method is characterized in specifying clearance between the plain bearing bushing tested and a rotating or oscillating pin extending through the bushing. Next, feeding a liquid medium into the gap between the bushing and the pin and oscillating the plain bearing bushing and pin relative to one another perpendicularly to the bushing axis for a given period and examining the bushing after the load test. The corresponding apparatus comprises a pin mounted rotatably in a pin receptacle and on which there is arranged a first drive mechanism. In addition, a bushing receptacle is provided, in which the plain bearing bushing is fitted, wherein the pin is mounted with predetermined clearance in the bushing. The apparatus additionally comprises a mechanism for bringing about oscillating relative movement of bushing receptacle and pin receptacle.

Abstract: The invention relates to gudgeon pin bushes which find application in highly-stressed engines, with the problem of a tendency to pit, in particular in the middle regions (with relation to the radial axis of the bush), on starting the motor. According to the invention, the problem can be avoided whereby the friction surfaces of a gudgeon pin bush, at least in the high loading region, have the following parameters measured over the bush cross-section in the axial direction: the support percentage is a minimum of 99.0% to a depth of at most 1.800 m, the depth of the roughness core profile is at most 0.30 m, the proportion of the material Mr1 of the roughness core profile is at most 8%. The gudgeon pin bush can be obtained by finishing the bearing surface of the gudgeon pin bush using a surface machining method.

Abstract: A method and an apparatus for testing the adhesive strength of overlays attached to the inside of plain bearing bushings. The method is characterized in specifying clearance between the plain bearing bushing tested and a rotating or oscillating pin extending through the bushing. Next, feeding a liquid medium into the gap between the bushing and the pin and oscillating the plain bearing bushing and pin relative to one another perpendicularly to the bushing axis for a given period and examining the bushing after the load test. The corresponding apparatus comprises a pin mounted rotatably in a pin receptacle and on which there is arranged a first drive mechanism. In addition, a bushing receptacle is provided, in which the plain bearing bushing is fitted, wherein the pin is mounted with predetermined clearance in the bushing. The apparatus additionally comprises a mechanism for bringing about oscillating relative movement of bushing receptacle and pin receptacle.

Abstract: The invention relates to gudgeon pin bushes which find application in highly-stressed engines, with the problem of a tendency to pit, in particular in the middle regions (with relation to the radial axis of the bush), on starting the motor. According to the invention, said problem can be avoided whereby the friction surfaces of a gudgeon pin bush, at least in the high loading region, have the following parameters measured over the bush cross-section in the axial direction: the support percentage is a minimum of 99.0% to a depth of at most 1.800 m, the depth of the roughness core profile is at most 0.30 m, the proportion of the material Mr1 of the roughness core profile is at most 8%. Said gudgeon pin bush can be obtained by means of a finishing for the bearing surface of the gudgeon pin bush using a surface machining method.

Abstract: An ion removal arrangement includes a filter having a filter material made of synthetic or naturally occurring crystalline hydrated aluminum silicates having a framework structure, which contain alkaline or alkaline earth ions. The filter is formed as a double pipe cartridge having an inner pipe and an outer pipe. The filter material is filled in the annular space between the inner pipe and the outer pipe. The filter is installed in the cast iron gutter pipe of a gutter system.

Abstract: An ion removal arrangement includes a filter having a filter material made of synthetic or naturally occurring crystalline hydrated aluminum silicates having a framework structure, which contain alkaline or alkaline earth ions. The filter is formed as a double pipe cartridge having an inner pipe and an outer pipe. The filter material is filled in the annular space between the inner pipe and the outer pipe. The filter is installed in the cast iron gutter pipe of a gutter system.

Abstract: An ion removal arrangement includes a filter having a filter material made of synthetic or naturally occurring crystalline hydrated aluminum silicates having a framework structure, which contain alkaline or alkaline earth ions. The filter is formed as a double pipe cartridge having an inner pipe and an outer pipe. The filter material is filled in the annular space between the inner pipe and the outer pipe. The filter is installed in the cast iron gutter pipe of a gutter system.