Patents by Inventor GERMANA RAPPA

GERMANA RAPPA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF A TRIPARTITE VOR PROTEIN COMPLEX IN MULTICELLULAR ORGANISMS
    Publication number: 20260102391
    Abstract: The present disclosure relates generally to methods of inhibiting a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms, to methods of identifying agents which inhibit such complex and to the medical use of those agents. Inhibition of the VOR complex causes interference with at least one mechanism of intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs, and viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells.
    Type: Application
    Filed: December 15, 2025
    Publication date: April 16, 2026
    Inventors: Aurelio LORICO, Denis CORBEIL, Mark SANTOS, Germana RAPPA
  • Inhibition of a tripartite VOR protein complex in multicellular organisms
    Patent number: 12527789
    Abstract: The present disclosure relates generally to methods of inhibiting a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms, to methods of identifying agents which inhibit such complex and to the medical use of those agents. Inhibition of the VOR complex causes interference with at least one mechanism of intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs, and viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: January 20, 2026
    Assignees: TECHNISCHE UNIVERSITÄT DRESDEN, BASCK INVEST LIMITED
    Inventors: Aurelio Lorico, Denis Corbeil, Mark F. Santos, Germana Rappa
  • USE OF TRIAZOLE ANALOGUES FOR INHIBITION OF A TRIPARTITE VOR PROTEIN COMPLEX IN MULTICELLULAR ORGANISMS
    Publication number: 20230321082
    Abstract: There is disclosed a compound selected from triazole analogues or pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof is for use in inhibiting a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms by interfering with at least one mechanism of: intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs; and viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells.
    Type: Application
    Filed: September 7, 2021
    Publication date: October 12, 2023
    Inventors: AURELIO LORICO, MARK SANTOS, GERMANA RAPPA, PATRIZIA DIANA, GIROLAMO CIRRINCIONE, DENIS CORBEIL