Patents by Inventor Gerrit J. B. Ettema

Gerrit J. B. Ettema has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical tablets of crystalline type II aripiprazole
    Patent number: 8529949
    Abstract: Crystalline aripiprazole Type II can be formulated into pharmaceutical tablets having reduced dissolution profile variability upon storage.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: September 10, 2013
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua, Korinde Annemarie Jansen, Farid Abedin Dorkoosh
  • Process of making crystalline type II aripiprazole
    Patent number: 8093387
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: January 10, 2012
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • Process of making crystalline type II aripiprazole
    Publication number: 20100196710
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Application
    Filed: December 24, 2009
    Publication date: August 5, 2010
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • FULVESTRANT INTERMEDIATE
    Publication number: 20100105934
    Abstract: A compound of formula (1) wherein R1 represents hydrogen or an acetyl group and R2 represents a methyl, acetyl, or benzyl group, is useful as an intermediate in making fulvestrant. The compound (1) can be isolated as a crystalline material and can be provided in a ratio of 7-alpha epimer to 7-beta epimer in the range of 95:5 to 100:0.
    Type: Application
    Filed: October 15, 2009
    Publication date: April 29, 2010
    Inventors: Gerrit J. B. Ettema, Reinerus G. Gieling
  • Process of making crystalline Type II aripiprazole
    Patent number: 7655798
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: February 2, 2010
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • PROCESSES RELATED TO MAKING CAPECITABINE
    Publication number: 20080300399
    Abstract: An intermediate (2) useful in making capecitabine can be formed without the use, or presence, of a silylation agent.
    Type: Application
    Filed: June 2, 2008
    Publication date: December 4, 2008
    Inventor: Gerrit J. B. Ettema
  • Process for making bicalutamide and intermediates thereof
    Patent number: 7186854
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: March 6, 2007
    Assignee: Synthon IP Inc.
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit J. B. Ettema
  • Amlodipine salt forms and processes for preparing them
    Patent number: 6828339
    Abstract: Amlodipine besylate forms are described, including amlodipine besylate hydrates and novel amlodipine besylate anhydrates. A method of making various amlodipine besylate forms from an aqueous medium as well as the use of the same as a calcium channel blocker are described.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: December 7, 2004
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Hans Hoorn, Jacobus M. Lemmens
  • Process for making bicalutamide and intermediates thereof
    Publication number: 20040068135
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Application
    Filed: October 10, 2003
    Publication date: April 8, 2004
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit J. B. Ettema
  • Amlodipine salt forms and processes for preparing them
    Publication number: 20030139455
    Abstract: Amlodipine besylate forms are described, including amlodipine besylate hydrates and novel amlodipine besylate anhydrates. A method of making various amlodipine besylate forms from an aqueous medium as well as the use of the same as a calcium channel blocker are described.
    Type: Application
    Filed: November 20, 2002
    Publication date: July 24, 2003
    Inventors: Gerrit J. B. Ettema, Hans Hoorn, Jacobus M. Lemmens
  • Amlodipine hemimaleate
    Patent number: 6538012
    Abstract: Amlodipine hemimaleate is useful as a calcium channel blocker and can be used to treat or prevent angina or hypertension.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: March 25, 2003
    Assignee: Synthon BV
    Inventor: Gerrit J. B. Ettema
  • Amlodipine hemimaleate
    Publication number: 20020128297
    Abstract: Amlodipine hemimaleate is useful as a calcium channel blocker and can be used to treat or prevent angina or hypertension.
    Type: Application
    Filed: August 27, 2001
    Publication date: September 12, 2002
    Inventor: Gerrit J.B. Ettema