Patents by Inventor Gholamreza Javahery
Gholamreza Javahery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11631578Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: GrantFiled: August 16, 2021Date of Patent: April 18, 2023Assignee: PerkinElmer U.S. LLCInventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 11621153Abstract: A system for sampling and analysis of the chemical composition of any material from any surface is provided. The system comprises of a sniffing line to collect a specimen from a surface for evaluation and a thermal desorption system to thermally desorb an analyte from the sampled material, The system may further comprise of an ionization system to form an ionized analyte. A mass spectrometer is then used to analyze the chemical composition of the ionized analyte sample.Type: GrantFiled: June 7, 2021Date of Patent: April 4, 2023Inventors: Gholamreza Javahery, Ali Sepehri Fard
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Patent number: 11594407Abstract: A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.Type: GrantFiled: September 14, 2021Date of Patent: February 28, 2023Inventors: Gholamreza Javahery, Ali Sepehri Fard
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Publication number: 20220223399Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: ApplicationFiled: August 16, 2021Publication date: July 14, 2022Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 11367603Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.Type: GrantFiled: May 7, 2020Date of Patent: June 21, 2022Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Publication number: 20220159819Abstract: An air cooled inductively coupled plasma mass spectrometer (ICP-MS) is disclosed. The interface structure has a configuration that it can rapidly transfer heat away from the front surface of the interface that is exposed to a high temperature plasma, while maintaining heat in the ion beam to avoid recombination and clustering. The air cooled interface of the present system comprises of a set of fins for rapid heat transfer, which may be placed along the sides of the ICP-MS systems in a variety of orientations. Open-cell metal foam is also used to increase heat transfer efficiency. The system may be cooled by natural convention or forced convection using one or more air fans.Type: ApplicationFiled: November 17, 2021Publication date: May 19, 2022Inventors: Sina ALAVI, Gholamreza JAVAHERY, Javad MOSTAGHIMI, Kaveh KAHEN
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Publication number: 20220102130Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.Type: ApplicationFiled: June 6, 2021Publication date: March 31, 2022Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
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Publication number: 20220084805Abstract: A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.Type: ApplicationFiled: September 14, 2021Publication date: March 17, 2022Inventors: Gholamreza Javahery, Ali Sepehri Fard
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Publication number: 20210391163Abstract: A system for sampling and analysis of the chemical composition of any material from any surface is provided. The system comprises of a sniffing line to collect a specimen from a surface for evaluation and a thermal desorption system to thermally desorb an analyte from the sampled material, The system may further comprise of an ionization system to form an ionized analyte. A mass spectrometer is then used to analyze the chemical composition of the ionized analyte sample.Type: ApplicationFiled: June 7, 2021Publication date: December 16, 2021Inventors: Gholamreza Javahery, Ali Sepehri Fard
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Patent number: 11094520Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: GrantFiled: May 18, 2020Date of Patent: August 17, 2021Assignee: PERKINELMER HEALTH SCIENCES CANADA, INC.Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 11031227Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.Type: GrantFiled: May 10, 2019Date of Patent: June 8, 2021Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
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Publication number: 20200395205Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: ApplicationFiled: May 18, 2020Publication date: December 17, 2020Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Publication number: 20200350150Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.Type: ApplicationFiled: May 7, 2020Publication date: November 5, 2020Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 10658167Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.Type: GrantFiled: September 29, 2018Date of Patent: May 19, 2020Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 10658168Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: GrantFiled: May 3, 2018Date of Patent: May 19, 2020Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 10636645Abstract: A mass analyzer includes two chambers for ionizing gas to form ions and/or introducing reaction gases to aid in ionization. A first chamber includes an electron to allow electron bombardment of a first gas. A second chamber receives a second gas and ions from the first chamber to allow interaction between the second gas, and the ions from the first chamber. The first and/or second gas may include analyte.Type: GrantFiled: April 20, 2018Date of Patent: April 28, 2020Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe, Miles Snow
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Patent number: 10622200Abstract: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.Type: GrantFiled: May 18, 2018Date of Patent: April 14, 2020Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Anna Kornilova, Gholamreza Javahery, Lisa Cousins
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Publication number: 20190355566Abstract: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.Type: ApplicationFiled: May 18, 2018Publication date: November 21, 2019Inventors: Anna Kornilova, Gholamreza Javahery, Lisa Cousins
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Publication number: 20190355565Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.Type: ApplicationFiled: May 10, 2019Publication date: November 21, 2019Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
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Publication number: 20190341241Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: ApplicationFiled: May 3, 2018Publication date: November 7, 2019Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe