Abstract: A pharmaceutical composition and a health functional food composition for alleviating eye fatigue containing, as active ingredients, compounds, particularly, luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide isolated from a Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo leaf extract have an effect of alleviating eye fatigue by increasing the contents of NO and cGMP associated with relaxation of ciliary smooth muscle cells isolated from rat's eyes and decreasing the content of [Ca2+]i, and increasing cGMP which is a factor associated with relaxation of the ciliary smooth muscle through an animal experiment. As a result, the luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds extracted from Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo may be usefully used as a pharmaceutical composition and a health functional food composition having an eye fatigue alleviating effect as a Korean natural resource.

Abstract: Provided is a method of preparing a vinyl chloride-vinyl acetate copolymer latex. Specifically, in one embodiment of the present invention, provided is a method of preparing a latex including vinyl chloride-vinyl acetate copolymer particles with a high degree of polymerization and molecular weight and a uniform particle composition by performing an emulsion polymerization of a vinyl chloride monomer and a vinyl acetate monomer in the presence of an aqueous dispersion medium and an emulsifier while optimizing a feeding mode of the vinyl chloride monomer and the emulsifier.

Abstract: Provided is a method of preparing a vinyl chloride-acrylic copolymer latex. Specifically, in one embodiment of the present invention, provided is a method of preparing a latex including vinyl chloride-acrylic copolymer particles with a high degree of polymerization and high molecular weight by performing an emulsion polymerization of a vinyl chloride monomer and an acrylic monomer in the presence of an aqueous dispersion medium and an emulsifier while optimizing a feeding mode of the monomers and the emulsifier.

Abstract: The present invention, it was confirmed that a pharmaceutical composition and a health functional food composition for alleviating eye fatigue containing, as active ingredients, compounds, particularly, luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide isolated from a Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo leaf extract have an effect of alleviating eye fatigue by increasing the contents of NO and cGMP associated with relaxation of ciliary smooth muscle cells isolated from rat's eyes and decreasing the content of [Ca2+]i, and increasing cGMP which is a factor associated with relaxation of the ciliary smooth muscle through an animal experiment. As a result, the luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds extracted from Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo may be usefully used as a pharmaceutical composition and a health functional food composition having an eye fatigue alleviating effect as a Korean natural resource.