Patents by Inventor Ghebre Egziabher Tzeghai
Ghebre Egziabher Tzeghai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11357250Abstract: The invention encompasses compositions and methods for effectively treating and/or preventing diabetes and/or obesity. This is accomplished by totally addressing the multiple mechanisms that lead to such conditions. The invention includes compositions comprising a combination of agents that effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that lead to diabetes and obesity.Type: GrantFiled: August 11, 2017Date of Patent: June 14, 2022Assignee: Summit Innovation Labs LLCInventors: Haile Mehansho, Satyanarayana Majeti, Ghebre Egziabher Tzeghai
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Patent number: 11344575Abstract: The invention encompasses compositions and methods for effectively interfering, reducing and preventing conversion of vascular smooth muscle cells (VSMCs) and circulating stem cells to osteoblastic bone-like cells, thereby reducing and/or preventing vascular calcification (VC) or calcium mineral (hydroxyapatite) deposition in the vasculature. The severity and extent of calcification in the major arteries reflect atherosclerotic plaque burden and strongly predict cardiovascular morbidity and mortality.Type: GrantFiled: July 13, 2017Date of Patent: May 31, 2022Assignee: Summit Innovation Labs, LLCInventors: Satyanarayana Majeti, Haile Mehansho, Ghebre Egziabher Tzeghai
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Patent number: 11039636Abstract: The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoporosis and related disorders such as osteoarthritis and rheumatoid arthritis, and for promoting overall bone and joint health. This is accomplished by addressing multiple key mechanisms that lead to such disorders. The invention includes compositions comprising a combination of agents having biological activities that effectively suppress, regulate or interfere with the various key biochemical processes and mechanisms that increase the risk for development and/or progression of osteoporosis. The present compositions and methods simultaneously promote bone formation and reduce bone resorption by (a) stimulating osteoblast formation and osteogenesis; (b) suppressing adipocyte differentiation; (c) inhibiting osteoclast formation; and (d) increasing apoptosis of osteoclasts.Type: GrantFiled: May 13, 2019Date of Patent: June 22, 2021Assignee: Summit Innovation Labs, LLCInventors: Ghebre Egziabher Tzeghai, Haile Mehansho, Satyanarayana Majeti
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Patent number: 11007171Abstract: The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoarthritis and rheumatoid arthritis and for promoting overall joint health. This is accomplished by totally addressing the key multiple biochemical processes and mechanisms that lead to such disorders. The invention includes compositions comprising a combination of natural agents that safely and effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that increase the risk for or lead to the development and/or progression of OA and RA.Type: GrantFiled: July 31, 2018Date of Patent: May 18, 2021Assignee: Summit Innovation Labs, LLCInventors: Haile Mehansho, Satyanarayana Majeti, Ghebre Egziabher Tzeghai
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Publication number: 20190261668Abstract: The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoporosis and related disorders such as osteoarthritis and rheumatoid arthritis, and for promoting overall bone and joint health. This is accomplished by addressing multiple key mechanisms that lead to such disorders. The invention includes compositions comprising a combination of agents having biological activities that effectively suppress, regulate or interfere with the various key biochemical processes and mechanisms that increase the risk for development and/or progression of osteoporosis. The present compositions and methods simultaneously promote bone formation and reduce bone resorption by (a) stimulating osteoblast formation and osteogenesis; (b) suppressing adipocyte differentiation; (c) inhibiting osteoclast formation; and (d) increasing apoptosis of osteoclasts.Type: ApplicationFiled: May 13, 2019Publication date: August 29, 2019Applicant: Summit Innovation Labs LLCInventors: Ghebre Egziabher Tzeghai, Haile Mehansho, Satyanarayana Majeti
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Publication number: 20190015448Abstract: The invention encompasses compositions and methods for effectively treating and/or preventing osteoporosis and related disorders such as osteoarthritis and rheumatoid arthritis, and for promoting overall bone and joint health. This is accomplished by totally addressing the multiple mechanisms that lead to such disorders. The invention includes compositions comprising a combination of agents that effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that increase the risk for development of osteoporosis. The present compositions and methods simultaneously promote bone formation and reduce bone resorption by (a) stimulating osteoblast formation and osteogenesis; (b) suppressing adipocyte differentiation; (c) inhibiting osteoclast formation; and (d) increasing apoptosis of osteoclasts.Type: ApplicationFiled: February 28, 2018Publication date: January 17, 2019Applicant: Summit Innovation Labs LLCInventors: Ghebre Egziabher Tzeghai, Satyanarayana Majeti, Haile Mehansho
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Publication number: 20190015384Abstract: The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoarthritis and rheumatoid arthritis and for promoting overall joint health. This is accomplished by totally addressing the key multiple biochemical processes and mechanisms that lead to such disorders. The invention includes compositions comprising a combination of natural agents that safely and effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that increase the risk for or lead to the development and/or progression of OA and RA.Type: ApplicationFiled: July 31, 2018Publication date: January 17, 2019Applicant: Summit Innovation Labs LLCInventors: Haile Mehansho, Satyanarayana Majeti, Ghebre Egziabher Tzeghai
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Publication number: 20180042962Abstract: The invention encompasses compositions and methods for effectively interfering, reducing and preventing conversion of vascular smooth muscle cells (VSMCs) and circulating stem cells to osteoblastic bone-like cells, thereby reducing and/or preventing vascular calcification (VC) or calcium mineral (hydroxyapatite) deposition in the vasculature. The severity and extent of calcification in the major arteries reflect atherosclerotic plaque burden and strongly predict cardiovascular morbidity and mortality.Type: ApplicationFiled: July 13, 2017Publication date: February 15, 2018Applicant: Summit Innovation Labs LLCInventors: Satyanarayana Majeti, Haile Mehansho, Ghebre Egziabher Tzeghai
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Patent number: 5902570Abstract: Disclosed are anhydrous antiperspirant cream compositions that are substantially free of polymeric or inorganic thickening, and have improved product stability and spreading performance. These compositions have a rheology profile characterized by select product hardness (from about 75 gram force to about 500 gram force), delta stress (from about 300 dyne/cm.sup.2 to about 8,000 dyne/cm.sup.2) and static yield stress (at least about 1,000 dyne/cm.sup.2 ) values. The new rheology profile is preferably applied to antiperspirant cream compositions comprising from about 0.1% to about 20 % by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant having a solubility parameter of from about 3 to about 13 and, from about 5 % to about 35% by weight of a particulate antiperspirant active.Type: GrantFiled: February 13, 1998Date of Patent: May 11, 1999Assignee: Procter & Gamble CompanyInventors: Eric John Bretzler, deceased, Christine Marie Putman, Ghebre Egziabher Tzeghai, David Frederick Swaile
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Patent number: 5891425Abstract: Disclosed are anhydrous antiperspirant cream compositions that are substantially free of polymeric or inorganic thickening, and have improved product stability and spreading performance. These compositions have a rheology profile characterized by select product hardness (from about 75 gram force to about 500 gram force), delta stress (from about 300 dyne/cm.sup.2 to about 8,000 dyne/cm.sup.2) and static yield stress (at least about 1,000 dyne/cm.sup.2) values. The new rheology profile is preferably applied to antiperspirant cream compositions comprising from about 0.1% to about 20% by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant having a solubility parameter of from about 3 to about 13 and, from about 5% to about 35% by weight of a particulate antiperspirant active.Type: GrantFiled: February 13, 1998Date of Patent: April 6, 1999Assignee: Procter & Gamble CompanyInventors: Eric John Bretzler, deceased, Christine Marie Putman, Ghebre Egziabher Tzeghai, David Frederick Swaile
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Patent number: 5891424Abstract: Disclosed are anhydrous antiperspirant cream compositions that are substantially free of polymeric or inorganic thickening, and have improved product stability and spreading performance. These compositions have a rheology profile characterized by select product hardness (from about 75 gram force to about 500 gram force), delta stress (from about 300 dyne/cm.sup.2 to about 8,000 dyne/cm.sup.2) and static yield stress (at least about 1,000 dyne/cm.sup.2) values. The new rheology profile is preferably applied to antiperspirant cream compositions comprising from about 0.1% to about 20% by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant having a solubility parameter of from about 3 to about 13 and, from about 5% to about 35% by weight of a particulate antiperspirant active.Type: GrantFiled: February 13, 1998Date of Patent: April 6, 1999Assignee: Procter & GambleInventors: Eric John Bretzler, deceased, Christine Marie Putman, Ghebre Egziabher Tzeghai, David Frederick Swaile
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Patent number: 5871717Abstract: Disclosed are anhydrous antiperspirant cream compositions that are substantially free of polymeric or inorganic thickening, and have improved product stability and spreading performance. These compositions have a rheology profile characterized by select product hardness (from about 75 gram force to about 500 gram force), delta stress (from about 300 dyne/cm.sup.2 to 8,000 dyne/cm.sup.2) and static yield stress (at least about 1,000 dyne/cm.sup.2) values. The new rheology profile is preferably applied to antiperspirant cream compositions comprising from about 0.1% to about 20% by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant having a solubility parameter of from about 3 to about 13 and, from about 5% to about 35% by weight of a particulate antiperspirant active.Type: GrantFiled: October 29, 1996Date of Patent: February 16, 1999Assignee: Procter & Gamble CompanyInventors: Eric John Bretzler, deceased, Christine Marie Putman, Ghebre Egziabher Tzeghai, David Frederick Swaile
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Patent number: 5849276Abstract: Disclosed are anhydrous antiperspirant compositions comprising from about 0.5% to about 60% by weight of particulate antiperspirant active; from about 1% to about 15% by weight of a solid non-polymeric gellant; from about 10% to about 80% by weight of an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm.sup.3).sup.0.5 ; and from about 0.0001% to about 5.0% by weight of a solid nucleating agent wherein the molar ratio of the solid non-polymeric gellant to the nucleating agent is from about 10:1 to about 1000:1. These antiperspirant compositions provide improved low residue performance and improved antiperspirant efficacy.Type: GrantFiled: December 20, 1996Date of Patent: December 15, 1998Assignee: Procter & GambleInventors: Gerald John Guskey, Curtis Bobby Motley, Ghebre Egziabher Tzeghai