Abstract: A decision support system provides workflow optimization for healthcare providers. A data repository includes patient profile data and receives real-time patient condition data from a sensor network and workflow data for the provider. The system determines a relative risk value for patients with respect to a negative outcome such as hospital transfer, and defines at-risk patients with respect to the determined negative outcome. Positive outcomes having an inverse correlation with respect to the negative outcome are determined, such as hospice admission without transfer. A clinical workflow is defined as a sequence of treatment stages associated with the determined positive outcome, and provider activity tracked for the at-risk patients with respect to first threshold values, the system further tracking a degree of provider compliance with the clinical workflow stages based on second threshold values.