Abstract: The treatment of neurodegenerative diseases, i.e. a group of chronic, progressive disorders characterized by the gradual loss of neurons or neuronal function in discrete areas of the central nervous system (CNS). Specifically, alkaline phosphatase (AP) for use in the treatment or prophylaxis of a mammal suffering from or at risk of a neurodegenerative disorder caused by a reduction of Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) activity.

Abstract: Methods for enhancing joint function and for treating or preventing age-related joint discomfort in an adult human are disclosed. The methods comprise administering to the human a dietetic food, medical food, or food supplement. The food or food supplement comprises a rumenic acid-rich conjugated linoleic acid (RAR-CLA), or a pharmaceutically acceptable salt, ester, mono-, di-, or triglyceride, metabolic precursor thereof, or mixture thereof, in an amount effective to enhance joint function or to alleviate joint discomfort in the human. The RAR-CLA comprises cis-9, trans-11 linoleic acid and trans-10, cis-12 linoleic acid isomers in a weight ratio of at least 2:1. Enrichment of a dietetic food, medical food, or food supplement with RAR-CLA can help to improve joint function and/or alleviate joint discomfort. Longer-term studies should help to further elucidate the potential impact of RAR-CLA supplementation on joint function in older adults.

Abstract: Methods for treating or preventing age-related cognitive impairment in an adult human are disclosed. One method comprises administering to an adult human having, or at risk of having, impaired cognitive function a dietetic food, medical food, or food supplement. The food or food supplement comprises a rumenic acid-rich conjugated linoleic acid (RAR-CLA), or a pharmaceutically acceptable salt, ester, mono-, di-, or triglyceride, metabolic precursor thereof, or mixture thereof, in an amount effective to enhance cognitive function in the human. The RAR-CLA comprises cis-9, trans-11 linoleic acid and trans-10, cis-12 linoleic acid isomers in a weight ratio of at least 2:1. Enrichment of a dietetic food, medical food, or food supplement with RAR-CLA can help to improve cognitive function. The impact is particularly evident in aging adult males, as indicated by their improved scores in the Rey Auditory Verbal Learning Test.

Abstract: Methods for enhancing joint function and for treating or preventing age-related joint discomfort in an adult human are disclosed. The methods comprise administering to the human a dietetic food, medical food, or food supplement. The food or food supplement comprises a rumenic acid-rich conjugated linoleic acid (RAR-CLA), or a pharmaceutically acceptable salt, ester, mono-, di-, or triglyceride, metabolic precursor thereof, or mixture thereof, in an amount effective to enhance joint function or to alleviate joint discomfort in the human. The RAR-CLA comprises cis-9, trans-11 linoleic acid and trans-10, cis-12 linoleic acid isomers in a weight ratio of at least 2:1. Enrichment of a dietetic food, medical food, or food supplement with RAR-CLA can help to improve joint function and/or alleviate joint discomfort. Longer-term studies should help to further elucidate the potential impact of RAR-CLA supplementation on joint function in older adults.

Abstract: Methods for treating or preventing age-related cognitive impairment in an adult human are disclosed. One method comprises administering to an adult human having, or at risk of having, impaired cognitive function a dietetic food, medical food, or food supplement. The food or food supplement comprises a rumenic acid-rich conjugated linoleic acid (RAR-CLA), or a pharmaceutically acceptable salt, ester, mono-, di-, or triglyceride, metabolic precursor thereof, or mixture thereof, in an amount effective to enhance cognitive function in the human. The RAR-CLA comprises cis-9, trans-11 linoleic acid and trans-10, cis-12 linoleic acid isomers in a weight ratio of at least 2:1. Enrichment of a dietetic food, medical food, or food supplement with RAR-CLA can help to improve cognitive function. The impact is particularly evident in aging adult males, as indicated by their improved scores in the Rey Auditory Verbal Learning Test.

Abstract: The invention relates to a a microtiter plate and its use in a method of the invention, which microtiter plate comprises a plurality of containers, wherein the bottom of each container comprises a (semi-)permeable membrane capable of directly or indirectly binding an analyte, and wherein each container is separated from an adjacent container by a container dividing wall, wherein the containers are grouped in one or more clusters, each cluster comprising at least two containers, wherein said clusters are separated from adjacent clusters by a cluster dividing wall and wherein at least part of the container dividing wall is lower than the cluster dividing wall or wherein the container dividing wall contains at least one passageway connecting at least two adjacent containers within a cluster, said passageway being at a distance from the bottom of the container and at least partly below the top of the container.