Abstract: The invention relates to the adhesion of platelet GpIb? to strand ?3 of domain A1 of von Willebrand factor (vWF), the strand ?3 comprising amino acid residues at amino acid position 560-566 and/or a functional part or equivalent thereof, the platelet GpIb?, the GpIb? region comprising an amino acid sequence corresponding to a beta-switch loop of platelet GpIb?, comprising amino acid residues at amino acid position 227-242 and/or a functional part or equivalent thereof. The invention provides a method of interfering with adhesion of blood platelets to vWF that includes modulating adhesion. The invention further provides proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions to that end. The invention also provides means and methods to increase platelet adhesion by topical application of a compound increasing platelet adhesion.

Abstract: Connecting mechanisms for pivotally coupling a shoe with a sporting device are described. In one embodiment, the connecting mechanism can include a support element for supporting a shoe, a connecting element disposed on a sporting device, and a coupling element for coupling the support element to the connecting element. The support element can include a first end liftably disposable on the sporting device and a second end spaced apart from the first end. The coupling element can include a first end attachable via a first pivot to the second end of the support element and a second end attachable via a second pivot to the connecting element. The first and second pivots can be active successively with the progression of a bending movement of a foot in a shoe supported by the support element.

Abstract: Connecting mechanisms for pivotally coupling a shoe with a sporting device are described. In one embodiment, the connecting mechanism can include a support element for supporting a shoe, a connecting element disposed on a sporting device, and a coupling element for coupling the support element to the connecting element. The support element can include a first end liftably disposable on the sporting device and a second end spaced apart from the first end. The coupling element can include a first end attachable via a first pivot to the second end of the support element and a second end attachable via a second pivot to the connecting element. The first and second pivots can be active successively with the progression of a bending movement of a foot in a shoe supported by the support element.

Abstract: A connecting organ for coupling a shoe with a sporting device such as a skate or a roller skate, ski or the like, such as to be pivotable around a pivoting point, which is equipped with a first and a second pivoting point which during use are successively active with a progression of a foot's bending. the shoe can be mounted onto a support element which at a first end thereof liftably rests upon the sporting device and at a second end removed from the first end is via the first pivoting point connected with an end of a coupling element whose other end is connected via the second pivoting point with a connecting organ that is mounted on the sporting device.

Abstract: The invention relates to a surveillance sensor provided with at least one surveillance radar antenna 1 and at least one co-located and co-rotating electro-optical surveillance sensor 5 mechanically connected to said radar antenna. A combined panoramic picture is compiled by combining information from both sensors using a common track unit 30.