Abstract: The present disclosure relates to a chemical compound having the general formula (I): wherein R1 is a phenyl group and R2 is a meta-substituted phenyl group; and RTA is a substituted or unsubstituted thiazole ring. The disclosure also relates to said compound according to formula (I), in particular in its diastereomerically pure or enriched form, for use in therapy, in particular for treating and/or preventing age-related cognitive decline. Further, the disclosure relates to said compound according to formula (I) for use in improving cognitive functions, in particular for use in improving the spatial learning capabilities in human individuals. And, disclosure also relates to said compound according to formula (I) for use in the treatment and/or prevention of alcohol addiction, nicotine addiction and/or drug addiction, in particular cocaine and/or metamphetamine addiction.

Abstract: The present invention relates to the (S)-enantiomer of the chemical compound having the general formula (I): wherein R1 and R2 are, equal or independently, aryl, heteroaryl, fused aryl, fused heteroaryl, mono or multi-substituted aryl, mono or multi-substituted heteroaryl, mono or multi-substituted fused aryl, mono or multi-substituted fused heteroaryl; and RTA is a 2-1,3-, or 4-1,3-or 5-1,3-thiazole ring with the general Formula (IIa), which can also be substituted. The invention also relates to said compound according to formula (I) for use in improving motivation and/or cognitive functions and/or for use in improving the reference memory in human individuals.

Abstract: The present disclosure relates to a chemical compound having the general formula wherein R1 and R2 are, equal or independently, aryl, heteroaryl; wherein RTA is a 2-1,3-, or 4-1,3- or 5-1,3-thiazole ring and its use in for improving the short term memory and/or the working memory.

Abstract: The present disclosure relates to a chemical compound having the general formula wherein R1 and R2 are, equal or independently, aryl, heteroaryl; wherein RTA is a 2-1,3-, or 4-1,3- or 5-1,3-thiazole ring and its use in for improving the short term memory and/or the working memory.

Abstract: Pathological collagen cross-linking, caused in diabetes patients on account of the higher glucose concentrations, may be inhibited by means of arginine, spermidine, creatine, or agmatine, or a pharmaceutically acceptable salt thereof, in the amount of 1 to 4 g/day.