Abstract: A fully or partially implantable analyte sensor for continuously monitoring analyte concentration in a body fluid has a substrate with a first surface configured to face towards the body fluid. The sensor has a working electrode and an interferent electrode. The interferent electrode and the working electrode are electrically separated layers located adjacently on the first surface. The sensor has a further electrode, the further electrode being a counter electrode, a reference electrode or a counter/reference electrode. The working electrode and the interferent electrode each have a layer of a conductive material. The working electrode has an enzyme whereas the interferent electrode is devoid of enzyme. A method for producing the fully or partially implantable analyte sensor for continuously monitoring analyte concentration in a body fluid is also disclosed.

Abstract: A method for determining an analyte concentration in a fluid using an analyte sensor having at least two measurement electrodes is disclosed. One of the measurement electrodes has an analyte-responsive polymer gel. The method includes contacting at least the analyte-responsive polymer gel with the fluid having the analyte, generating a non-continuous fast-transient voltage signal and applying the non-continuous fast-transient voltage signal to the measurement electrodes, measuring a response signal, and evaluating the response signal to determine the analyte concentration.

Abstract: A fully or partially implantable analyte sensor for continuously monitoring analyte concentration in a body fluid has a substrate with a first surface configured to face towards the body fluid. The sensor has a working electrode and an interferent electrode. The interferent electrode and the working electrode are electrically separated layers located adjacently on the first surface. The sensor has a further electrode, the further electrode being a counter electrode, a reference electrode or a counter/reference electrode. The working electrode and the interferent electrode each have a layer of a conductive material. The working electrode has an enzyme whereas the interferent electrode is devoid of enzyme. A method for producing the fully or partially implantable analyte sensor for continuously monitoring analyte concentration in a body fluid is also disclosed.

Abstract: A method of preparing a working electrode on a sensor substrate is disclosed. A sensor substrate is provided and has a first side with at least one conductive trace. A layer of sensing material is applied onto the first side and covers at least a portion of the at least one conductive trace. The sensing material is irradiated with a laser beam to partially remove the layer of the sensing material while preserving a portion of the sensing material covering the at least one conductive trace, resulting in a working electrode on the sensor substrate. A membrane layer is applied that at least partially covers the working electrode. The membrane layer includes a cross-linker that cross-links at least a part of the sensing material. A diffusion step is performed during which the cross-linker in the membrane layer at least partially diffuses into the sensing material.

Abstract: This disclosure relates to a process for forming a membrane on an analyte sensor and further relates to an analyte sensor obtainable by this process. This disclosure also relates to a process for forming a sensing layer on an electrode of an analyte sensor and to an analyte sensor having the sensing layer obtainable by the inventive process as well as the membrane obtainable by the inventive process. The analyte sensors obtainable by the inventive processes may be used for conducting an analyte measurement of a body fluid of a user or a patient. This disclosure may be applied in the field of home care as well as in the field of professional care, such as in hospitals. Other applications are generally feasible.

Abstract: An implantation needle has an implantable element receiving portion, a capsule receiving portion, and a tip portion. The capsule receiving portion has a fixing element such as a mechanical barrier or an adhesive surface. A kit is also provided that includes the implantation needle with an implantable element disposed in the implantable element receiving portion and a capsule disposed in the capsule receiving portion. The instant disclosure also relates to a method for administering an implantable element and a capsule to a subject. The method includes inserting an implantation needle of the implantation kit into a tissue of a subject and discharging the implantable element and capsule into the patient's tissue.

Abstract: A microdialysis catheter for partial implantation is used to supply a perfusion fluid and remove a dialysate, such as glucose, and comprises a carrier, at least one opening in the carrier, and a non-porous coating over the opening. The carrier contains at least one channel for supplying a perfusion fluid and for removing a dialysate and an area intended for implantation. The opening on the carrier has a connection with the channel for the passage of fluid. The non-porous coating is externally bonded to the carrier. The non-poroous coating is diffusion-permeable to an analyte and covers the area intended for implantation and the opening. A process for manufacturing the microdialysis catheter is also disclosed.

Abstract: A fluidic structure and a method for production of a fluidic structure are provided. The method may comprise, in order, introducing at least one externally accessible opening into at least one base substrate of the fluidic structure, partially introducing at least one section of a fluidic conductor, which has at least one inner lumen and at least one conductor wall, in particular of a tube or flexible tube, into the at least one opening, introducing at least one curable fluid sealing material into the at least one opening, entirely or partially curing the at least one fluid sealing material, and producing at least one connecting channel between at least one inner lumen in the at least one fluidic conductor and at least one fluid channel in the fluidic structure, the at least one connecting channel passing through at least one conductor wall.