Patents by Inventor Geza Erdos
Geza Erdos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230311426Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.Type: ApplicationFiled: March 8, 2023Publication date: October 5, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
-
Publication number: 20230285731Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.Type: ApplicationFiled: April 28, 2023Publication date: September 14, 2023Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Geza Erdos
-
Patent number: 11744927Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.Type: GrantFiled: April 28, 2020Date of Patent: September 5, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
-
Patent number: 11684763Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.Type: GrantFiled: October 17, 2016Date of Patent: June 27, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Jr., Geza Erdos
-
Patent number: 11672964Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.Type: GrantFiled: July 29, 2020Date of Patent: June 13, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Jr., Geza Erdos
-
Publication number: 20230145599Abstract: Provided herein are microneedle array devices for delivery of recombinant adenovirus particles, methods of making the devices, and used for the devices. The microneedle array devices are storage-stable at 4° C., retaining adenovirus infectivity for at least one month.Type: ApplicationFiled: April 8, 2021Publication date: May 11, 2023Inventors: Louis Falo, Jr., Andrea A. Gambotto, Geza Erdos
-
Publication number: 20220193386Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.Type: ApplicationFiled: January 14, 2022Publication date: June 23, 2022Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
-
Publication number: 20210187262Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.Type: ApplicationFiled: December 23, 2020Publication date: June 24, 2021Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
-
Patent number: 10913776Abstract: Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.Type: GrantFiled: September 29, 2017Date of Patent: February 9, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Andrea A. Gambotto, Eun Kim, Geza Erdos, Louis D. Falo, Jr.
-
Patent number: 10894151Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.Type: GrantFiled: April 22, 2016Date of Patent: January 19, 2021Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
-
Publication number: 20200397955Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.Type: ApplicationFiled: April 28, 2020Publication date: December 24, 2020Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
-
Publication number: 20200353235Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.Type: ApplicationFiled: July 29, 2020Publication date: November 12, 2020Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, JR., Geza Erdos
-
Patent number: 10737083Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.Type: GrantFiled: February 22, 2019Date of Patent: August 11, 2020Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Jr., Geza Erdos
-
Publication number: 20200031874Abstract: Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.Type: ApplicationFiled: September 29, 2017Publication date: January 30, 2020Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Andrea A. Gambotto, Eun Kim, Geza Erdos, Louis D. Falo, JR.
-
Patent number: 10441768Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.Type: GrantFiled: March 18, 2016Date of Patent: October 15, 2019Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Jr., Geza Erdos
-
Publication number: 20190255307Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.Type: ApplicationFiled: February 22, 2019Publication date: August 22, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, JR., Geza Erdos
-
Publication number: 20180304062Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.Type: ApplicationFiled: October 17, 2016Publication date: October 25, 2018Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Louis D. FALO, JR., Geza ERDOS
-
Publication number: 20180272621Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.Type: ApplicationFiled: March 26, 2018Publication date: September 27, 2018Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
-
Publication number: 20180119077Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.Type: ApplicationFiled: April 22, 2016Publication date: May 3, 2018Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
-
Patent number: 9944019Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.Type: GrantFiled: May 1, 2013Date of Patent: April 17, 2018Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar