Patents by Inventor Gian Luca Araldi

Gian Luca Araldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180243260
    Abstract: Disclosed herein are methods of treating cognitive and behavioral impairment in Down syndrome and/or Alzheimer's disease patients, Alzheimer's disease, neurodegenerative disease, cancer, DYRK1A-mediated disorders and methods of modulating and inhibiting DYRK1-A comprising use of catechins.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 30, 2018
    Inventor: Gian Luca ARALDI
  • Publication number: 20180000774
    Abstract: The present invention relates to methods of treating cognitive and behavioral impairment in Down syndrome and/or Alzheimer's disease patients, Alzheimer's disease, neurodegenerative disease, cancer, DYRK1A-mediated disorders and methods of modulating and inhibiting DYRK1-A comprising use of catechins.
    Type: Application
    Filed: June 27, 2017
    Publication date: January 4, 2018
    Applicant: AVANTI BIOSCIENCES, INC
    Inventor: GIAN LUCA ARALDI
  • Patent number: 8349836
    Abstract: The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: January 8, 2013
    Inventors: Gian-Luca Araldi, Matthew Ronsheim, Melanie Ronsheim
  • Patent number: 8058305
    Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: November 15, 2011
    Assignee: Merck Serono SA
    Inventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
  • Patent number: 8044103
    Abstract: The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: October 25, 2011
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Alan I. Faden, Gian Luca Araldi
  • Patent number: 8044041
    Abstract: The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives of formula (III) that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: October 25, 2011
    Assignee: Forest Laboratories Holdings Limited
    Inventors: Gian-Luca Araldi, Matthew Ronsheim, Melanie Ronsheim
  • Publication number: 20110237571
    Abstract: The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 29, 2011
    Inventors: Gian-Luca Araldi, Matthew Ronsheim, Melanie Ronsheim
  • Patent number: 7897595
    Abstract: The present invention relates to pyridoazepine derivatives that act as 5-HT ligands, e.g., 5-HT2 C. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: March 1, 2011
    Assignee: Forest Laboratories Holdings Limited
    Inventors: Gian-Luca Araldi, Alexander Bischoff, Nhut K. Diep
  • Patent number: 7863312
    Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: January 4, 2011
    Assignee: Merck Serono SA
    Inventors: Gian Luca Araldi, Yihua Liao, Adulla P. Reddy, Zhong Zhao
  • Patent number: 7696243
    Abstract: The present invention is directed to compounds that may be used as agonists of prostaglandin receptors. More specifically, the specification describes methods and compositions for making and using DP1 receptor agonists that are pyrrolidin-2-one derivatives.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: April 13, 2010
    Assignee: Merck Serono, S.A.
    Inventor: Gian Luca Araldi
  • Patent number: 7635713
    Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: December 22, 2009
    Assignee: Laboratoires Serono SA
    Inventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
  • Publication number: 20090292000
    Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.
    Type: Application
    Filed: August 3, 2009
    Publication date: November 26, 2009
    Applicant: LABORATOIRES SERONO S.A.
    Inventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
  • Publication number: 20090192315
    Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 24, 2008
    Publication date: July 30, 2009
    Applicant: FOREST LABORATORIES HOLDINGS LIMITED
    Inventors: Gian-Luca Araldi, Melanie Ronsheim, Nhut Diep, Shao Hong Zhou
  • Patent number: 7563797
    Abstract: The present invention relates to compounds of formula I, II, III or IV: wherein R1-R4, R7-R10, R13-R17 and R20-R24 are as described herein. The compounds are active as cannabinoid receptor ligands, e.g., CB2 ligands. Methods of preparing the compounds, compositions containing the compounds and methods of treatment using the compounds are also disclosed.
    Type: Grant
    Filed: August 27, 2007
    Date of Patent: July 21, 2009
    Assignee: Forest Laboratories Holding Limited
    Inventors: Gian-Luca Araldi, Matthew Ronsheim, Nhut K. Diep
  • Publication number: 20090143593
    Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 12, 2009
    Publication date: June 4, 2009
    Applicant: FOREST LABORATORIES HOLDINGS LIMITED
    Inventors: Gian-Luca Araldi, Melanie Ronsheim, Nhut Diep, Shao Hong Zhou
  • Patent number: 7511150
    Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: March 31, 2009
    Assignee: Forest Laboratories Holdings Limited
    Inventors: Gian-Luca Araldi, Melanie Ronsheim, Nhut Diep, Shao Hong Zhou
  • Patent number: 7501438
    Abstract: The present invention relates to pyridoimidazole derivatives that act as cannabinoid receptor ligands, e.g., CB2 ligands. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: March 10, 2009
    Assignee: Forest Laboratories Holdings Limited
    Inventors: Matthew Ronsheim, Gian-Luca Araldi
  • Patent number: 7465755
    Abstract: The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: December 16, 2008
    Assignee: Laboratoires Serono SA
    Inventors: Gian Luca Araldi, Yihua Liao, Nadia Brugger
  • Publication number: 20080234346
    Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.
    Type: Application
    Filed: May 14, 2008
    Publication date: September 25, 2008
    Applicant: LABORATOIRES SERONO S.A.
    Inventors: Gian Luca ARALDI, Yihua Liao, Adulla P. Reddy, Zhong Zhao
  • Patent number: 7419999
    Abstract: 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: September 2, 2008
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Gian Luca Araldi, Adulla P. Reddy, Zhong Zhao, Sean D. McKenna, Bagna Bao