Patents by Inventor Gerwin Puppels
Gerwin Puppels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100309466Abstract: A spectroscopic apparatus, a method of determining a concentration and/or spatial gradient of an analyte of a bodily fluid and a corresponding computer program product are provided. The spectroscopic apparatus provides determination of a position of a capillary vessel (104) within a biological sample in order to focus spectroscopic excitation radiation to a volume (122). that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus, method, and computer program product advantageously exploit the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel.Type: ApplicationFiled: April 19, 2006Publication date: December 9, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Gerhardus Lucassen, Rufus Driessen, Kristiane Schmidt, Gerwin Puppels, Peter Caspers
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Publication number: 20070252978Abstract: The present invention provides for a method of optical spectroscopy, in particular Raman spectroscopy for performing invasive or non-invasive blood analysis. The fluorescence component of return radiation which is received from a detection volume is eliminated which is enabled by the usage of a pulsed excitation light source. The pulse length is substantially shorter than the fluorescence life time Hence, the elimination of the fluorescence composent can be performed by time gating or by other electronics or optical means.Type: ApplicationFiled: December 13, 2004Publication date: November 1, 2007Applicant: KONINKLIJKE PHILIPS ELECTRONICS NVInventors: Marjolein Van Der Voort, Gerhardus Lucassen, Gerwin Puppels, Michael Van Beek, Coen Theodorus Hubertus Liedenbaum
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Publication number: 20070175278Abstract: An instrument, method, use and software program to obtain information rapidly about microorganisms that may spread uncontrolled in hospitals, water supply, food or when used in bio terrorism are described. Vibrational spectroscopy provides data to a computer linked to one or more databases. Comparison of the spectral data and information retrieved from the databases is used to identify and classify the microorganisms, applying suitable algorithms, which algorithms are self-generating and self-adapting to new spectroscopic data. The system may alert for the detection of an outbreak or to take disinfection measures. Changes in the traditional taxonomic division of microorganisms have no influence on the instrument. It does not rely on an a priori knowledge about the taxonomic classification of the microbial strain, is straightforward and easily integrated in routine microbial procedures.Type: ApplicationFiled: May 11, 2004Publication date: August 2, 2007Applicant: ERASUMS UNIVERSITY MEDICAL CENTER rOTTERDAM (ERASUMUS MC )Inventors: Gerwin Puppels, Tom Bakker Schut, Kornelis Maquelin
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Publication number: 20070049830Abstract: An analysis apparatus, in particular a spectroscopic analysis apparatus, comprises an excitation system for emitting an excitation beam to excite a target region. A a monitoring system images the target region. The monitoring system being arranged to produce a contrast image in a contrast wavelength range and produce a reference image in a reference wavelength range. the contrast image and the reference image are compared to accurately identify the target region, notably a capillary blood vessel in the patient's skin.Type: ApplicationFiled: March 15, 2004Publication date: March 1, 2007Inventors: Robert Hendriks, Gerhardus Lucassen, Marjolein Van Der Voort, Gerwin Puppels, Michael Van Beek
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Publication number: 20060139633Abstract: The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm?1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.Type: ApplicationFiled: December 2, 2003Publication date: June 29, 2006Inventors: Gerwin Puppels, Rolf Wolthus, Senada Koljenovic
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Publication number: 20060135861Abstract: The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for blood analysis on vessels. An excitation system (exs) emits an excitation beam to excite a target region. A detection system (dsy) is provided for detecting and analyzing scattered radiation from the target region. Those areas are selected or predetermined so that only scattered radiation from blood in capillaries having a diameter below a predetermined diameter value and/or including an amount of red blood cells below a predetermined cell amount is analyzed. Thus, in contrast to analysis on whole blood or large amounts of blood cells less reabsorption and scattering of Raman light due to red blood cells is obtained. Further, the possibility to directly measure in the blood plasma without interference of the red blood cells, thereby yielding a higher signal-to-noise ratio, is given.Type: ApplicationFiled: January 19, 2004Publication date: June 22, 2006Applicant: Koninklijke Philips Electronics N.V.Inventors: Gerhardus Lucassen, Gerwin Puppels, Marjolein Van Der Voort, Rolf Wolthuis
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Publication number: 20060129036Abstract: The present invention relates to a spectroscopic apparatus for non-invasive in vivo analysis of blood and to a corresponding analysis method, in particular for direct determination of the pH value of the blood. From a Raman signal detected from an excited target region containing blood at least one predetermined pH sensitive signal portion is determined, from which the pH value of the blood in the target region by use of a relationship between pH value and one or more band parameters of pH sensitive vibrations of at least one molecule or part of a molecule present in blood, in particular heme vibrations of hemoglobin, is determined.Type: ApplicationFiled: May 27, 2004Publication date: June 15, 2006Inventors: Gerhardus Lucassen, Gerwin Puppels
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Publication number: 20060100524Abstract: The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analysing an object, such as the blood of a patient, and a corresponding analysis method. An excitation system (exs) emits an excitation beam (exb) to excite a target region and a beam separation unit (hm) separates at least part of elastically scattered radiation from inelastically scattered radiation, said scattered radiation being generated by the excitation beam (exb) at the target region. A monitoring system (lso) generates an image of the target region using the elastically scattered or the inelastically scattered radiation and defines a region of interest in said image.Type: ApplicationFiled: December 4, 2003Publication date: May 11, 2006Inventors: Gerhardus Lucassen, Gerwin Puppels, Marjolein Van Der Voort
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Publication number: 20050179895Abstract: Incoming light is spectrally analyzed by diffracting the incoming light with a grating. At least a part of the incoming light is split off so that this part contains mainly one polarization component of the incoming light. It is ensured that this split-off part and a remaining part of the incoming light reach the grating with their polarized component mainly parallel to a main direction of polarization which is diffracted with maximal efficiency by the grating. For this purpose, at least the split-off part is diffracted after being passed through a polarization rotating element.Type: ApplicationFiled: January 12, 2005Publication date: August 18, 2005Inventor: Gerwin Puppels
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Publication number: 20050117150Abstract: A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.Type: ApplicationFiled: February 28, 2002Publication date: June 2, 2005Inventors: Gerwin Puppels, Peter Caspers, Gerhardus Lucassen