Patents by Inventor Gian Cesare Tron

Gian Cesare Tron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRPM8 receptor agonist compounds and uses thereof
    Patent number: 10905679
    Abstract: The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: February 2, 2021
    Assignee: UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
    Inventors: Antonio Vicente Ferrer Montiel, Asia Fernandez Carvajal, Carlos Belmonte Martinez, Juana Gallar Martinez, Roberto De La Torre, Armando Genazzani, Gian Cesare Tron, Valentina Mercalli
  • TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF
    Publication number: 20190022068
    Abstract: The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(O)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(O)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted; g) CH(OH)—(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)—(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.
    Type: Application
    Filed: January 17, 2017
    Publication date: January 24, 2019
    Applicant: Universidad Miguel Hernandez De Elche
    Inventors: Antonio Vicente FERRER MONTIEL, Asia FERNANDEZ CARVAJAL, Carlos BELMONTE MARTINEZ, Juana GALLAR MARTINEZ, Roberto DE LA TORRE, Armando GENAZZANI, Gian Cesare TRON, Valentina MERCALLI
  • INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, COMPOSITIONS, PRODUCTS AND USES THEREOF
    Publication number: 20160075682
    Abstract: Compounds of formula (I): able to inhibit nicotinamide phosphoribosyltransferase. The disclosure also relates to the use of compounds of formula (I) for treatment of pathological conditions in which NAMPT inhibition might be beneficial, such as acute and chronic inflammation, cancer and metabolic disorders.
    Type: Application
    Filed: April 29, 2014
    Publication date: March 17, 2016
    Applicant: UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO"
    Inventors: Armando A. GENAZZANI, Gian Cesare TRON, Ubaldina GALLI, Cristina TRAVELLI, Salvatore CUZZOCREA, Giorgio GROSA, Giovanni SORBA, Pier Luigi CANONICO
  • Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
    Patent number: 8841288
    Abstract: Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 23, 2014
    Assignees: Universtà Degli Studi di Torino, Università Degli Studi del Piemonte Orientale “Amedeo Avogadro”
    Inventors: Giovanni Sorba, Gian Cesare Tron, Ubaldina Galli, Alberto Massarotti, Emilio Hirsch, Elisa Ciraolo, Tracey Pirali
  • QUINOLIN-4 (1H) -ONE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASES
    Publication number: 20130245005
    Abstract: Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity.
    Type: Application
    Filed: November 28, 2011
    Publication date: September 19, 2013
    Applicants: UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO", UNIVERSITA DEGLI STUDI DI TORINO
    Inventors: Giovanni Sorba, Gian Cesare Tron, Ubaldina Galli, Alberto Massarotti, Emilio Hirsch, Elisa Ciraolo, Tracey Pirali