Abstract: The present embodiments relate generally to the field of cancer diagnostics. More specifically the embodiments relate to platelet derived biomarkers used for diagnosis of cancer or cancer progression, as well as prognosis and improved treatment.

Abstract: The present embodiments relate generally to the field of cancer diagnostics. More specifically the embodiments relate to platelet derived biomarkers used for diagnosis of cancer or cancer progression, as well as prognosis and improved treatment.

Abstract: The present invention relates to an anti-seeding arrangement (100) for invasive treatment of a human or animal body comprising an elongated hollow member (102), and a first electrode (116) of which one portion is arranged near one end of the elongated hollow member (102), said first electrode (116) being connectable to an electromagnetic field generator (110), wherein the elongated hollow member (102) is arranged to be inserted into the human or animal body, control means (106, 108) arranged to control the electromagnetic field generator (110) for delivering radio frequency bursts to the first electrode (116), and sensing means (104) to sense a physical property dependent on the insertion length of the elongated hollow member (102) in the human or animal body, and wherein the control means (106, 108) is arranged to control the operation of the electromagnetic field generator (110) in dependence of the sensed physical property.

Abstract: Methods of assessing genomic instability in breast cancer tissue by measuring the expression level of genes CDKN2A, SCYA18, STK15, NXF1, cDNA Dkfzp762M127, p28 KIAA0882, MYB, Human clone 23948, RERG, HNF3A, and ACADSB or a nucleic acid sequence comprising about 90% or greater sequence identity to SEQ ID NO: 21 in breast cancer tissue, an array suitable for use in such methods, and related methods and compositions.

Abstract: The present invention relates to an anti-seeding arrangement (100) for invasive treatment of a human or animal body comprising an elongated hollow member (102), and a first electrode (116) of which one portion is arranged near one end of the elongated hollow member (102), said first electrode (116) being connectable to an electromagnetic field generator (110), wherein the elongated hollow member (102) is arranged to be inserted into the human or animal body, control means (106, 108) arranged to control the electromagnetic field generator (110) for delivering radio frequency bursts to the first electrode (116), and sensing means (104) to sense a physical property dependent on the insertion length of the elongated hollow member (102) in the human or animal body, and wherein the control means (106, 108) is arranged to control the operation of the electromagnetic field generator (110) in dependence of the sensed physical property.

Abstract: The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.

Abstract: Fine needle arrangement for taking a sample of cells from suspicious lesions by using fine needle aspiration (FNA) technique, including a tubular needle member (1), a storage compartment (2) enclosing a chamber, and a coupling (3) to which a connector may be attached. The chamber is configured with a gradually increasing cross-sectional area from the distal part of the chamber to the proximal part of the chamber, such that the chamber has no residual spaces where cell samples may be trapped, and that an efficient air streaming is achieved.

Abstract: Methods of assessing genomic instability in breast cancer tissue by measuring the expression level of genes CDKN2A, SCYA18, STK15, NXF1, cDNA Dkfzp762M127, p28 KIAA0882, MYB, Human clone 23948, RERG, HNF3A, and ACADSB or a nucleic acid sequence comprising about 90% or greater sequence identity to SEQ ID NO: 21 in breast cancer tissue, an array suitable for use in such methods, and related methods and compositions.

Abstract: An arrangement for taking a sample of cells from a suspicious lesion or a tumor with the so called fine needle aspiration technique, provides a good penetration of tumors, especially small and/or hard fibrous tumors, and in the meantime yielding an increased amount of cells in the sample, by applying a longitudinal movement to the needle when the needle is penetrating the tumor and by applying both a rotational and a longitudinal movement to the needle when the needle is positioned inside the tumor. The arrangement is further provided with heat generating elements in order to apply a short pulse of heat to the needle in order to lower the risk for the tumor to spread.

Abstract: The present invention relates to an anti-seeding arrangement (100) for invasive treatment of a human or animal body comprising an elongated hollow member (102), and a first electrode (116) of which one portion is arranged near one end of the elongated hollow member (102), said first electrode (116) being connectable to an electromagnetic field generator (110), wherein the elongated hollow member (102) is arranged to be inserted into the human or animal body, control means (106, 108) arranged to control the electromagnetic field generator (110) for delivering radio frequency bursts to the first electrode (116), and sensing means (104) to sense a physical property dependent on the insertion length of the elongated hollow member (102) in the human or animal body, and wherein the control means (106, 108) is arranged to control the operation of the electromagnetic field generator (110) in dependence of the sensed physical property.

Abstract: Fine needle arrangement for taking a sample of cells from suspicious lesions by using fine needle aspiration (FNA) technique, including a tubular needle member (1), a storage compartment (2) enclosing a chamber, and a coupling (3) to which a connector may be attached. The chamber is configured with a gradually increasing cross-sectional area from the distal part of the chamber to the proximal part of the chamber, such that the chamber has no residual spaces where cell samples may be trapped, and that an efficient air streaming is achieved.

Abstract: The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.

Abstract: An arrangement for taking a sample of cells from a suspicious lesion or a tumour with the so called fine needle aspiration technique, provides a good penetration of tumours, especially small and/or hard fibrous tumours, and in the meantime yielding an increased amount of cells in the sample, by applying a longitudinal movement to the needle when the needle is penetrating the tumour and by applying both a rotational and a longitudinal movement to the needle when the needle is positioned inside the tumour. The arrangement is further provided with heat generating elements in order to apply a short pulse of heat to the needle in order to lower the risk for the tumour to spread.

Abstract: Arrangement for treatment of a tumour localized inside a body, comprising a needle that is intended to be inserted into said tumour, a ground electrode that is intended to be applied to the outer surface of the body, and a radio frequency generating device that is intended to apply radio frequency energy between the needle and the ground electrode such that heat is generated in tissue surrounding the needle. The arrangement further comprises novel temperature measurement means and means that provides for a better penetration of the needle into the tumour in comparison with prior art RFA arrangements.

Abstract: An arrangement for sinus evacuation and for taking a sample of bone marrow during a bone marrow aspiration procedure as well as a bone marrow biopsy procedure. By applying a longitudinal movement to the needle when the needle is penetrating the bone the penetration force is reduced which lower the risk of penetrating the posterior cortex or the second sinus wall. The arrangement further includes a stopping element that prevents the needle to penetrate deeper than to a predetermined depth. The arrangement further includes longitudinal movement a stopping element that provides for an active break of the longitudinal movement of the needle when the needle has penetrated down to the predetermined depth.

Abstract: The invention provides a method of detecting the presence of invasive cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality which is associated with invasive cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of invasive cervical carcinoma in the subject. The invention also provides a method of detecting the presence of advanced-stage cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality associated with advanced-stage cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of advanced-stage cervical carcinoma in the subject.