Patents by Inventor Geza Erdos

Geza Erdos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220193386
    Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: January 14, 2022
    Publication date: June 23, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20210187262
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Application
    Filed: December 23, 2020
    Publication date: June 24, 2021
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Patent number: 10913776
    Abstract: Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 9, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Andrea A. Gambotto, Eun Kim, Geza Erdos, Louis D. Falo, Jr.
  • Patent number: 10894151
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: January 19, 2021
    Assignees: Carnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Publication number: 20200397955
    Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
    Type: Application
    Filed: April 28, 2020
    Publication date: December 24, 2020
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20200353235
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Geza Erdos
  • Patent number: 10737083
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: August 11, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos
  • Publication number: 20200031874
    Abstract: Disclosed is an immunogen comprising a fusion protein, wherein the fusion protein comprises a Zika virus (ZIKV) envelope protein, optionally a signal peptide, and a multimerization domain. The signal peptide is a premembrane (prM) signal peptide, an IgG signal peptide, or a human secretory signal peptide hidden Markov model, and the multimerization domain is an immunoglobulin Fc domain, a T4 fibritin foldon trimerization domain, or a human collagen XV trimerization domain. Nucleic acids, vectors, and microneedle arrays including these compositions are disclosed. Methods of producing an immune response to ZIKV are also disclosed.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 30, 2020
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Andrea A. Gambotto, Eun Kim, Geza Erdos, Louis D. Falo, JR.
  • Patent number: 10441768
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: October 15, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos
  • Publication number: 20190255307
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 22, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Geza Erdos
  • Publication number: 20180304062
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.
    Type: Application
    Filed: October 17, 2016
    Publication date: October 25, 2018
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. FALO, JR., Geza ERDOS
  • Publication number: 20180272621
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: March 26, 2018
    Publication date: September 27, 2018
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20180119077
    Abstract: Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
    Type: Application
    Filed: April 22, 2016
    Publication date: May 3, 2018
    Inventors: O. Burak Ozdoganlar, Marcel P. Bruchez, Phil G. Campbell, Jonathan W. Jarvik, Louis Falo, Geza Erdos
  • Patent number: 9944019
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: April 17, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20160271381
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Application
    Filed: March 18, 2016
    Publication date: September 22, 2016
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, JR., Geza Erdos
  • Publication number: 20160136407
    Abstract: A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more chemotherapeutic agents can be present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: November 6, 2015
    Publication date: May 19, 2016
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20150126923
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: May 1, 2013
    Publication date: May 7, 2015
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20140350472
    Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
    Type: Application
    Filed: August 12, 2014
    Publication date: November 27, 2014
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Patent number: 8834423
    Abstract: A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: September 16, 2014
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20110144318
    Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.
    Type: Application
    Filed: August 15, 2007
    Publication date: June 16, 2011
    Inventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu