Patents by Inventor Gerrit A J Hakkaart

Gerrit A J Hakkaart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100022628
    Abstract: The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and in Drosophila has been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.
    Type: Application
    Filed: July 9, 2009
    Publication date: January 28, 2010
    Inventors: Pierre Jean Frederic Rustin, Howard T. Jacobs, Emmanuel Philippe Dassa, Gerrit A. J. Hakkaart, Daniel Jose Moreno Fernandez-Ayala
  • Patent number: 7572616
    Abstract: The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and in Drosophila has been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: August 11, 2009
    Assignees: Licentia Ltd., INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Pierre Jean Frederic Rustin, Howard T. Jacobs, Emmanuel Philippe Dassa, Gerrit A J Hakkaart, Daniel Jose Moreno Fernandez-Ayala
  • Publication number: 20080103088
    Abstract: The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and in Drosophila has been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.
    Type: Application
    Filed: November 1, 2006
    Publication date: May 1, 2008
    Applicants: LICENTIA LTD., INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Pierre Jean Frederic Rustin, Howard T. Jacobs, Emmanuel Philippe Dassa, Gerrit A. J. Hakkaart, Daniel Jose Moreno Fernandez-Ayala