Patents by Inventor Gerolama Condorelli

Gerolama Condorelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTICANCER APTAMERS AND USES THEREOF
    Publication number: 20230227832
    Abstract: The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.
    Type: Application
    Filed: June 17, 2021
    Publication date: July 20, 2023
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Vittorio DE FRANCISCIS, Gerolama CONDORELLI, Silvia CATUOGNO, Carla Lucia ESPOSITO, Cristina QUINTAVALLE, Francesco INGENITO
  • APTAMERS AGAINST GLIOBLASTOMA
    Publication number: 20220243208
    Abstract: Aptamers identified capable of binding glioblastoma cells, and their use in methods of medical treatment and prophylaxis are disclosed.
    Type: Application
    Filed: May 13, 2020
    Publication date: August 4, 2022
    Applicant: SQUADRA Lifesciences, Inc..
    Inventors: Alessadra Affinito, Cristina Quintavalle, Gerolama Condorelli
  • Neutralizing RNA aptamers
    Patent number: 9234202
    Abstract: Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFR? and are therefore useful in the diagnosis and/or therapy of PDGFR?-associated and hyperproliferative-associated diseases, such as cancer and primary tumor metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2?-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: January 12, 2016
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Laura Cerchia, Gerolama Condorelli, Vittorio De Franciscis
  • NEUTRALIZING RNA APTAMERS AGAINST PDGFBETA AND USES THEREOF IN THE THERAPY AND DIAGNOSIS OF HYPERPROLIFERATIVE DISEASES
    Publication number: 20150275215
    Abstract: Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFR? and are therefore useful in the diagnosis and/or therapy of PDGFR?-associated and hyperproliferative-associated diseases, such as cancer and primary tumour metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2?-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided.
    Type: Application
    Filed: October 4, 2013
    Publication date: October 1, 2015
    Inventors: Laura Cerchia, Gerolama Condorelli, Vittorio De Franciscis
  • Method for obtaining oligonucleotide aptamers and uses thereof
    Patent number: 8492082
    Abstract: The present invention relates to a method for obtaining nucleic acid aptamers that bind to cancer cell-surface epitopes, to the aptamers generated using this method and their use for therapeutic, diagnostic and prognostic purposes.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: July 23, 2013
    Assignee: Consiglio Nazionale delle Richerche
    Inventors: Vittorio De Franciscis, Laura Cerchia, Gerolama Condorelli
  • METHOD FOR OBTAINING OLIGONUCLEOTIDE APTAMERS AND USES THEREOF
    Publication number: 20110166213
    Abstract: The present invention relates to a method for obtaining nucleic acid aptamers that bind to cancer cell-surface epitopes, to the aptamers generated using this method and their use for therapeutic, diagnostic and prognostic purposes.
    Type: Application
    Filed: September 1, 2009
    Publication date: July 7, 2011
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Vittorio De Franciscis, Laura Cerchia, Gerolama Condorelli