Patents by Inventor Gholamreza Javahery

Gholamreza Javahery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250014883
    Abstract: A deposit-reducing ionization source for sample introduction to a mass spectrometer is provided. It comprises a heated vessel with a set of circulating hot gases to avoid any condensation to be formed within the volume of the vessel, keeping the vessel clean. The vessel has a tubular cross section with a conduit attached to its side wall. The vessel is placed in front of the orifice of a curtain cone. An exhaust port is on the opposite side of the conduit on the wall and close to the curtain cone. A nebulizer is placed inside the conduit. A nebulizing gas and an auxiliary gas are introduced in the conduit and a curtain gas is introduced in the curtain cone.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 9, 2025
    Inventors: Gholamreza Javahery, Ramin Sharifi, Victor Titov, Dmitry Valyaev, Fadi Jozif
  • Publication number: 20240258093
    Abstract: The present system is a filament and an ion guide configuration. The ion source and an ion guide are combined in one system to create a fast release of ions, with increased efficiency of ion transport. The present device is a high-efficiency ion source operating at very low up to a few Torr pressure. Ions generated from the source immediately introduced into or created in an ion guide. The ions are introduced in or around the zero field lines of the RF field. Therefore, they will be trapped under the influence of the RF field there and can be transported to the next region of the mass spectrometer device. One method of transferring ions is by using ion-guides. Multipole ion guides have efficiently transferred ions through a vacuum or partial vacuum into mass analyzers. In particular, multipole ion guides have been configured to transport ions from a higher pressure region of a mass spectrometer to the lower pressure and then vacuum where the analyzer is operational.
    Type: Application
    Filed: July 11, 2022
    Publication date: August 1, 2024
    Inventors: Gholamreza Javahery, Fadi Jozif, Babak Shahabi, Farshid Pashaee
  • Publication number: 20240162024
    Abstract: A combined ion discharge tube and an ion guide system is disclosed. The ion discharge tube comprises of a cathode tube and an anode surface. The discharge tube acts as the cathode, whereas the anode can be any number of different configurations. In one embodiment the discharge tube is set inside a quadrupole ion guide, with the walls of the ion guide being the anode. In other embodiments, the discharge tube is placed inside the rods of the quadrupole and the inner walls of the rods or a separate plate acting as the anode. In all configurations, the ions are formed by the discharge tube and are introduced into the RF confinement of an ion guide to increase ion transfer efficiency.
    Type: Application
    Filed: March 14, 2022
    Publication date: May 16, 2024
    Inventors: Gholamreza Javahery, Victor Titov, Dmitry Valyaev, Fadi Jozif
  • Patent number: 11864303
    Abstract: An air cooled inductively coupled plasma mass spectrometer (ICP-MS) is disclosed. The interface structure has a configuration that it can rapidly transfer heat away from the front surface of the interface that is exposed to a high temperature plasma, while maintaining heat in the ion beam to avoid recombination and clustering. The air cooled interface of the present system comprises of a set of fins for rapid heat transfer, which may be placed along the sides of the ICP-MS systems in a variety of orientations. Open-cell metal foam is also used to increase heat transfer efficiency. The system may be cooled by natural convention or forced convection using one or more air fans.
    Type: Grant
    Filed: November 17, 2021
    Date of Patent: January 2, 2024
    Inventors: Sina Alavi, Gholamreza Javahery, Javad Mostaghimi, Kaveh Kahen
  • Patent number: 11705319
    Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.
    Type: Grant
    Filed: June 6, 2021
    Date of Patent: July 18, 2023
    Assignee: PerkinElmer Scientific Canada ULC
    Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
  • Patent number: 11631578
    Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: April 18, 2023
    Assignee: PerkinElmer U.S. LLC
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 11621153
    Abstract: A system for sampling and analysis of the chemical composition of any material from any surface is provided. The system comprises of a sniffing line to collect a specimen from a surface for evaluation and a thermal desorption system to thermally desorb an analyte from the sampled material, The system may further comprise of an ionization system to form an ionized analyte. A mass spectrometer is then used to analyze the chemical composition of the ionized analyte sample.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: April 4, 2023
    Inventors: Gholamreza Javahery, Ali Sepehri Fard
  • Patent number: 11594407
    Abstract: A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: February 28, 2023
    Inventors: Gholamreza Javahery, Ali Sepehri Fard
  • Publication number: 20220223399
    Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.
    Type: Application
    Filed: August 16, 2021
    Publication date: July 14, 2022
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 11367603
    Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: June 21, 2022
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Publication number: 20220102130
    Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.
    Type: Application
    Filed: June 6, 2021
    Publication date: March 31, 2022
    Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
  • Publication number: 20220084805
    Abstract: A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.
    Type: Application
    Filed: September 14, 2021
    Publication date: March 17, 2022
    Inventors: Gholamreza Javahery, Ali Sepehri Fard
  • Publication number: 20210391163
    Abstract: A system for sampling and analysis of the chemical composition of any material from any surface is provided. The system comprises of a sniffing line to collect a specimen from a surface for evaluation and a thermal desorption system to thermally desorb an analyte from the sampled material, The system may further comprise of an ionization system to form an ionized analyte. A mass spectrometer is then used to analyze the chemical composition of the ionized analyte sample.
    Type: Application
    Filed: June 7, 2021
    Publication date: December 16, 2021
    Inventors: Gholamreza Javahery, Ali Sepehri Fard
  • Patent number: 11094520
    Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: August 17, 2021
    Assignee: PERKINELMER HEALTH SCIENCES CANADA, INC.
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 11031227
    Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: June 8, 2021
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
  • Publication number: 20200395205
    Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.
    Type: Application
    Filed: May 18, 2020
    Publication date: December 17, 2020
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Publication number: 20200350150
    Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.
    Type: Application
    Filed: May 7, 2020
    Publication date: November 5, 2020
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 10658167
    Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.
    Type: Grant
    Filed: September 29, 2018
    Date of Patent: May 19, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 10658168
    Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: May 19, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 10636645
    Abstract: A mass analyzer includes two chambers for ionizing gas to form ions and/or introducing reaction gases to aid in ionization. A first chamber includes an electron to allow electron bombardment of a first gas. A second chamber receives a second gas and ions from the first chamber to allow interaction between the second gas, and the ions from the first chamber. The first and/or second gas may include analyte.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 28, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe, Miles Snow