Patents by Inventor Gholam A. Peyman

Gholam A. Peyman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210290373
    Abstract: An apparatus has central lens body for providing vision correction for a patient. The lens body has a central aperture and is configured as one of: a diffractive lens or a refractive lens.
    Type: Application
    Filed: January 18, 2021
    Publication date: September 23, 2021
    Inventors: Gholam Peyman, Lisa Brothers Arbisser
  • Patent number: 11090385
    Abstract: A method of therapy for a tumor or other pathology by administering a combination of thermotherapy and immunotherapy optionally combined with gene delivery. The combination therapy beneficially treats the tumor and prevents tumor recurrence, either locally or at a different site, by boosting the patient's immune response both at the time of original therapy and/or for later therapy. With respect to gene delivery, the inventive method may be used in cancer therapy, but is not limited to such use; it will be appreciated that the inventive method may be used for gene delivery in general. The controlled and precise application of thermal energy enhances gene transfer to any cell, whether the cell is a neoplastic cell, a pre-neoplastic cell, or a normal cell.
    Type: Grant
    Filed: June 10, 2018
    Date of Patent: August 17, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210228619
    Abstract: A method of treating, reducing, or alleviating a medical condition in a patient is disclosed herein. The method includes administering to a patient in need thereof a biocompatible drug comprising one or more antiviral medications together with one or more cell pathway inhibitors, the patient having at least one of a respiratory tract inflammatory disease, a central nervous system inflammatory disease, and vasculitis. The one or more antiviral medications preventing an attachment of viruses to cell walls, blocking a penetration of the viruses into cells, and/or inhibiting virus replication by damaging nucleic acids of the viruses. The one or more cell pathway inhibitors blocking an inflammatory response of inflamed tissue without inhibiting an immune response of the patient.
    Type: Application
    Filed: February 20, 2021
    Publication date: July 29, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210220480
    Abstract: Cancer treatment and imaging methods using thermotherapy and drug delivery are disclosed herein. In one embodiment, the method comprises the steps of administering a plurality of antibody or aptamer-conjugated nanoparticles, liposomes, and/or micelles containing a medication and/or gene to a patient in need thereof so as to target a tumor in the patient, at least some of the antibody or aptamer-conjugated nanoparticles, liposomes, and/or micelles attaching to surface antigens of tumor cells of the tumor so as to form a tumor cell/nanoparticle/liposome/micelle complex; and heating the antibody or aptamer-conjugated nanoparticles, liposomes, and/or micelles using an energy source so as to raise the temperature of the tumor cell/nanoparticle complex, micelle complex, and/or liposome complex, thereby releasing one or more medications from the antibody or aptamer-conjugated nanoparticles, liposomes, and/or micelles, and damaging one or more tumor cell membranes at the tumor site.
    Type: Application
    Filed: April 1, 2021
    Publication date: July 22, 2021
    Inventor: Gholam A. Peyman
  • Patent number: 11045352
    Abstract: Methods for treatment of dry eye and other acute or chronic inflammatory processes are disclosed herein. One method includes administering a drug delivery implant to a patient in need thereof, the drug delivery implant comprising one or more Rock inhibitors and/or one or more Wnt inhibitors, the patient having a medical condition selected from the group consisting of dry eye, lichen planus, arthritis, psoriasis, plantar fasciitis, pars planitis, scleritis, keratitis, chronic meibomian gland inflammation, optic nerve neuritis, uveitis, papillitis, diabetic neural pain, diabetic retinopathy, a cataract, a side effect occurring after refractive surgery, a side effect occurring after corneal transplant, a side effect occurring after retinal detachment surgery, and combinations thereof. The administration of the drug delivery implant to the patient treats the medical condition, reduces the symptoms associated with the medical condition, enhances nerve regeneration, and/or alleviates the medical condition.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: June 29, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210165207
    Abstract: Fluidic glasses for correcting refractive errors of a human or animal are disclosed herein. The fluidic glasses includes at least one flexible fluidic lens having an outer housing and a flexible membrane supported within the outer housing, the flexible membrane at least partially defining a chamber that receives a fluid therein; and a fluid control system operatively coupled to the at least one flexible fluidic lens, the fluid control system configured to insert an amount of the fluid into the chamber of the at least one flexible fluidic lens, or remove an amount of the fluid from the chamber of the at least one flexible fluidic lens, in order to change the shape of the at least one flexible fluidic lens in accordance with the amount of fluid therein, thereby correcting the refractive errors of an eye of a human or animal.
    Type: Application
    Filed: February 9, 2021
    Publication date: June 3, 2021
    Inventor: Gholam A. Peyman
  • Patent number: 11020270
    Abstract: A vitrectomy instrument and a system including the same are disclosed herein. The vitrectomy instrument includes a handpiece having an outer tube and an inner tube coaxially disposed in the outer tube, the inner tube being slidably displaceable relative to the outer tube; a cutting power generator operatively coupled to the inner tube, the cutting power generator configured to reciprocably drive the inner tube for shearing tissue and/or vitreous; and an ultrasonic generator operatively coupled to the inner tube, the ultrasonic generator configured to vibrate the inner tube for vibratory fragmentation and/or cutting of the tissue and/or the vitreous. The vitrectomy system may include the vitrectomy instrument together with a support sleeve for supporting the vitrectomy instrument to provide increased rigidity to the needle of the vitrectomy instrument.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: June 1, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210113375
    Abstract: A method of lamellar corneal graft implantation is disclosed herein. The method includes the steps of: (i) forming one or more intrastromal incisions in a cornea of an eye of a patient; (ii) removing a cut portion of the cornea defined by the one or more intrastromal incisions from the eye of the patient; (iii) applying laser energy to a lamellar corneal graft using an excimer laser so as to modify the refractive power of the lamellar corneal graft, the lamellar corneal graft being in the form of a autologous corneal graft or a homologous corneal graft; and (iv) implanting the lamellar corneal graft into the eye of the patient in a location previously occupied by the cut portion of the cornea so as to correct the refractive power of the eye of the patient.
    Type: Application
    Filed: December 26, 2020
    Publication date: April 22, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210093884
    Abstract: A photodynamic therapy technique for preventing damage to the fovea of the eye or another body portion of a patient is disclosed herein. In one embodiment, a treatment laser is applied to a body portion of a patient using a painting technique, the treatment laser being configured to provide paint brush-type photodynamic therapy (PPDT) using the painting technique to the body portion of the patient by emitting light of a predetermined wavelength that is absorbed by tissue of the body portion of the patient to which a photosensitizer has been applied, the body portion of the patient being afflicted by a medical condition. The application of the treatment laser to the body portion of a patient using the painting technique treats the medical condition, reduces the symptoms associated with the medical condition, and/or alleviates the medical condition.
    Type: Application
    Filed: November 29, 2020
    Publication date: April 1, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210069016
    Abstract: A method of treatment is disclosed herein. The method includes administering to a patient in need thereof a biocompatible drug by at least one of intravenously, systemically, intravitreally, through the choroid, in the cerebrospinal fluid (CSF), topically, through the conjunctival mucosa, through the nasal mucosa, through the cornea, through the retinal optic nerve, through the nasal mucosa olfactory nerve, in the brain, in the spinal cord, the biocompatible drug comprising one or more cell pathway inhibitors together with one or more complement pathway inhibitors and/or one or more TGF beta inhibitors, the patient having one or more neurodegenerative disorders. The administration of the biocompatible drug to the patient treats the one or more neurodegenerative disorders, reduces the symptoms associated with the one or more neurodegenerative disorders, and/or alleviates the one or more neurodegenerative disorders.
    Type: Application
    Filed: November 23, 2020
    Publication date: March 11, 2021
    Inventor: Gholam A. Peyman
  • Patent number: 10925723
    Abstract: An apparatus (200, 200A, 200B, 200C) has central lens body (212, 212A, 212B, 212C) for providing vision correction for a patient. The lens body (212, 212A, 212B, 212C) has an initial index of refraction and is formed from at least one material configured to have a second index of refraction when subjected to a laser and/or radiation.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: February 23, 2021
    Inventors: Gholam Peyman, Lisa Brothers Arbisser
  • Patent number: 10925889
    Abstract: A method of treating, reducing, or alleviating a medical condition in a patient is disclosed herein. The method includes administering to a patient in need thereof a biocompatible drug comprising one or more antiviral medications together with one or more cell pathway inhibitors dissolved in a non-toxic semifluorinated alkane, the patient having one or more respiratory tract inflammatory diseases, the one or more cell pathway inhibitors blocking an inflammatory response of inflamed tissue without inhibiting an immune response of the patient, and the semifluorinated alkane evaporating quickly upon administration to the patient so as to leave the biocompatible drug at a desired treatment location. The administration of the biocompatible drug to the patient treats the one or more respiratory tract inflammatory diseases, reduces the symptoms associated with the one or more respiratory tract inflammatory diseases, and/or alleviates one or more respiratory tract inflammatory diseases.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: February 23, 2021
    Inventor: Gholam A. Peyman
  • Publication number: 20210002338
    Abstract: Cancer treatment methods using thermotherapy and/or enhanced immunotherapy are disclosed herein. One two-stage cancer treatment method comprises the steps of: (i) in a first stage, administering, to a patient with a metastatic malignancy, tumor-antibody-coated nanoparticles conjugated with one or more medications and/or one or more immune stimulators for attaching to circulating exosomes, extracellular vesicles, and/or circulating tumor cells, thus promoting a destruction of the circulating exosomes, extracellular vesicles, and/or circulating tumor cells by a cellular immune system of the patient; and (ii) in a second stage, treating a main tumor of the patient during the same session or during another session of therapy by administering the tumor-antibody-coated nanoparticles conjugated with the one or more medications and/or the one or more immune stimulators so as to stimulate the cellular immune response of the patient to destroy the main tumor.
    Type: Application
    Filed: August 9, 2020
    Publication date: January 7, 2021
    Inventor: Gholam A. Peyman
  • Patent number: 10881503
    Abstract: A method of corneal implantation with cross-linking is disclosed herein. In one or more embodiments, the method includes the steps of: (i) forming a flap in a cornea of an eye so as to expose a stromal tissue of the cornea underlying the flap; (ii) pivoting the flap so as to expose the stromal tissue of the cornea underlying the flap; (iii) inserting an implant under the flap so as to overlie the stromal tissue of the cornea; (iv) applying laser energy and/or microwaves to the implant in the eye so as to modify the refractive power of the implant; (v) applying a cross-linking solution that includes a photosensitizer to the implant; (vi) covering the implant with the flap; and (vii) irradiating the implant so as to activate cross-linkers in the implant, and thereby cross-link the implant and the stromal tissue of the cornea surrounding the implant.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: January 5, 2021
    Inventor: Gholam A. Peyman
  • Patent number: 10842669
    Abstract: A method of treatment is disclosed herein. The method includes administering to a patient in need thereof a polymer implant device containing a biocompatible drug, or a plurality of nanoparticles or microparticles conjugated with the biocompatible drug, the biocompatible drug comprising one or more Rock inhibitors, one or more Wnt inhibitors, one or more integrin inhibitors, and/or one or more glycogen synthase kinase 3 (GSK-3) inhibitors, the patient having a medical condition selected from the group consisting of dry eye, glaucoma, retinal detachment, retinal degeneration, age-related macular degeneration, a cataract, uveitis, a corneal genetic disease, postoperative inflammation, immune-related inflammatory processes, diabetic retinopathy, a side effect occurring after cataract surgery, a side effect occurring after refractive surgery, and combinations thereof.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 24, 2020
    Inventor: Gholam A. Peyman
  • Publication number: 20200345896
    Abstract: A method of corneal implantation with cross-linking is disclosed herein. In one or more embodiments, the method includes the steps of: (i) prior to implantation, treating an implant formed from donor corneal tissue or a tissue culture grown corneal stroma with a solution of sodium dodecyl sulfate (SDS), Triton X-100, benzalkonium chloride (BAK), Igepal, genipin, 100% glycerol, or alcohol for making the implant acellular, and for killing any bacteria, viruses, or parasites prior to implantation; (ii) implanting the implant into a recipient cornea; (iii) applying laser energy to the implant so as to modify the refractive power of the implant while being monitored using a Shack-Hartmann wavefront system so as to achieve a desired refractive power for the implant; and (iv) applying a cross-linking solution and irradiating the implant to cross-link the implant to prevent an immune response to the implant and/or rejection of the implant by a patient.
    Type: Application
    Filed: July 21, 2020
    Publication date: November 5, 2020
    Inventor: Gholam A. Peyman
  • Publication number: 20200337830
    Abstract: A method of forming and implanting a synthetic corneal lenslet in an eye of a patient includes the steps of: forming a synthetic lenslet from a collagen solution using a mold or a 3-D printer that are configured to form the synthetic lenslet into a predetermined shape for correcting a particular refractive error of the patient; forming a cavity for receiving the synthetic lenslet in the cornea of the eye of the patient; inserting the synthetic lenslet into the cavity of the eye; applying a photosensitizer into the cavity of the eye so that the photosensitizer permeates at least a portion of the tissue surrounding the cavity and at least a portion of the synthetic lenslet; and irradiating the cornea so as to activate cross-linkers in the synthetic lenslet and cross-linkers in the portion of the tissue surrounding the cavity, and thereby prevent an immune response.
    Type: Application
    Filed: July 13, 2020
    Publication date: October 29, 2020
    Inventor: Gholam A. Peyman
  • Publication number: 20200289534
    Abstract: A method of treating, reducing, or alleviating a medical condition in a patient is disclosed herein. The method includes administering to a patient in need thereof a biocompatible drug comprising one or more antiviral medications together with one or more cell pathway inhibitors dissolved in a non-toxic semifluorinated alkane, the patient having one or more respiratory tract inflammatory diseases, the one or more cell pathway inhibitors blocking an inflammatory response of inflamed tissue without inhibiting an immune response of the patient, and the semifluorinated alkane evaporating quickly upon administration to the patient so as to leave the biocompatible drug at a desired treatment location. The administration of the biocompatible drug to the patient treats the one or more respiratory tract inflammatory diseases, reduces the symptoms associated with the one or more respiratory tract inflammatory diseases, and/or alleviates one or more respiratory tract inflammatory diseases.
    Type: Application
    Filed: April 28, 2020
    Publication date: September 17, 2020
    Inventor: Gholam A. Peyman
  • Patent number: 10736571
    Abstract: A glaucoma testing device and a method of using the same are disclosed herein. The glaucoma testing device includes a device body portion having an outer housing and a flexible membrane at least partially defining a chamber supported within the outer housing; a fluid control system configured to insert an amount of the fluid into the chamber of the device body portion in order to expand the flexible membrane and exert pressure on an eye of a patient, or remove an amount of the fluid from the chamber of the device body portion in order to deflate the membrane and relieve pressure exerted on the eye; and a laser fiber optic configured to transmit a beam of light into the eye so as to produce a detectable ultrasonic wave so that an oxygenation level of the eye of the patient is capable of being determined using a photoacoustic system.
    Type: Grant
    Filed: October 14, 2017
    Date of Patent: August 11, 2020
    Inventor: Gholam A. Peyman
  • Publication number: 20200246179
    Abstract: A method of therapy for a tumor or other pathology by administering thermotherapy or a combination of thermotherapy and immunotherapy optionally combined with gene delivery. The combination therapy beneficially treats the tumor and prevents tumor recurrence, either locally or at a different site, by boosting the patient's immune response both at the time of original therapy and/or for later therapy. The therapy may further include the administration of a vaccine.
    Type: Application
    Filed: April 8, 2020
    Publication date: August 6, 2020
    Inventor: Gholam A. Peyman