Patents by Inventor Gerrit Jan Bouke Ettema

Gerrit Jan Bouke Ettema has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making bicalutamide and intermediates thereof
    Patent number: 6818766
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: November 16, 2004
    Assignee: Synthon BV
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit Jan Bouke Ettema
  • Process for making bicalutamide and intermediates thereof
    Publication number: 20030073742
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Application
    Filed: October 2, 2002
    Publication date: April 17, 2003
    Applicant: SYNTHON B.V.
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit Jan Bouke Ettema
  • Imidazopyridine derivatives and process for making them
    Patent number: 6281360
    Abstract: Imidazopyridine compounds of the formula 1 are can be made in high purity, e.g. greater than 95% pure, by a process that use a novel intermediate of formula 5: wherein R1 and R2 each independently represent hydrogen or a lower alkyl group and Y and Z each independently represent a lower alkyl group. By this process, zolpidem, a commercial pharmaceutical of the formula 1 can be effectively made.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: August 28, 2001
    Assignee: Synthon BV
    Inventors: Gerrit Jan Bouke Ettema, Jacobus Maria Lemmens, Theodorus Hendricus Antonius Peters, Frantisek Picha
  • Zolpidem salt forms
    Patent number: 6242460
    Abstract: Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5° C./minute from about 25° C. to 250° C. The salts are generally easy to reproduce, even on an industrial scale and are easier to handle due to the increased stability than the known zolpidem tartrate. The zolpidem salts are typically pharmaceutically acceptable salts and can be used in formulating pharmaceutical compositions and in pharmaceutical uses; e.g. as a hypnotic.
    Type: Grant
    Filed: November 26, 1999
    Date of Patent: June 5, 2001
    Assignee: Synthon BV
    Inventors: Gerrit Jan Bouke Ettema, Jacobus Maria Lemmens, Theodorus Hendricus Antonius Peters, Frantisek Picha