Patents by Inventor Gertruda Antonetta Philomina Van Helvoirt

Gertruda Antonetta Philomina Van Helvoirt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing simvastatin and/or its derivatives
    Publication number: 20020035274
    Abstract: A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring.
    Type: Application
    Filed: June 18, 2001
    Publication date: March 21, 2002
    Inventors: Frans Van Dalen, Jacobus Maria Lemmens, Gertruda Antonetta Philomina Van Helvoirt, Theororus Hendricus Antonius Peters, Frantisek Picha
  • Process for producing simvastatin and/or its derivatives
    Patent number: 6271398
    Abstract: A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring. R1 is hydrogen or methyl; R2 represents a straight or branched chain alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, or an aralkyl group having 1 to 6 carbon atoms in the alkyl chain; R3 and R4 each independently represent an alkyl group, an ether group, a thioether group, an aryl group, an aralkyl group, an alkenyl group, a cyclic ether group, or a cyclic thioether group; and R5 and R6 each independently represent hydrogen, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, or an ether group.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: August 7, 2001
    Assignee: Synthon BV
    Inventors: Frans Van Dalen, Jacobus Maria Lemmens, Gertruda Antonetta Philomina Van Helvoirt, Theororus Hendricus Antonius Peters, Frantisek Picha
  • Process for producing simvastatin and/or its derivatives
    Patent number: 6100407
    Abstract: A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring. R.sup.1 is hydrogen or methyl; R.sup.2 represents a straight or branched chain alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, or an aralkyl group having 1 to 6 carbon atoms in the alkyl chain; R.sup.3 and R.sup.4 each independently represent an alkyl group, an ether group, a thioether group, an aryl group, an aralkyl group, an alkenyl group, a cyclic ether group, or a cyclic thioether group; and R.sup.5 and R.sup.6 each independently represent hydrogen, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, or an ether group.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: August 8, 2000
    Assignee: Sython, B.V.
    Inventors: Frans Van Dalen, Jacohus Maria Lemmens, Gertruda Antonetta Philomina Van Helvoirt, Theororus Hendricus Antonius Peters, Frantisek Picha