Abstract: A multi-spindle drilling machine for simultaneously drilling a plurality of holes, in particular suitable for drilling a plurality of tiny, closely-spaced holes, comprising a drivable drive wheel coacting with a plurality of friction wheels, each connected to a flexible spindle, whose ends away from the friction wheels extend through bores in a spaced apart spindle guide block. Said bores correspond with opposite bores in a drill guide block and are disposed in accordance with the pattern of the holes to be drilled. A coupling arrangement is provided in the space between the drill guide block and the spindle guide block for connecting the shanks of drill bits placed in the bores of the drill guide block to the spindles.