Patents by Inventor Gi-Eun Choi

Gi-Eun Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticle type oligonucleotide structure having high efficiency and method for preparing same
    Patent number: 10030243
    Abstract: The present invention relates to an oligonucleotide structure and a method for preparing the same and, more particularly, to an oligonucleotide structure in which a polymer compound is linked to an oligonucleotide via a covalent bond to improve in vivo stability of the oligonucleotide and cellular delivery efficiency of the oligonucleotide; and to a method for preparing the same.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: July 24, 2018
    Assignee: BIONEER CORPORATION
    Inventors: Han Oh Park, Jeiwook Chae, Pyoung Oh Yoon, Boram Han, Gi-Eun Choi, Youngho Ko, Taewoo Kwon, Jae Don Lee, Sun Gi Kim
  • IMPROVED NANOPARTICLE TYPE OLIGONUCLEOTIDE STRUCTURE HAVING HIGH EFFICIENCY AND METHOD FOR PREPARING SAME
    Publication number: 20170152512
    Abstract: The present invention relates to an oligonucleotide structure and a method for preparing the same and, more particularly, to an oligonucleotide structure in which a polymer compound is linked to an oligonucleotide via a covalent bond to improve in vivo stability of the oligonucleotide and cellular delivery efficiency of the oligonucleotide; and to a method for preparing the same.
    Type: Application
    Filed: July 4, 2014
    Publication date: June 1, 2017
    Inventors: Han Oh Park, Jeiwook Chae, Pyoung Oh Yoon, Boram Han, Gi-Eun Choi, Youngho Ko, Taewoo Kwon, Jae Don Lee, Sun Gi Kim
  • LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME
    Publication number: 20160168573
    Abstract: There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 16, 2016
    Inventors: Jeiwook Chae, Han Oh Park, Pyoung Oh Yoon, Boram Han, Han-na Kim, Sung-II Yun, Jun Hong Park, Youngho Ko, Gi-Eun Choi, Junsoo Jung, Jae Eun Kim
  • LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME
    Publication number: 20160145624
    Abstract: There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly ZBTB7A, YAP1 or CHD1L specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
    Type: Application
    Filed: July 9, 2014
    Publication date: May 26, 2016
    Inventors: Jeiwook Chae, Pyoung Oh Yoon, Han-na Kim, Han Oh Park, Boram Han, Youngho Ko, Gi-Eun Choi, Jae Eun Kim